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American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2022 American Transplant Congress

    Diabetes is a Significant and Independent Predictor for Tacrolimus Immediate Release (IR) and LCP-Tacrolimus (LCP) Conversion Ratios

    K. S. Coffman, N. Patel, F. Bartlett, J. Newman, S. Patel, T. Sprague, N. Rao, E. Andrade, M. Casey, V. Rohan, D. DuBay, D. Taber

    Medical University of South Carolina, Charleston, SC

    *Purpose: Diabetes (DM) is a common comorbidity seen in transplant patients with known effects on GI motility and absorption; however, DMs impact on the IR…
  • 2022 American Transplant Congress

    Induction Immunosuppression in ABO-Incompatible Liver Transplant Recipients

    S. Shaikh1, I. Hasan1, N. Kaur2

    1Keck Medicine of USC, Los Angeles, CA, 2Keck School of Medicine, Los Angeles, CA

    *Purpose: ABO-incompatible (ABO-i) liver transplantation (LT) has been associated with an increased risk of AMR, as well as poor patient and graft survival. With advances…
  • 2022 American Transplant Congress

    Impact Of Nirmatrelvir-Ritonavir On Tacrolimus Concentrations

    S. Fredrick1, B. Wise2, L. Bowman2, D. DeWolfe1, J. Taylor1, J. Melaragno1

    1University of Rochester Medical Center, Rochester, NY, 2Tampa General Hospital, Tampa, FL

    *Purpose: Ritonavir (RTV), a component of the oral antiviral agent nirmatrelvir-RTV (Paxlovid) for COVID-19 infection, increases tacrolimus concentrations through strong competitive inhibition of gastrointestinal and…
  • 2022 American Transplant Congress

    Effect of Mycophenolate Mofetil Dosing on Antibody Response to SARS-CoV-2 Vaccination in Heart and Lung Transplant Recipients

    J. Mitchell1, T. P. Chiang1, J. Alejo1, A. Chang1, A. Abedon1, R. Avery1, A. Tobian1, A. Massie1, M. Levan1, D. Warren1, J. Garonzik-Wang2, D. Segev1, W. Werbel1

    1Johns Hopkins University, Baltimore, MD, 2University of Wisconsin-Madison, Madison, WI

    *Purpose: Mycophenolate mofetil (MMF) use is associated with decreased antibody response to the SARS-CoV-2 mRNA vaccine series in heart and lung transplant recipients (HLTRs). Higher…
  • 2022 American Transplant Congress

    Intensive Antimetabolite Reduction is Not Associated with Increased Risk of Biopsy-Proven Acute Rejection in Kidney Transplant Recipients with BK Virus Infection; a Single Center Experience

    J. Marvin1, D. Malhotra2, P. Jethwani2, K. Belfield1, E. Cohen1

    1Yale New Haven Hospital, New Haven, CT, 2Section of Nephrology, Yale School of Medicine, New Haven, CT

    *Purpose: Polyoma BK virus (BKV) is a ubiquitous DNA virus that is capable of reactivation and infection in kidney transplant recipients (KTR). Manifestations of the…
  • 2022 American Transplant Congress

    Impact of Changing Tacrolimus Formulation on Cerebral Blood Flow and Cognitive Function

    I. Mahaparn, R. Lepping, R. N. Montgomery, R. Mukherjee, S. Billinger, W. M. Brooks, A. Gupta

    University of Kansas Medical Center (KUMC), Kansas City, KS

    *Purpose: To assess if switching to extended release (ER) tacrolimus changes cerebral blood flow (CBF) or cognitive function after switching stable kidney transplant (KT) recipients…
  • 2022 American Transplant Congress

    Conversion to Belatacept for Calcineurin Inhibitor Toxicities

    S. S. Patel, P. Jadav, M. Sekulic, S. Kudose, I. Batal, S. Mohan, R. Crew

    Columbia University Medical Center, New York, NY

    *Purpose: Calcineurin inhibitors (CNIs) have improved renal transplant (RTx) outcomes but are associated with significant toxicities. Belatacept provides better long-term outcomes than cyclosporine, has less…
  • 2022 American Transplant Congress

    High TTV Load Before First Vaccine Dose is Associated with Poor Serological Response to Covid-19 Vaccination in Lung Transplant Recipients

    C. C. Van Leer Buter1, R. A. Hoek2, E. A. Verschuuren3, R. D. de Vries4, D. van Baarle1, M. van der Heiden1, H. G. Niesters1, C. GeurtsvanKessel4

    1Dept. of Medical Microbiology, University Medical Center Groningen, Groningen, Netherlands, 2Dept. of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands, 3Dept. of Pulmonary Diseases,, University Medical Center Groningen, Groningen, Netherlands, 4Dept. of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: Torque tenovirus (TTV), a highly prevalent virus which is not known to cause pathology in humans, is currently being investigated as a marker of…
  • 2022 American Transplant Congress

    The Role of Gut Microbiota in Tacrolimus Blood Level Fluctuation, Time in Therapeutic Range and AlloSure Donor Derived Cell-Free DNA, Controlling for CYP3A5

    M. Nayebpour1, N. Koizumi1, J. Melancon2, M. Hasan2

    1George Mason University, Arlington, VA, 2George Washington University Hospital, Washington, DC

    *Purpose: High tacrolimus variability (TV), low time in therapeutic range (TTR) and high percentage of donor derived cell-free DNA (dd-cfDNA) are associated with acute kidney…
  • 2022 American Transplant Congress

    An Immune-Modulatory Strategy to Mitigate Hepatic Ischemia Reperfusion Injury in a Murine Model

    S. Duarte, A. Kobayashi, V. Boominathan, A. Kwiatkowski, J. Simonovich, A. Wanchoo, G. Hudalla, B. Keselowsky, A. Zarrinpar

    University of Florida, Gainesville, FL

    *Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…
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