ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunoglobulins (Ig)"

  • 2020 American Transplant Congress

    Novel micro-RNA and Microbiome Signature Profiles as Biomarkers for Predicting the Risk of Autoimmune Type 1 Diabetes Development

    P. Chhabra1, G. Ricardo1, A. Spano2, V. Mas1, M. Timko2, K. Brayman1

    1Dept of Surgery, University of Virginia Health System, Charlottesville, VA, 2Dept of Biology, University of Virginia Health System, Charlottesville, VA

    *Purpose: To identify reliable microRNA (miRNA) and microbiome biomarkers for predicting risk of autoimmune beta-cell destruction in type 1 diabetes (T1D) and to investigate alterations…
  • 2020 American Transplant Congress

    Renal Safety of Entecavir and Tenofovir with Hepatitis B Immunoglobulin in Liver Transplant Patients

    J. Lee1, E. Kim1, S. Yang1, D. Kim2, S. Kim1, J. Park3, H. Choi4, B. Kim3, D. Joo1, M. Kim1, S. Kim1, J. Lee1

    1Department of Transplantation Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 2Department of Surgery, Wonju Severance Hospital, Yonsei University College of Medicine, Wonju, Korea, Republic of, 3Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Combination of potent nucleos(t)ide analougues (NAs) and hepatitis B immunoglobulin is recommended after liver transplantation for the prevention of hepatitis B virus (HBV) recurrence.…
  • 2020 American Transplant Congress

    Long-Term Islet Allo- and Xenograft Survival is Promoted by Immunoglobulin M Immunotherapy

    M. Ma, K. Brayman, P. Chhabra

    Department of Surgery, University of Virginia Health System, Charlottesville, VA

    *Purpose: To investigate if islet allo- and xenotransplant rejection is mitigated by IgM immunotherapy.*Methods: a) New onset diabetic NOD mice (n=14) were treated with IgM…
  • 2019 American Transplant Congress

    Successful Use of Hizentra to Address BK Viremia in Pediatric Transplant Population

    K. Gruenkemeyer, E. Wood, A. Beck, C. Belsha

    Pediatric Nephrology, Saint Louis University, Saint Louis, MO

    *Purpose: BK viremia is an important problem in the pediatric renal transplant population leading to increased risk for viral associated nephropathy in the transplant. Early…
  • 2019 American Transplant Congress

    Extracellular Vesicles (EV) Mediate Antibody-Independent Tubular Senescence via Cyclin-Dependent Kinase Inhibitors p21/p16 in Antibody-Mediated Rejection (AMR)

    C. Divella1, A. Stasi1, R. Franzin1, F. Sallustio2, C. Curci1, G. Merlotti3, M. Quaglia3, L. Gesualdo1, V. Cantaluppi1, G. Castellano1

    1Emergency and Organ Transplantation, University of Bari, Bari, Italy, 2Emergency and Organ Transplantation / Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy, 3Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy

    *Purpose: Recent data suggest a strong correlation between kidney injury and the occurrence of accelerated senescence process, known as “Inflammaging”. However, the role of TEC…
  • 2019 American Transplant Congress

    Alloreactive B Cells in Transplant Tolerant Recipients Cannot Differentiate into Antibody-Secreting Cells but Can Suppress Donor-Specific IgG Production By Naïve B Cells

    S. H. Khiew1, J. Chen1, D. Jain1, Q. Wang1, D. Yin1, M. Alegre2, A. S. Chong1

    1Department of Surgery, Section of Transplant, University of Chicago, Chicago, IL, 2Department of Medicine, University of Chicago, Chicago, IL

    *Purpose: Donor specific transplantation tolerance has long been the goal of clinical transplantation. Clinical observations suggest that donor-specific antibodies (DSA) are a major cause of…
  • 2019 American Transplant Congress

    B Cell Immunophenotypes in Transplantation

    M. Cascalho1, M. de Mattos-Barbosa2, E. A. Farkash3, J. L. Platt2

    1University of Michigan, Ann Arbor, MI, 2Surgery, University of Michigan, Ann Arbor, MI, 3Pathology, University of Michigan, Ann Arbor, MI

    *Purpose: B cells and B cell responses have been associated with favorable outcomes of transplantation in some setting and unfavorable outcomes in others. For example,…
  • 2019 American Transplant Congress

    Next Gen ABO Antibody Assessment: Development of a Bead-Based ABO Antibody Detection Assay

    A. Halpin1, J. Pearcey2, B. Motyka2, S. Maier2, J. Zhou3, T. L. Lowary4, C. W. Cairo4, L. J. West1

    1Dept of Pediatrics, Dept of Laboratory Medicine, GlycoNet, ATI, CDTRP, University of Alberta, Edmonton, AB, Canada, 2Dept of Pediatrics, ATI, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada, 3Dept of Laboratory Medicine, University of Alberta, Edmonton, AB, Canada, 4Dept of Chemistry, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada

    *Purpose: Accurate characterization of ABO antibodies (ABO-Ab) is critical to assess their impact in ABO incompatible (ABOi) transplantation. The current ABO-Ab detection method using erythrocyte…
  • 2019 American Transplant Congress

    Clazakizumab (CLZ, Anti-IL-6 Monoclonal Antibody) Treatment of Patients (Pts) with Chronic Antibody-Mediated Rejection (cABMR) Reduces Total Immunoglobulin (Ig) and Anti-HLA IgG Antibody Levels

    B. Shin, N. F. Ammerman, A. A. Vo, X. Zhang, S. C. Jordan, M. Toyoda

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: We have recently reported successful use of Tocilizumab (TCZ), an anti-IL-6 receptor (R) monoclonal antibody, for cABMR treatment in HLA-sensitized kidney transplant (KTx) Pts.…
  • 2019 American Transplant Congress

    Desensitization Using Only IVIG: Is That an Option for Highly-Sensitized Patients Waiting for Kidneys from Cadaveric Donors?

    J. O. Paixão, L. R. Ulisses, P. S. Souza, G. Bezerra, F. Agena, H. P. Rodrgues, N. Panajotopoulos, F. J. Paula, E. David-Neto, M. R. Castro

    Nefrologia, Hospital das Clínicas da Universidade de São Paulo, São Paulo, Brazil

    *Purpose: The reduction of anti-HLA has been proven to be efficient and safe in transplants of highly-sensitized with living donors (LD). The results of adopting…
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