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American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2022 American Transplant Congress

    Pegloticase for Uncontrolled Gout in Kidney Transplant Recipients: Provisional Data Report of a Multicenter, Open-Label, Efficacy and Safety Study

    A. Abdellatif1, L. Zhao2, K. Cherny2, B. Marder2, J. D. Scandling3, K. Saag4

    1Division of Nephrology, Baylor College of Medicine, Houston, TX, 2Horizon Therapeutics PLC, Deerfield, IL, 3Division of Nephrology, Stanford School of Medicine, Stanford, CA, 4Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    *Purpose: Gout in kidney transplant (KT) recipients can be severe and particularly challenging to manage. Pegloticase co-therapy with immunomodulators improved urate lowering therapy (ULT) response…
  • 2022 American Transplant Congress

    Early Clinical Experience With Nirmatrelvir/ritonavir For Treatment Of Covid-19 In Solid Organ Transplant Recipients

    D. Salerno1, D. Jennings2, N. Lange3, D. Kovac1, T. Shertel1, J. Chen4, J. Hedvat5, J. Scheffert1, R. S. Brown6, M. Pereira7

    1NewYork-Presbyterian Hospital, New York, NY, 2Long Island University, Brooklyn, NY, 3Pharmacy, NewYork-Presbyterian Hospital, New York, NY, 4Columbia University Irving Medical Center, Fort Lee, NJ, 5New York Presbyterian Hospital, Tenafly, NJ, 6Weill Cornell Medicine, New York, NY, 7New York Presbyterian Hospital, New York, NY

    *Purpose: Nirmatrelvir/ritonavir use has not yet been described in solid organ transplant recipients (SOTR) who become infected with COVID-19. The objective of our study was…
  • 2022 American Transplant Congress

    Clinical Outcomes In A Large Transplant Cohort Hospitalized With COVID-19: Mycophenolate Mofetil (MMF) Utilization And Mortality Trends

    R. L. Gottlieb1, M. Askar2, L. Chen3, A. Chandak4, E. Mozaffari3, M. Thrun3, R. Haubrich3

    1Baylor Scott & White Research Institute, Dallas, TX, 2Baylor University Medical Center, Dallas, TX, 3Gilead Sciences, Foster City, CA, 4Certara, New York, NY

    *Purpose: To characterize demographics, treatment patterns, and outcomes among 3,998 transplant patients hospitalized for COVID-19 over 16 months of the pandemic (May ’20-Aug ’21).*Methods: Adult…
  • 2022 American Transplant Congress

    Liver Transplantation – Is There a Life After Death?

    B. Dorobantu

    General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania

    *Purpose: Organ donation and liver transplantation can transform the lack of hope and a terrible loss into a gift - new life that springs from…
  • 2022 American Transplant Congress

    Impact of Early versus Late Initiation of Sirolimus Regimens on Mortality After Kidney Transplantation: Age-Stratified Analyses of Adult Recipients

    A. Santos1, H. Ibrahim1, M. A. Leghrouz1, X. Wen2

    1University of Florida, Gainesville, FL, 2University of Rhode Island, Kingston, FL

    *Purpose: Observational and meta-analytic studies have associated sirolimus with an increased risk of mortality in kidney transplant (KT) recipients (KTRs). We aimed to examine the…
  • 2022 American Transplant Congress

    The Perspective of General Nephrologists Toward Transitions of Care and Management of Patients with Failing Kidney Allografts

    T. Alhamad1, H. Murad1, D. Dadhania2, M. Pavlakis3, S. Parajuli4, B. P. Concepcion5, N. Singh6, N. Murakami7, M. Casey8, M. Ji1, M. Lubetzky9, E. Tantisattamo10, O. Alomar1, A. Faravardeh11, C. Blosser12, A. Basu13, M. Molnar14, G. Gupta15, J. T. Adler16, D. Adey17, K. J. Woodside18, R. Parsons13, K. Lentine19

    1Wash U in St. Louis, Saint Louis, MO, 2Weill Cornell Med, New York, NY, 3Beth Israel, Boston, MA, 4U of Wisconsin, Madison, WI, 5Vanderbilt U, Nashville, TN, 6Northwell Health, Great neck, NY, 7Brigham and Women, Boston, MA, 8MUSC, Charleston, SC, 9Weill Cornell Medicine, New York, NY, 10UCI, Orange, CA, 11SHARP, San Diego, CA, 12U of Washington, Seattle, WA, 13Emory U, Atlanta, GA, 14U of Utah, Salt Lake City, UT, 15VCU, Richmond, VA, 16Surgery, Brigham and Women, Boston, MA, 17UCSF, San Francisco, CA, 18U of Michigan, Ann Arbor, MI, 19Saint Louis U, Saint Louis, MO

    *Purpose: Failing kidney allograft with subsequent return to dialysis is associated with high risk of morbidity and mortality. This project aimed to examine general nephrologist…
  • 2022 American Transplant Congress

    The Role of T Lymphocyte Subsets in Kidney Transplantation

    L. Vagiotas1, A. Xochelli2, E. Sampani3, V. Nikolaidou2, D. Asouchidou2, E. Kasimatis3, N. Antoniadis1, M. Daoudaki4, M. Stangou3, A. Papagianni3, G. Tsoulfas1, A. Fylaktou2

    1Division of Organ Transplantation, Department of Surgery, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, 2National Peripheral Histocompatibility Center, Immunology Department, Hippokration Hospital, Thessaloniki, Greece, 3Department of Nephrology, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, 4Laboratory of Biological Chemistry, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece

    *Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…
  • 2022 American Transplant Congress

    Tacrolimus and Mycophenolic Acid Therapeutic Exposure Targets in Black and White Kidney Transplant Recipients

    K. Tornatore1, K. Attwood1, S. Chang1, A. Gundroo2, B. Murray1

    1Univeristy at Buffalo/SUNY, Buffalo, NY, 2Ohio State Medical Center, Columbus, OH

    *Purpose: Tacrolimus and Mycophenolic Acid(MPA), the preferred immunosuppressive regimen for kidney transplant recipients(KTR), exhibit interpatient pharmacokinetic variability which may impact allograft survival in Black and…
  • 2022 American Transplant Congress

    Real World Experience Utilizing Donor Kidneys at Risk for Acute Kidney Injury with Belatacept Based Maintenance Immunosuppression

    B. Sirandas, A. Chan, M. Eiting, T. Larson, C. Truax, L. Smith

    University of Utah Health, Salt Lake City, UT

    *Purpose: The demand for kidney transplant continues to rise, and limited supply has encouraged acceptance of marginal donor organs, such as those at risk for…
  • 2022 American Transplant Congress

    Direct Comparison of Clinical Outcomes with Belatacept-Based Regimens to Calcineurin Inhibitors Among DCD and/or High KDPI Kidney Transplant Recipients

    A. Rizvi1, M. Kueht2, S. Hussain3, J. Fair2, R. Ramirez4, A. Gamilla-Crudo5, M. Mujtaba5

    1Internal Medicine, Nephrology, University of Texas Medical Branch at Galveston, Galveston, TX, 2Surgery, University of Texas Medical Branch, Galveston, TX, 3University of Texas Medical Branch, Houston, TX, 4Surgery, University of Texas Medical Branch at Galveston, Galveston, TX, 5University of Texas Medical Branch, Galveston, TX

    *Purpose: Belatacept, an inhibitor of the T-cell costimulatory pathway, can be used in recipients of Donation after Cardiac Death (DCD) and high Kidney Donor Profile…
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