Articles tagged "Immunosuppression"

2022 American Transplant Congress
The Perspective of General Nephrologists Toward Transitions of Care and Management of Patients with Failing Kidney Allografts
T. Alhamad¹, H. Murad¹, D. Dadhania², M. Pavlakis³, S. Parajuli⁴, B. P. Concepcion⁵, N. Singh⁶, N. Murakami⁷, M. Casey⁸, M. Ji¹, M. Lubetzky⁹, E. Tantisattamo¹⁰, O. Alomar¹, A. Faravardeh¹¹, C. Blosser¹², A. Basu¹³, M. Molnar¹⁴, G. Gupta¹⁵, J. T. Adler¹⁶, D. Adey¹⁷, K. J. Woodside¹⁸, R. Parsons¹³, K. Lentine¹⁹
¹Wash U in St. Louis, Saint Louis, MO, ²Weill Cornell Med, New York, NY, ³Beth Israel, Boston, MA, ⁴U of Wisconsin, Madison, WI, ⁵Vanderbilt U, Nashville, TN, ⁶Northwell Health, Great neck, NY, ⁷Brigham and Women, Boston, MA, ⁸MUSC, Charleston, SC, ⁹Weill Cornell Medicine, New York, NY, ¹⁰UCI, Orange, CA, ¹¹SHARP, San Diego, CA, ¹²U of Washington, Seattle, WA, ¹³Emory U, Atlanta, GA, ¹⁴U of Utah, Salt Lake City, UT, ¹⁵VCU, Richmond, VA, ¹⁶Surgery, Brigham and Women, Boston, MA, ¹⁷UCSF, San Francisco, CA, ¹⁸U of Michigan, Ann Arbor, MI, ¹⁹Saint Louis U, Saint Louis, MO
*Purpose: Failing kidney allograft with subsequent return to dialysis is associated with high risk of morbidity and mortality. This project aimed to examine general nephrologist…
2022 American Transplant Congress
The Role of T Lymphocyte Subsets in Kidney Transplantation
L. Vagiotas¹, A. Xochelli², E. Sampani³, V. Nikolaidou², D. Asouchidou², E. Kasimatis³, N. Antoniadis¹, M. Daoudaki⁴, M. Stangou³, A. Papagianni³, G. Tsoulfas¹, A. Fylaktou²
¹Division of Organ Transplantation, Department of Surgery, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ²National Peripheral Histocompatibility Center, Immunology Department, Hippokration Hospital, Thessaloniki, Greece, ³Department of Nephrology, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ⁴Laboratory of Biological Chemistry, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece
*Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…
2022 American Transplant Congress
Tacrolimus and Mycophenolic Acid Therapeutic Exposure Targets in Black and White Kidney Transplant Recipients
K. Tornatore¹, K. Attwood¹, S. Chang¹, A. Gundroo², B. Murray¹
¹Univeristy at Buffalo/SUNY, Buffalo, NY, ²Ohio State Medical Center, Columbus, OH
*Purpose: Tacrolimus and Mycophenolic Acid(MPA), the preferred immunosuppressive regimen for kidney transplant recipients(KTR), exhibit interpatient pharmacokinetic variability which may impact allograft survival in Black and…
2022 American Transplant Congress
Real World Experience Utilizing Donor Kidneys at Risk for Acute Kidney Injury with Belatacept Based Maintenance Immunosuppression
B. Sirandas, A. Chan, M. Eiting, T. Larson, C. Truax, L. Smith
University of Utah Health, Salt Lake City, UT
*Purpose: The demand for kidney transplant continues to rise, and limited supply has encouraged acceptance of marginal donor organs, such as those at risk for…
2022 American Transplant Congress
Direct Comparison of Clinical Outcomes with Belatacept-Based Regimens to Calcineurin Inhibitors Among DCD and/or High KDPI Kidney Transplant Recipients
A. Rizvi¹, M. Kueht², S. Hussain³, J. Fair², R. Ramirez⁴, A. Gamilla-Crudo⁵, M. Mujtaba⁵
¹Internal Medicine, Nephrology, University of Texas Medical Branch at Galveston, Galveston, TX, ²Surgery, University of Texas Medical Branch, Galveston, TX, ³University of Texas Medical Branch, Houston, TX, ⁴Surgery, University of Texas Medical Branch at Galveston, Galveston, TX, ⁵University of Texas Medical Branch, Galveston, TX
*Purpose: Belatacept, an inhibitor of the T-cell costimulatory pathway, can be used in recipients of Donation after Cardiac Death (DCD) and high Kidney Donor Profile…
2022 American Transplant Congress
Thymoglobulin Induction Protocol: Quality Improvement Project via Clinical Audit
S. Mouawad¹, J. Dann¹, A. Kumar², S. Rao³
¹University of Virginia Health System, Charlottesville, VA, ²Nephrology, University of Virginia, Charlottesville, VA, ³University of Virginia, Charlottesville, VA
*Purpose: The aim of our study was to analyze the adequacy of the thymoglobulin (rATG) induction protocol for the expanding and higher complexity kidney transplant…
2022 American Transplant Congress
Comparing Long-Term Outcomes of Steroid-Based versus Steroid-Avoidant Immunosuppression in Pediatric Kidney Transplant Recipients
N. Hayde¹, E. Blanchette², J. Zhang³, M. Chandran², M. Bock², S. Galbiati³, T. Blydt-Hansen⁴
¹Montefiore Medical Center, Bronx, NY, ²Children's Hospital Colorado, Aurora, CO, ³Emmes Corporation, Rockville, MD, ⁴University of British Columbia, Vancouver, BC, Canada
*Purpose: With increasing use of potent immunosuppressant (IS) medications, steroid-avoidant (SA) regimens are now commonly used for pediatric kidney transplant recipients (pKTs) to avoid potential…
2022 American Transplant Congress
Case-Control Study of Belatacept as Maintenance Immunosuppression in Kidney Transplant Recipients Living with HIV
M. Tucker, C. Foppiano Palacios, E. Cohen, S. Virmani, P. Trubin, L. A-Barakat, M. M. Azar, M. Malinis
Yale School of Medicine, New Haven, CT
*Purpose: Belatacept has been increasingly used in kidney transplant recipients (KTR) as a calcineurin-inhibitor (CNI) sparing agent. There are little data on belatacept use in…
2022 American Transplant Congress
Everolimus versus Mycophenolate in Simultaneous Pancreas and Kidney Transplantation: Progression of Diabetic Retinopathy in a Prospective Randomized Trial
B. Hagerf¹, Z. Hladíková¹, M. Zahradnická¹, K. Kesslerová², T. Sosna², P. Girman¹, F. Saudek¹
¹Diabetes Centre, IKEM, Prague, Czech Republic, ²Ophtalmology Clinic, Thomayer Hospital, Prague, Czech Republic
*Purpose: mTOR inhibitors are known for their antiangiogenic effect. We compared the impact of everolimus (E) and mycophenolic acid (MPA) on the course of diabetic…
2022 American Transplant Congress
Belatacept Conversion in Proteinuric Kidney Transplant Recipients: Effects in a Prospective Trial and a Retrospective Cohort
O. Efe¹, A. Al Jurdi¹, D. Wojciechowski², K. Safa¹, H. Gilligan¹, A. Chandraker³, J. Azzi³, A. Weins³, L. V. Riella¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²UT Southwestern Medical Center, Dallas, TX, ³Brigham and Women's Hospital, Boston, MA
*Purpose: Proteinuria after kidney transplantation is associated with worse allograft outcomes. B7-1 expression by podocytes has been linked to proteinuria by inducing podocyte migration which…