Articles tagged "Immunosuppression"

2022 American Transplant Congress
COVID-19 Syndrome After Liver Transplant: Immunosuppression Role and Risk Factors for Mortality
M. M. Pascale¹, F. Frongillo¹, G. Bianco¹, F. Galiandro², E. Nure¹, S. Agnes¹, F. Giovinazzo¹
¹General Surgery and Liver Transplant Unit, Fondazione IRCSS - Policlinico "A. Gemelli", Roma, Italy, ²General Surgery Unit, ULSS3 Serenissima, Venezia, Italy
*Purpose: Data on mortality and immunosuppression role regarding Liver transplant recipients affected by COVID-19 are still under debate. The present study identified risk factors for…
2022 American Transplant Congress
Disruption of B Cell Population is Associated with Increased Infections in Pediatric Transplant Recipients
B. Geng, L. Loop, C. Anterasian, D. Mortazavi, J. Kitsen, C. Collins, K. Newton, E. Ingulli
Pediatrics, UCSD Rady Children's, San Diego, CA
*Purpose: Solid-organ transplant recipients are placed on long-term immunosuppression, preventing graft rejection but increasing the risk of infection. Pediatric transplant recipients are at increased risk…
2022 American Transplant Congress
Accepting Rejection in Liver Transplant Recipients Requiring Renal Replacement Therapy: A Practice Paradigm
S. Farghaly¹, T. Sparkes¹, B. Masters¹, A. Haririan², N. Jakhete³, R. N. Barth⁴, D. Maluf⁵, S. Freedman¹
¹Pharmacy, University of Maryland Medical Center, Baltimore, MD, ²Nephrology, University of Maryland Medical Center, Baltimore, MD, ³Hepatology, University of Maryland Medical Center, Baltimore, MD, ⁴Transplant Surgery, University of Chicago Medical Center, Chicago, IL, ⁵Transplant Surgery, University of Maryland Medical Center, Baltimore, MD
*Purpose: The purpose of this study is to evaluate rejection outcomes in those requiring renal replacement therapy (RRT) after liver transplant.*Methods: This was a single…
2022 American Transplant Congress
The Application of Activated Stem Cells from Human Exfoliated Deciduous Teeth (SHED) in Islet Transplantation for Novel Immunosuppressive Therapy
K. Ishiyama¹, M. Kato², S. Tsunekawa², Y. Miwa¹, K. Iwasaki¹, H. Kamiya², T. Kobayashi¹
¹Division of Kidney Transplantation, Department of Surgery, Aichi Medical University, Nagakute, Japan, ²Division of Diabetes, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan
*Purpose: While various attempts have been made to improve the efficiency of islet transplantation, we have been working on the analysis of the mechanism of…
2022 American Transplant Congress
Chimeric Antigen Receptor Regulatory T Cells (CAR-Tregs) Provide Significantly Greater Modulation of Alloimmune Responses Than Alternative Alloantigen-Specific Treg Strategies
A. S. Kurt¹, P. Ruiz¹, E. Kodela¹, G. Lombardi¹, M. Martinez-Llordella², A. Sanchez-Fueyo¹
¹King's College London, London, United Kingdom, ²Quell Therapeutics, London, United Kingdom
*Purpose: Conferring alloantigen-specificity to ex vivo expanded CD4+CD25+Foxp3+ Tregs increases their capacity to counteract effector alloimmune responses following adoptive transfer into transplant recipients. This has…
2022 American Transplant Congress
Defining the Longitudinal Dynamics of Immune Cells in Blood in the First Year After Pediatric Liver Transplantation (pLTx)
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro¹⁰, J. Pawlowska¹¹, P. Czubkowski¹¹, R. Mikolajczyk¹², U. Baumann¹³, C. Falk¹⁴
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Hannover; Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hannover; Hôpital Necker-Enfants Malades, Paris, France, ⁷Hannover; Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Children's Hospital, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Ospedali Riuniti di Bergamo, Bergamo, Italy, ¹¹Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹²German Center for Infection Research, TTU-IICH Hannover; MHH; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, ¹³Birmingham Children’s Hospital, UK; Division of Pediatric Gastroenterology and Hepatology, MHH, Hannover, Germany, ¹⁴Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed for a deep characterisation of the longitudinal immune dynamics during the first year after pLTx.*Methods: Absolute…
2022 American Transplant Congress
Ixazomib for Desensitization (IXADES): Results of a Phase II Clinical Trial
N. Wilson¹, S. R. Reese², L. Ptak³, F. Aziz², S. Parajuli², V. Jucaud⁴, S. Denham⁴, A. Mishra⁵, P. Hematti⁵, A. Djamali²
¹University of Wisconsin, Madison, WI, ²Medicine, University of Wisconsin, Madison, WI, ³Administration, University of Wisconsin, Madison, WI, ⁴Terasaki Institute, Los Angeles, CA, ⁵UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI
*Purpose: Ixazomib is a second-generation oral proteasome inhibitor, FDA approved for the treatment of refractory multiple myeloma. The purpose of the study was (1) to…
2022 American Transplant Congress
Variable Course of Hepatitis A Virus Infection in Solid Organ Transplant Recipients
A. Vostal¹, J. Husson², A. Shishido¹, N. Jakhete³, E. Moore⁴, X. Wen⁵, A. Amoroso², R. Meier⁶, E. Wilson², K. K. Saharia²
¹Div. of Infectious Diseases, Univ. of Maryland Medical Center, Baltimore, MD, ²Div. of Infectious Diseases, Univ. of Maryland School of Medicine and Institute of Human Virology, Baltimore, MD, ³Div. of Hepatology, Univ. of Maryland School of Medicine, Baltimore, MD, ⁴Dept of Surgery, Brooklyn Hospital Center, Brooklyn, NY, ⁵Dept. of Surgery, Univ. of Florida, Gainesville, FL, ⁶Dept. of Surgery, Univ. of Maryland School of Medicine, Baltimore, MD
*Purpose: Although Hepatitis A virus (HAV) infection is typically a self-limited disease in immunocompetent individuals, the natural history and viral kinetics of HAV in solid…
2022 American Transplant Congress
Humoral and Cellular Immunity 6 Months After SARS-CoV-2 Infection in Solid-Organ Transplant Recipients
S. Morris¹, S. Courel², S. Pallikkuth³, S. Pahwa³, A. Fernandez⁴, S. Anjan¹, G. Guerra⁵, M. Alcaide¹, Y. Natori¹
¹Division of Infectious Disease, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, ²University of Miami Miller School of Medicine, Miami, FL, ³Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, ⁴Infectious Disease Associates of Tampa Bay, Tampa Bay, FL, ⁵University of Miami Jackson Memorial Hospital, Miami, FL
*Purpose: The purpose of this study was to evaluate long term humoral and cellular immunity generated following SARS-CoV-2 infection in solid organ transplant recipients (SOTR).*Methods:…
2022 American Transplant Congress
Randomized, Phase 4 Study Evaluating the Pharmacokinetics and Tolerability of the New Tacrolimus Tablet Formulation (Tacrobell Tab) in Kidney Transplant Recipients
A. Han¹, E. Cho¹, H. Y. Woo¹, C. Ara¹, H. Lee², Y. Kim³, Y. Park⁴, J. Oh⁴, S. Min¹, J. Ha¹
¹Department of Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Nephrology, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Clnical Pharmacology, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Previous twice-a-day tacrolimus formulations available were capsular and of limited dose formulations (0.5mg, 1mg). Recently a new tablet formulation of tacrolimus with more diverse…