ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunoglobulins (Ig)"

  • 2022 American Transplant Congress

    The Evolution of Hypogammaglobulinemia in Kidney Transplant Recipients and Its Associated Risk Factors

    E. Jo1, S. Min2, A. Han3

    1Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, 2Surgery, Seoul National University College of Medicine, Seoul, Kosovo, Republic of, 3Seoul National University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Hypogammaglobulinemia (HGG) has been extensively studied to identify a biological marker for infection. According to Florescu et al. (2013), a meta-analysis of 18 clinical…
  • 2022 American Transplant Congress

    Desensitization Protocol Consisting of High-Dose Intravenous Immunoglobulin, Plasmapheresis, and Rituximab in Highly Sensitized Kidney Transplant Recipients

    M. Okada, T. Hiramitsu, T. Tomosugi, K. Futamura, S. Narumi, N. Goto, Y. Watarai

    Nagoya Daini Red Cross Hospital, Nagoya, Japan

    *Purpose: In HLA incompatible kidney transplantation, donor-specific HLA antibody often causes antibody-mediated rejection (AMR). To prevent AMR, we adopted a preoperative desensitization protocol including high-dose…
  • 2022 American Transplant Congress

    Daratumumab Therapy Achieves Dialysis Independence in Kidney Transplant Recipients with Resistant Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits

    P. Yenebere, R. Daloul

    The Ohio State University, Columbus, OH

    *Purpose: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a unique cause for monoclonal gammopathy of renal significance with overall poor prognosis. Patients are frequently…
  • 2022 American Transplant Congress

    Immunoglobulin M (IgM) Inhibits Replication of SARS-CoV-2 In Vero E6 Cells In Vitro and Delays Disease in K18-hACE2 Mice Infected with SARSCoV-2 In Vivo

    P. Chhabra1, B. Mann2, M. Ma1, S. Feldman3, K. L. Brayman1

    1Department of Surgery, University of Virginia Health System, Charlottesville, VA, 2Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA, 3Center for Comparative Medicine, University of Virginia Health System, Charlottesville, VA

    *Purpose: To determine if IgM has a direct effect in preventing SARS-CoV-2 replication in Vero E6 cells, and delaying or preventing disease in infected K18-hACE2…
  • 2022 American Transplant Congress

    Management of Hepatitis B Positive Donors in Liver Transplant

    M. Tilley1, T. A. Sparkman2, K. Gutierrez2

    1Pharmacy, UAB, Birmingham, AL, 2UAB, Birmingham, AL

    *Purpose: In an effort to expand the pool of solid organ transplant donors, patients with end stage liver disease may receive an organ from a…
  • 2022 American Transplant Congress

    Outcome of Donor Derived and Community Acquired West Nile Infections in Kidney Transplant Recipients

    R. K. Thimmisetty1, G. Larrieux2, S. Wilson2, F. Barrantes1, S. Kundeling1, J. Kumar1

    1Renal Medicine Associates, Albuquerque, NM, 2Presbyterian Health Services, Albuquerque, NM

    *Purpose: Donor derived West Nile Virus(WNV) Infections can occur but rare. We are presenting four cases that were seen at our transplant center*Methods: Case 1:…
  • 2021 American Transplant Congress

    Dynamics of IgG Subclass as a Mechanism of Desensitization Using Rituximab for Presensitized Patients Undergoing Living Related Liver Transplantation

    H. Egawa1, K. Ide2, T. Ishizuka3, H. Ohdan4, Y. Kotera1, T. Kato1, A. Ohmori1, Y. Hirata1, G. Shibuya1, S. Yamashita1, S. Ariizumi1

    1Tokyo Women's Medical University, Tokyo, Japan, 2Surgery, Hiroshima University, Hiroshima, Japan, 3Clinical Laboratory, Tokyo Women's Medical University, Tokyo, Japan, 4Hiroshima University, Hiroshima, Japan

    *Purpose: Although impact of preformed HLA-related donor specific antibody (DSA) and necessity of desensitization in liver transplantation (LT) has been recognized, mechanisms of desensitization in…
  • 2021 American Transplant Congress

    Kidney Transplant Associated Allergy Transfer After Living Donation

    K. López-Vega, S. Davis

    Division of Renal Diseases and Hypertension, Anschutz Medical Campus, University of Colorado, Aurora, CO

    *Purpose: Donor to recipient IgE-mediated food allergy transfer has been described in non-kidney solid organ transplant. Here, we report a novel case of an adult…
  • 2021 American Transplant Congress

    Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-mediated Rejection

    S. Clotet-Freixas1, M. Kotlyar2, C. M. McEvoy1, C. Pastrello2, S. Rodríguez-Ramírez1, S. Farkona1, H. Cardinal3, M. Dieudé3, M. Hébert3, Y. Li1, O. Famure1, P. Chen1, S. Kim1, E. Chan4, I. Jurisica2, R. John1, A. Chruscinski1, A. Konvalinka1

    1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 4Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR) causes >50% of late kidney graft losses. Although donor-specific antibodies (DSA) against HLA cause AMR, antibodies against non-HLA antigens are also…
  • 2021 American Transplant Congress

    Use of a Novel Bead-based Assay to Measure the Impact of Imlifidase on ABO IgG Antibodies

    A. Halpin1, B. Motyka2, T. Ellis2, J. Pearcey2, T. L. Lowary3, A. Runström4, L. Winstedt4, R. Bockermann4, S. Järnum4, A. Robertson4, L. J. West5

    1Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta and Alberta Precision Laboratories, Edmonton, AB, Canada, 2Department of Pediatrics, University of Alberta, Edmonton, AB, Canada, 3Department of Chemistry, University of Alberta, Edmonton, AB, Canada, 4Hansa Biopharma, Lund, Sweden, 5Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada

    *Purpose: The accurate assessment and measurement of ABO antibodies (ABO-Ab) is a critical component of ABO-incompatible (ABOi) transplantation. ABO-Ab comprise both IgG and IgM, which…
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