2021 American Transplant Congress
Deceased Donor Transplantation Across Positive Flow Crossmatch – A Single Center Experience
University of Illinois at Chicago, Chicago, IL
*Purpose: Transplantation across a positive flow crossmatch (+FXM) has been established as a lifesaving measure in the living donor setting. Time required for desensitization limits…2021 American Transplant Congress
Leukopenia in the Renal Transplant Population
1Emory University, Atlanta, GA, 2Surgery, Emory University, Atlanta, GA
*Purpose: Leukopenia is a common complication for transplant patients on immunosuppression, but etiologies, timing, and outcomes are only superficially understood.*Methods: All patients undergoing kidney transplant…2021 American Transplant Congress
Belatacept-Resistant T Cells are Activated by IFNα-IRF7 Pathway
*Purpose: Second signal of activation play an important role in activation of T lymphocytes. Their control by checkpoint inhibitor is efficient in auto-immune disease and…2021 American Transplant Congress
Immunosuppression and Cancer Risk in Kidney Transplant Recipients: A Retrospective Cohort Study
1McGill University, Montreal, QC, Canada, 2McGill University Health Centre, Montreal, QC, Canada
*Purpose: Kidney transplant recipients (KTR) have an elevated risk of cancer. We sought to estimate to what extent does the immunosuppression regimen increase KTRs’ susceptibility…2021 American Transplant Congress
The Metagenomic Landscape of Renal Transplant
1Emory University, Atlanta, GA, 2Surgery, Emory University, Atlanta, GA
*Purpose: The selective targeting of T cells in transplant immunosuppression medications leads to a high rate of viral infections. Different immunosuppression regimens have been shown…2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…2021 American Transplant Congress
COVID-19 Transmission within One Year from Pancreas and Kidney Recipients
University of Minnesota, Minneapolis, MN
*Purpose: The current pandemic has created uncertainty surrounding the transmission of COVID-19. It was recently published that in the general population, household contacts have a…2021 American Transplant Congress
Impact of Once-Daily Extended-Release Tacrolimus Intrapatient Variability in Stable Adolescent and Young Adult Renal Transplant Recipients – 3 Year Results
1Children's Hospital Colorado, Denver, CO, 2Helen DeVos Children’s Hospital, Grand Rapids, MI
*Purpose: Successful renal transplantation requires complex medication regimens that rely heavily on strict adherence to be effective. Variability in immunosuppression exposure, specifically tacrolimus, is associated…2021 American Transplant Congress
Continuous 24-Hour Antithymocyte Globulin (ATG) for Renal Allograft Rejection: Results of a Randomized Controlled Trial
Houston Methodist Hospital, Houston, TX
*Purpose: For acute renal allograft rejection (AR), ATG is generally administered in the inpatient setting because of the need for intravenous access, patient monitoring, and…2021 American Transplant Congress
Association of Immune Cell Markers with Adverse Outcomes in the First 6 Months Post-pediatric Heart Transplantation
*Purpose: Immunosuppression titration post-orthotopic heart transplant (OHT) is limited to trough level monitoring and does not provide data pertaining to overall state of immunosuppression. Additional…
American Transplant Congress abstracts