ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunogenicity"

  • 2019 American Transplant Congress

    The Response to Human Papillomavirus Vaccination in Pediatric Patients before and after Kidney Transplantation

    C. Nailescu1, R. D. Nelson2, K. Twombley3, P. S. Verghese4, A. S. Chishti5, M. Mills6, J. E. Slaven7, J. D. Mahan8, M. L. Shew1

    1Riley Hospital for Children, Indianapolis, IN, 2Primary Children’s Hospital, Salt Lake City, UT, 3MUSC Children’s Hospital, Charleston, SC, 4Children’s Hospitals and Clinics of Minnesota, Minneapolis, MN, 5Kentucky Children’s Hospital, Lexington, KY, 6C.S. Mott Children’s Hospital, Ann Arbor, MI, 7Indiana University, Indianapolis, IN, 8Nationwide Children’s Hospital, Columbus, OH

    *Purpose: Kidney transplant (KT) recipients have an increased incidence of malignancies, including Human Papillomavirus (HPV)-associated cancers. Thus, HPV vaccines may have an important role in…
  • 2019 American Transplant Congress

    Kidney Allografts Induce Systemic Tolerance of Heart Allografts and is Dependent on Foxp3+ Cells

    C. Yang1, J. Ge1, P. S. Russell1, J. C. Madsen1, A. Alessandrini1, R. B. Colvin2

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Pathology, Massachusetts General Hospital, Boston, MA

    *Purpose: We have successfully achieved cardiac allograft tolerance in both pigs and NHP by donor kidney co-transplantation. The mechanism of Kidney Induced Cardiac Allograft Tolerance…
  • 2019 American Transplant Congress

    Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates

    H. Sweiss1, J. Lyons1, D. Ranch2, K. Hitchman2, E. Kincaide1, B. Crowther1

    1University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 2University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX

    *Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…
  • 2019 American Transplant Congress

    Mismatched Epitope and De Novo DSA Development: An Analysis of the Benefit and Benefit-EXT Renal Transplant Cohorts

    V. Jucaud1, V. Burnett1, H. Gebel2, R. Bray2, M. Polinsky3, M. Everly1

    1Terasaki Research Institute, Los Angeles, CA, 2Emory University, Atlanta, GA, 3Bristol-Myers Squibb, Princeton, NJ

    *Purpose: De novo donor-specific HLA antibodies (dnDSA) target epitopes rather than whole antigens, and their development is associated with the mismatched HLA antibody epitope load…
  • 2019 American Transplant Congress

    Computational Assessment of T-cell and B-cell Allorecognition to Predict Donor HLA Immunogenicity

    H. C. Copley1, M. Elango1, V. Kosmoliaptsis2

    1Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital, Cambridge, United Kingdom, 2University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital & NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation at the University of Cambridge, Cambridge, UK., Cambridge, United Kingdom

    *Purpose: Donor-specific alloantibody (DSA) development after solid-organ transplantation is a major cause of graft loss, and limits future transplant options. We have previously shown that…
  • 2019 American Transplant Congress

    Physiochemical Hla Properties Identify Low Immunogenic Donor/recipient Pairs Predicting Long-term Kidney Graft Survivals

    D. Bekbolsynov1, B. Mierzejewska2, C. Ho1, M. Rees2, S. Stepkowski2

    1Gift of Life Michigan, Ann Arbor, MI, 2University of Toledo, Toledo, OH

    *Purpose: Although it is well-recognized that HLA matching improves the long-term kidney graft survival, less than 10% of transplants are currently HLA matched. We measured…
  • 2019 American Transplant Congress

    A Comparison of Cell-Mediated Immune Responses among Organ Transplant Recipients Receiving High-Dose vs Standard-Dose Influenza Vaccine

    A. G. L'Huillier, V. H. Ferreira, Y. Natori, T. Ku, C. Hirzel, M. Ierullo, A. Humar, D. Kumar

    University Health Network, Toronto, ON, Canada

    *Purpose: The High-dose (HD) influenza vaccine has been shown to induce better humoral immunity than the standard-dose (SD) vaccine in solid organ transplant (SOT) patients.…
  • 2019 American Transplant Congress

    Utilizing Ides To Eliminate Residual Antibodies Targeting Xenografts

    C. Rickert, K. Lee, N. Tanimine, J. Lei, A. Cuenca, N. Feeney, K. Deng, H. Yeh, J. F. Markmann

    Massachusetts General Hospital, Boston, MA

    *Purpose: A significant hinderance to the successful use of xenotransplantation has been the presence of preformed antibodies against the donor antigens, known as xenoantigens. Using…
  • 2019 American Transplant Congress

    Analysis of Immune Cell Proportions in Kidney Transplant Biopsies of Acute Cellular Rejection and Antibody Mediated Rejection Compared with Non-Rejecters

    C. R. Dorr1, A. Muthusamy1, D. P. Schladt1, W. Guan2, B. Wu2, J. S. Maltzman3, W. S. Oetting2, P. A. Jacobson2, A. K. Israni1

    1Hennepin Healthcare Research Institute, Minneapolis, MN, 2University of Minnesota, Minneapolis, MN, 3Stanford University, Palo Alto, CA

    *Purpose: Understanding the immune cell types that are associated with acute rejection (AR) in kidney transplant biopsies may lead to new therapeutic targets for AR.…
  • 2019 American Transplant Congress

    In Vitro Model to Study the Effect of Irradiation Preconditioning on Alloimmune Responses: Development of Potential Predictive Markers

    K. Shimozawa, K. Janec, L. Contreras-Ruiz, E. C. Guinan

    Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA

    *Purpose: Pre-conditioning using total body irradiation prior to HSCT is a well-established regimen for patients with hematological malignancy. However, irradiation (IR) elicits not only immunosuppressive…
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