ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunoglobulins (Ig)"

  • 2016 American Transplant Congress

    Enabled PRA and Precision PRA: Alternatives to cPRA as Desensitization Trial Endpoints.

    E. Woodle, M. Pando Rigal, S. Tremblay, A. Girnita.

    U of Cincinnati, Cincinnati; Mayo Clinic Scottsdale, Scottsdale.

    Transplant (Transplant) rate is an optimal endpoint in desensitization (DS) trials in HLA sensitized Txp candidates, however, for waitlisted Txp candidates, wait time heterogeneity compromises…
  • 2016 American Transplant Congress

    Long-Term Follow-Up of Renal Transplant Recipients (RTR) Treated with IVIG for De Novo Donor Specific Antibodies (DSA).

    R. Knight,1 S. Patel,1 J. Loucks-DeVos,2 S. Kuten,1 A. Gaber.1

    1Houston Methodist Hospital, Houston, TX; 2Kansas University Medical Center, Kansas City, KS.

    Intravenous immune globulin (IVIG) may be beneficial for pre-emptive treatment of de novo DSA in RTR without biopsy-proven acute rejection (AR). Herein, we present long-term…
  • 2016 American Transplant Congress

    MHC/HLA-Specific IgE in Allotransplantation.

    A. Farkas,1 U. Baranyi,1 L. Unger,1 B. Mahr,1 K. Hock,1 N. Pilat,1 H. Regele,2 M. Wahrmann,3 G. Böhmig,3 R. Valenta,4 T. Wekerle.1

    1Dept. of Surgery, Medical University of Vienna, Vienna, Austria; 2Clin. Inst. of Pathology, Medical University of Vienna, Vienna, Austria; 3Dept. of Internal Medicine III, Medical University of Vienna, Vienna, Austria; 4Dept. of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.

    Background: Donor-specific antibodies (DSA) are recognized as important factors in determining outcome in renal transplantation.Typically DSAs of the IgG isotype are measured, but little is…
  • 2016 American Transplant Congress

    The Effect of Tocilizmab Treatment (TCZ-Rx) on Total IgG and Anti-CMV-IgG Levels in HLA-Sensitized (HS) Kidney Transplant Patients.

    B.-H. Shin, S. Ge, J. Choi, J. Kahwaji, A. Vo, A. Petrosyan, S. Jordan, M. Toyoda.

    Transplant Immunology Lab, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: TCZ has anti-B cell and anti-inflammatory properties. We have reported its successful use for pre-transplant (Tx) desensitization (DES) and treatment of ABMR. We also…
  • 2016 American Transplant Congress

    Inhibitory FcγRIIB Functionally Inhibits Donor-Reactive CD8+ Memory T Cell Responses Following Transplantation.

    D. Pinelli, M. Wagener, D. Liu, I. Badell, M. Ford.

    Emory Transplant Center, Emory University, Atlanta, GA.

    Fc receptors are expressed by many types of immune cells and bind to the constant portion of immunoglobulin to mediate their effector functions. The inhibitory…
  • 2015 American Transplant Congress

    Plasmapharesis, Intravenous Immunoglobulin and Rituximab Successfully Treat Recurrent Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC-2) After Liver Transplantation

    H. Elsiesy,1 F. Abaalkhail,1 W. Alhamoudi,1,2 H. Alhussaini,3 M. Alsebayel,1 D. Broring,1 M. Shagrani.1

    1Liver Trasplantation, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; 2Gastroenterology, King Saud University, Riyadh, Saudi Arabia; 3Pathology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.

    Background:Allo-immune mediated BSEP dysfunction may occur after liver transplantation in PFIC2 patients leading to a PFIC2 like phenotype. The IgG antibodies are reactive toward a…
  • 2015 American Transplant Congress

    Immunodeficiency Assessment in Pediatric Intestinal Failure Patients

    J. Garcia,1 T. Beduschi,1 C. Biaggi,2 E. Perez,2 A. Tekin,1 M. McGetrick,3 L. Cubley,1 P. Ruiz,1 J. Fan,1 S. Nishida,1 G. Selvaggi,1 R. Vianna.1

    1Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL; 2Pediatrics, University of Miami Miller School of Medicine, Miami, FL; 3University of Miami Miller School of Medicine, Miami, FL.

    Intestinal failure (IF) is a clinical condition for which intestinal transplantation may be indicated. Patients without enteral autonomy have an increased risk of malnutrition which…
  • 2015 American Transplant Congress

    Characteristics of IgGs Produced in Neu5Gc and α1-3 Gal Double Knock-Out Pigs

    A. Salama,1,2 S. Conchon,1 A. Perota,3 B. Martinet,1 J.-P. Judor,1 G. Evanno,1 S. Le-Bas Bernardet,1 L. Le Berre,1 J. Hervouet,1 D. Minault,1 J.-P. Concordet,4 E. Dugast,1 B. Vanhove,1 J. Abadie,5 N. Gaide,5 I. Lagutina,3 R. Duchi,3 G. Lazzari,3 D. Sachs,6 O. Gauthier,7 S. Brouard,1 E. Cozzi,8 G. Blancho,1 H. Perreault,9 J.-M. Bach,10 C. Galli,3,11 J.-P. Soulillou.1

    1INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; 2Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; 3Avantea, Laboratory of Reproductive Technologies, Cremona, Italy; 4INSERM U565, CNRS UMR7196, MNHN USM503, Paris, France; 5AMaROC, ONIRIS, Nantes, France; 6Massachusetts General Hospital, Transplantation Biology Research Center, Boston, MA; 7Centre de Recherche et d'Investigation Préclinique, ONIRIS, Nantes, France; 8Padua General Hospital and Consortium for Research in Organ Transplantation, Padua, Italy; 9Chemistry Department, University of Manitoba, Winnipeg, Canada; 10IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; 11Dept. of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.

    Xenotransplantation offers a large number of potential applications, including solid organs, pancreatic islets, acellular tissues such as heart valves and skin grafts, and new bioreagents…
  • 2015 American Transplant Congress

    Anti-Thymocyte Globulin Induction in Infected Mechanical Circulatory Support Patients: Is It Safe?

    G. Jamero, J. Moriguchi, L. Czer, M. Kittleson, S. Siddiqui, F. Liou, D. Arman, L. Lam, D. Chang, P. Zakowski, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Purpose: The use of mechanical circulatory assist devices (MCSD) have been increasing over the past several years. Driveline infections (DLI) are one of the most…
  • 2015 American Transplant Congress

    The Effects of Donor Specific Anti- Human Leukocyte Antigen Antibodies Late After Heart Transplantation

    M. Kittleson, J. Patel, F. Liou, S. Siddiqui, A. Fong, M. Johnson, D. Chang, L. Czer, F. Esmailian, N. Reinsmoen, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Purpose: The development of anti-HLA antibodies following heart transplantation has been associated with poor outcomes, including lower survival and increased risk for the development of…
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