2019 American Transplant Congress
Utilizing Ides To Eliminate Residual Antibodies Targeting Xenografts
Massachusetts General Hospital, Boston, MA
*Purpose: A significant hinderance to the successful use of xenotransplantation has been the presence of preformed antibodies against the donor antigens, known as xenoantigens. Using…2019 American Transplant Congress
Analysis of Immune Cell Proportions in Kidney Transplant Biopsies of Acute Cellular Rejection and Antibody Mediated Rejection Compared with Non-Rejecters
*Purpose: Understanding the immune cell types that are associated with acute rejection (AR) in kidney transplant biopsies may lead to new therapeutic targets for AR.…2019 American Transplant Congress
In Vitro Model to Study the Effect of Irradiation Preconditioning on Alloimmune Responses: Development of Potential Predictive Markers
Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: Pre-conditioning using total body irradiation prior to HSCT is a well-established regimen for patients with hematological malignancy. However, irradiation (IR) elicits not only immunosuppressive…2019 American Transplant Congress
Islet Stress Leads to Increased Release of Exosomes That Stimulate Immune Cell Response
*Purpose: Islet dysfunction and death caused by isolation procedures, immune attack and hypoxia significantly affect islet transplantation outcomes. Non-invasive monitoring of islet stress and damage…2019 American Transplant Congress
Characterization of Intra-Exosomal Cargoes of Circulating Donor Heart Specific Exosomes in Murine Heart Transplantation Model
Department of Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Exosomes are tissue specific, bilayered, membrane-bound nanoparticles released by many types of cells into bodily fluids including blood and urine. Exosomes carry protein and…2019 American Transplant Congress
Impact Of Donor And Recipient Race On Kidney Transplant Survivals Evaluated By The Physiochemically-calculated Hla Immunogenicity
University of Toledo, Toledo, OH
*Purpose: Graft survivals are inferior for African American (AA) patients in comparison to Caucasian (CAU) patients in the United States. We examined how donor and…2019 American Transplant Congress
Report of 20 HLAMatchmaker Eplets Present on Denatured Class I HLA Molecules
*Purpose: The purpose of this report is to describe 20 class I HLA eplets, herein called FakEplets, present on denatured HLA molecules.*Methods: The study included…2019 American Transplant Congress
Endothelial Cells Do Not Regulate Expression of CD46, CD55 and CD59 in the Presence of Anti-HLA Class I and 11 Antibodies
*Purpose: Anti-HLA antibodies, both pre-formed and de novo are associated with worse graft survival. Complement activation is an important mechanism of antibody mediated immunological injury.…2019 American Transplant Congress
The Response to Human Papillomavirus Vaccination in Pediatric Patients before and after Kidney Transplantation
*Purpose: Kidney transplant (KT) recipients have an increased incidence of malignancies, including Human Papillomavirus (HPV)-associated cancers. Thus, HPV vaccines may have an important role in…2019 American Transplant Congress
Kidney Allografts Induce Systemic Tolerance of Heart Allografts and is Dependent on Foxp3+ Cells
*Purpose: We have successfully achieved cardiac allograft tolerance in both pigs and NHP by donor kidney co-transplantation. The mechanism of Kidney Induced Cardiac Allograft Tolerance…
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