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Articles tagged "Immunosuppression"

  • 2022 American Transplant Congress

    The Impact of Maintenance Immunosuppressive Regimen on COVID-19 Outcomes Among Kidney Transplant Patients

    T. V. Sandes-Freitas1, L. Modelli de Andrade2, L. Requião-Moura3, J. Medina-Pestana3, H. Tedesco-Silva3, A. on behalf of Covid-19 KT Brazil Study Group1

    1Universidade Federal do Ceará / Unidade Pesquisa Clínica CH-UFC/EBSERH, Fortaleza, Brazil, 2Universidade Estadual Paulista - UNESP, Botucatu, Brazil, 3Universidade Federal de São Paulo / Hospital do Rim, São Paulo, Brazil

    *Purpose: Compared to azathioprine (AZA), mycophenolate (MPA) is implicated in an increased risk of several viral infections. Contrariwise, mTOR inhibitors (mTORi) are protective. Therefore, the…
  • 2022 American Transplant Congress

    Risk of Post-Transplant Lymphoproliferative Disease After Anti-Thymocyte Globulin in Childhood Solid-Organ Transplant Recipients

    A. M. McKay1, C. Teoh1, J. Vasilevska-Ristovka2, J. Browne2, T. Banh2, A. Dipchand1, V. Ng1, M. Solomon1, U. Allen1, Y. Avitzur1, R. Parekh3

    1Transplant & Regenerative Medicine Centre, The Hospital for Sick Children, Toronto, ON, Canada, 2Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, 3Division of Nephrology, Department of Medicine, Women’s College Hospital and University Health Network, Toronto, ON, Canada

    *Purpose: Determine if the use of anti-thymocyte globulin (ATG) in pediatric solid organ transplant recipients was associated with an increased risk of post-transplant lymphoproliferative disorder…
  • 2022 American Transplant Congress

    Long-Term Insulin Independence Achieved by a Multimodal Approach to Beta-Cell Replacement in Patients with Type I Diabetes

    M. Nunez1, S. Wisel2, J. Gardner3, G. Worner4, G. Roll5, S. Syed3, G. Szot1, M. Tavakol1, K. Johnson1, A. Posselt4, P. Stock6

    1Surgery, University of California, San Francisco, San Francisco, CA, 2Cedars-Sinai Medical Center, Los Angeles, CA, 3University of California, San Francisco, San Francisco, CA, 4University of California San Francisco, San Francisco, CA, 5UCSF Medical Center, San Francisco, CA, 6Univ of California-San Francisco, San Francisco, CA

    *Purpose: Long-term insulin independence in beta-cell replacement, via islet or pancreas transplant, remains limited by the toxic effects of calcineurin inhibitors (CNI) on beta cells…
  • 2022 American Transplant Congress

    Incidence of Opportunistic Infections in Elderly Kidney Transplant Recipients on Belatacept

    K. Khalil, S. Jonchhe, J. Stern, R. Robalino, Z. A. Stewart, S. A. Mehta, N. Ali, H. Neumann

    Transplant Institute, NYU Langone Health, New York, NY

    *Purpose: The purpose of this study was to assess the incidence of opportunistic infections in elderly kidney transplant recipients (KTRs) who receive belatacept (BELA) for…
  • 2022 American Transplant Congress

    Renal Function at Five Years from a Randomized Multicenter Trial of Belatacept-Based CNI Free and Early Steroid Withdrawal Immunosuppression

    E. Yanqui1, H. Hames1, A. R. Shields1, T. Shi1, A. L. Christianson1, J. Kremer2, A. Govil1, R. R. Alloway1, E. S. Woodle1

    1University of Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH

    *Purpose: BENEFIT and BENEFIT EXT trials have demonstrated that belatacept-based immunosuppression was associated with improved long term renal allograft function compared to cyclosporine-based immunosuppression. Similar…
  • 2022 American Transplant Congress

    Immunosuppressants Alter Lymph Node Architecture and Create Distinct Microbiome Footprints

    S. J. Gavzy1, R. Lakhan2, J. Iyyathurai2, V. Saxena2, L. Li2, B. Ma2, E. Mongodin2, J. S. Bromberg2

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD

    *Purpose: There are complex interactions among immunosuppressants, antibiotics, and the gut microbiome on the host immune system. Microbiota can alter lymph node (LN) structure and…
  • 2022 American Transplant Congress

    Adenosine A2A Receptor (A2AR) Agonist Apadenoson Promotes Survival in K28-hACE2 Mice and Syrian Hamsters Infected with Sars-CoV-2

    P. Chhabra1, B. Mann2, M. Ma1, S. Feldman3, J. Linden4, K. L. Brayman1

    1Department of Surgery, University of Virginia Health System, Charlottesville, VA, 2Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA, 3Center for Comparative Medicine, University of Virginia Health System, Charlottesville, VA, 4Department of Nephrology, University of Virginia Health System, Charlottesville, VA

    *Purpose: To determine if Apadenoson or Regadenoson has a therapeutic effect in attenuating hyper-inflammation and improving survival rate in K18-hACE2mice or Syrian hamsters infected with…
  • 2022 American Transplant Congress

    Reduced Enterohepatic Recirculation of Mycophenolate and Lower Blood Concentrations Are Associated with the Stool Bacterial Microbiome

    P. A. Jacobson1, A. Saqr1, B. Carlson1, C. Staley2, A. Rashidi3, S. Holtan3, M. Al-Kofahi1, T. Kaiser2, M. MacMillan4, J. Young5, N. El Jurdi3, D. Weisdorf3, A. Khoruts6

    1Univ of MN, College of Pharmacy, Minneapolis, MN, 2Univ of MN, Dept of Surgery, Minneapolis, MN, 3Univ of MN, Divison of Heme/Onc Transplant, Minneapolis, MN, 4Univ of MN, Pediatric Heme/Onc Transplant, Minneapolis, MN, 5Univ of MN, Divison of Infectious Diseases, Minneapolis, MN, 6Univ of MN, Division of Gastroenterology, Hepatology and Nutrition, Minneapolis, MN

    *Purpose: Mycophenolate mofetil (MMF) is an important immunosuppressant used after allogeneic hematopoietic cell transplant (HCT). Blood concentrations of mycophenolic acid (MPA) are highly variable and…
  • 2022 American Transplant Congress

    Comparative Case Study of Mycobacterium Infections in Pediatric Post Intestinal Transplant

    S. Yerina1, R. Kanthula1, Y. Rekhtman2, S. Kaufman1, U. Ekong1, N. Yazigi1, T. Fishbein1, A. Kroemer1, C. Matsumoto1, K. Khan1

    1Transplant, Georgetown University Hospital, Washington, DC, 2GI and Nutrition, Prisma Health Midlands Children's Hospital, Columbia, SC

    *Purpose: We describe two rare and challenging post pediatric intestinal transplant cases with both Mycobacterium (M) Abscessus and Mycobacterium (M) Immunogenum in post surgical site…
  • 2022 American Transplant Congress

    Optimizing Kidney Transplant Immunosuppression Using a Phenotypic Personalized Dosing Model

    J. F. Bruner1, N. Padmanabhan2, C. Ho2, A. Zarrinpar1

    1Surgery, University of Florida, Gainesville, FL, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA

    *Purpose: Immunosuppression is essential for preventing rejection and promoting long-term graft survival following solid organ transplantation; it also places patients at risk for infection and…
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