Articles tagged "Immunosuppression"

2022 American Transplant Congress
Clinical Outcomes In A Large Transplant Cohort Hospitalized With COVID-19: Mycophenolate Mofetil (MMF) Utilization And Mortality Trends
R. L. Gottlieb¹, M. Askar², L. Chen³, A. Chandak⁴, E. Mozaffari³, M. Thrun³, R. Haubrich³
¹Baylor Scott & White Research Institute, Dallas, TX, ²Baylor University Medical Center, Dallas, TX, ³Gilead Sciences, Foster City, CA, ⁴Certara, New York, NY
*Purpose: To characterize demographics, treatment patterns, and outcomes among 3,998 transplant patients hospitalized for COVID-19 over 16 months of the pandemic (May ’20-Aug ’21).*Methods: Adult…
2022 American Transplant Congress
Liver Transplantation – Is There a Life After Death?
B. Dorobantu
General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania
*Purpose: Organ donation and liver transplantation can transform the lack of hope and a terrible loss into a gift - new life that springs from…
2022 American Transplant Congress
Impact of Early versus Late Initiation of Sirolimus Regimens on Mortality After Kidney Transplantation: Age-Stratified Analyses of Adult Recipients
A. Santos¹, H. Ibrahim¹, M. A. Leghrouz¹, X. Wen²
¹University of Florida, Gainesville, FL, ²University of Rhode Island, Kingston, FL
*Purpose: Observational and meta-analytic studies have associated sirolimus with an increased risk of mortality in kidney transplant (KT) recipients (KTRs). We aimed to examine the…
2022 American Transplant Congress
The Perspective of General Nephrologists Toward Transitions of Care and Management of Patients with Failing Kidney Allografts
T. Alhamad¹, H. Murad¹, D. Dadhania², M. Pavlakis³, S. Parajuli⁴, B. P. Concepcion⁵, N. Singh⁶, N. Murakami⁷, M. Casey⁸, M. Ji¹, M. Lubetzky⁹, E. Tantisattamo¹⁰, O. Alomar¹, A. Faravardeh¹¹, C. Blosser¹², A. Basu¹³, M. Molnar¹⁴, G. Gupta¹⁵, J. T. Adler¹⁶, D. Adey¹⁷, K. J. Woodside¹⁸, R. Parsons¹³, K. Lentine¹⁹
¹Wash U in St. Louis, Saint Louis, MO, ²Weill Cornell Med, New York, NY, ³Beth Israel, Boston, MA, ⁴U of Wisconsin, Madison, WI, ⁵Vanderbilt U, Nashville, TN, ⁶Northwell Health, Great neck, NY, ⁷Brigham and Women, Boston, MA, ⁸MUSC, Charleston, SC, ⁹Weill Cornell Medicine, New York, NY, ¹⁰UCI, Orange, CA, ¹¹SHARP, San Diego, CA, ¹²U of Washington, Seattle, WA, ¹³Emory U, Atlanta, GA, ¹⁴U of Utah, Salt Lake City, UT, ¹⁵VCU, Richmond, VA, ¹⁶Surgery, Brigham and Women, Boston, MA, ¹⁷UCSF, San Francisco, CA, ¹⁸U of Michigan, Ann Arbor, MI, ¹⁹Saint Louis U, Saint Louis, MO
*Purpose: Failing kidney allograft with subsequent return to dialysis is associated with high risk of morbidity and mortality. This project aimed to examine general nephrologist…
2022 American Transplant Congress
The Role of T Lymphocyte Subsets in Kidney Transplantation
L. Vagiotas¹, A. Xochelli², E. Sampani³, V. Nikolaidou², D. Asouchidou², E. Kasimatis³, N. Antoniadis¹, M. Daoudaki⁴, M. Stangou³, A. Papagianni³, G. Tsoulfas¹, A. Fylaktou²
¹Division of Organ Transplantation, Department of Surgery, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ²National Peripheral Histocompatibility Center, Immunology Department, Hippokration Hospital, Thessaloniki, Greece, ³Department of Nephrology, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ⁴Laboratory of Biological Chemistry, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece
*Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…
2022 American Transplant Congress
Artificial Intelligence Based Dosing of Tacrolimus in Liver Transplantation: Prospective, Randomized Phase 2 Trial
A. Zarrinpar¹, C. Ho², C. Warren¹, J. Khong², M. Lee², S. Duarte¹, K. Andreoni¹, M. Johnson¹, N. Battula³, D. McKimmy¹, T. Beduschi¹
¹Surgery, University of Florida, Gainesville, FL, ²Mechanical and Aerospace Engineering, University of California, Los Angeles, CA, ³Surgery, University of Oklahoma, Oklahoma City, OK
*Purpose: Inter- and intra-individual variability in calcineurin dose requirements necessitates empirical clinician-titrated dosing that frequently results in deviation from target ranges, particularly during the critical…
2022 American Transplant Congress
Clinically Available Immunosuppressive Agents Prolong Pig-to-Primate Kidney Xenograft Survival
I. J. Anwar¹, Q. Gao¹, I. DeLaura¹, J. Yoon¹, R. Baldi¹, M. Youd², K. Stiede², K. Hall², S. Knechtle¹, J. Kwun¹
¹Surgery, Duke Transplant Center, Durham, NC, ²eGenesis Inc, Cambridge, MA
*Purpose: Most immunosuppressive regimens used in Pig-To-Primate Xenotransplantation contain anti-CD154 agents, compounds that are currently not FDA-approved. The aim of this study was to assess…
2022 American Transplant Congress
Long Term Longitudinal TTV Measurements in Lung Transplant Recipients
E. Gore¹, C. Rondaan¹, E. A. Verschuuren², L. Gard¹, H. G. Niesters¹, C. van Leer-Buter¹
¹Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands, ²Department of Pulmonary Diseases and Tuberculosis, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands
*Purpose: To investigate how levels of Torque Teno Virus (TTV), a virus which has been proposed as a marker for immunosuppression change over a period…
2022 American Transplant Congress
Thymoglobulin Induction Protocol: Quality Improvement Project via Clinical Audit
S. Mouawad¹, J. Dann¹, A. Kumar², S. Rao³
¹University of Virginia Health System, Charlottesville, VA, ²Nephrology, University of Virginia, Charlottesville, VA, ³University of Virginia, Charlottesville, VA
*Purpose: The aim of our study was to analyze the adequacy of the thymoglobulin (rATG) induction protocol for the expanding and higher complexity kidney transplant…
2022 American Transplant Congress
Comparing Long-Term Outcomes of Steroid-Based versus Steroid-Avoidant Immunosuppression in Pediatric Kidney Transplant Recipients
N. Hayde¹, E. Blanchette², J. Zhang³, M. Chandran², M. Bock², S. Galbiati³, T. Blydt-Hansen⁴
¹Montefiore Medical Center, Bronx, NY, ²Children's Hospital Colorado, Aurora, CO, ³Emmes Corporation, Rockville, MD, ⁴University of British Columbia, Vancouver, BC, Canada
*Purpose: With increasing use of potent immunosuppressant (IS) medications, steroid-avoidant (SA) regimens are now commonly used for pediatric kidney transplant recipients (pKTs) to avoid potential…