Articles tagged "Immunoglobulins (Ig)"

2020 American Transplant Congress
IgA Nephropathy Outcomes after Kidney Transplantation in an Early Corticosteroid Withdrawal Center
S. Kurian¹, S. Spierling², B. Barrick¹, J. Rice¹, J. Case¹, C. Marsh¹
¹Scripps Center for Organ and Cell Transplantation, La Jolla, CA, ²Scripps Whittier Diabetes Institute, La Jolla, CA
*Purpose: IgA nephropathy (IgAN) is the most frequent biopsy-proven primary glomerular disease. Recurrent IgA after transplantation often leads to allograft loss. A lower risk of…
2020 American Transplant Congress
Conversion to Belatacept (BLT)- from Calcineurin Inhibitor (CNI)-Based Immunosuppression During the First Year Post-Transplant (<1yr Tx) Increases Risk for CMV Infection Through Inhibition of Anti-CMV Humoral Immunity
B. Shin, N. Ammerman, S. Sethi, A. Vo, S. C. Jordan, M. Toyoda
Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: We have shown a higer CMV infection rate in kidney Tx patients (KTx Pts) who were converted to BLT 1yr post-Tx. Viral infections are…
2020 American Transplant Congress
Single Center Experience of Valganciclovir and Adjunctive CMV IVIG for the Treatment of CMV Infection in Lung Transplant Recipients
A. A. Fernandez¹, N. Sinha², M. Loebe², J. Glaze², S. Manickavel², M. Fernandez², T. Pastrana², J. Simkins³, J. Camargo³, M. I. Morris³, L. Abbo³, Y. Natori³
¹Infectious Disease, University of Miami Jackson Memorial Hospital, Miami, FL, ²University of Miami Jackson Memorial Hospital, Miami, FL, ³Transplant Infectious Disease, University of Miami Jackson Memorial Hospital, Miami, FL
*Purpose: Cytomegalovirus(CMV) infection happens commonly and causes significant morbidity in lung transplant (LTx) recipients. The use of CMV hyperimmune globulin (CMVIg) as an adjunctive treatment…
2019 American Transplant Congress
A Clinical Analysis for Low-Dose Immunoglobulin United with Plasmapheresis in High Sensitization Renal Transplantation Recipients
L. Xu¹, J. Zhang²
¹Chinese PLA General Hospital Eighth Medical Centre, Beijing, China, ²Nursing Department, Chinese PLA General Hospital, Beijing, China
*Purpose: To analyze the role of low-dose intravenous immunoglobulin (IVIG) united with plasmapheresis in high sensitization renal transplantation recipients.*Methods: Four patients with high levels of…
2019 American Transplant Congress
Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy
M. Ma, P. Chhabra, K. Brayman
Surgery, University of Virginia, Charlottesville, VA
*Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…
2019 American Transplant Congress
Successful Use of Hizentra to Address BK Viremia in Pediatric Transplant Population
K. Gruenkemeyer, E. Wood, A. Beck, C. Belsha
Pediatric Nephrology, Saint Louis University, Saint Louis, MO
*Purpose: BK viremia is an important problem in the pediatric renal transplant population leading to increased risk for viral associated nephropathy in the transplant. Early…
2019 American Transplant Congress
Extracellular Vesicles (EV) Mediate Antibody-Independent Tubular Senescence via Cyclin-Dependent Kinase Inhibitors p21/p16 in Antibody-Mediated Rejection (AMR)
C. Divella¹, A. Stasi¹, R. Franzin¹, F. Sallustio², C. Curci¹, G. Merlotti³, M. Quaglia³, L. Gesualdo¹, V. Cantaluppi¹, G. Castellano¹
¹Emergency and Organ Transplantation, University of Bari, Bari, Italy, ²Emergency and Organ Transplantation / Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy, ³Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
*Purpose: Recent data suggest a strong correlation between kidney injury and the occurrence of accelerated senescence process, known as “Inflammaging”. However, the role of TEC…
2019 American Transplant Congress
Alloreactive B Cells in Transplant Tolerant Recipients Cannot Differentiate into Antibody-Secreting Cells but Can Suppress Donor-Specific IgG Production By Naïve B Cells
S. H. Khiew¹, J. Chen¹, D. Jain¹, Q. Wang¹, D. Yin¹, M. Alegre², A. S. Chong¹
¹Department of Surgery, Section of Transplant, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Donor specific transplantation tolerance has long been the goal of clinical transplantation. Clinical observations suggest that donor-specific antibodies (DSA) are a major cause of…
2019 American Transplant Congress
B Cell Immunophenotypes in Transplantation
M. Cascalho¹, M. de Mattos-Barbosa², E. A. Farkash³, J. L. Platt²
¹University of Michigan, Ann Arbor, MI, ²Surgery, University of Michigan, Ann Arbor, MI, ³Pathology, University of Michigan, Ann Arbor, MI
*Purpose: B cells and B cell responses have been associated with favorable outcomes of transplantation in some setting and unfavorable outcomes in others. For example,…
2019 American Transplant Congress
Next Gen ABO Antibody Assessment: Development of a Bead-Based ABO Antibody Detection Assay
A. Halpin¹, J. Pearcey², B. Motyka², S. Maier², J. Zhou³, T. L. Lowary⁴, C. W. Cairo⁴, L. J. West¹
¹Dept of Pediatrics, Dept of Laboratory Medicine, GlycoNet, ATI, CDTRP, University of Alberta, Edmonton, AB, Canada, ²Dept of Pediatrics, ATI, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada, ³Dept of Laboratory Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Dept of Chemistry, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada
*Purpose: Accurate characterization of ABO antibodies (ABO-Ab) is critical to assess their impact in ABO incompatible (ABOi) transplantation. The current ABO-Ab detection method using erythrocyte…