ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunogenicity"

  • 2018 American Transplant Congress

    Simultaneous Persistence and Development of Donor and Recipient Tissue Resident Memory T Cells in Lung Transplantation

    M. Snyder,1 T. Connors,2 C. Marboe,3 L. Benvenuto,1 L. Shah,1 H. Robbins,1 J. Hook,1 F. D'Ovidio,4 M. Bacchetta,4 J. Sonnett,4 S. Arcasoy,1 D. Farber.4,5

    1Medicine, Columbia University Medical Center, New York, NY; 2Pediatrics, Columbia University Medical Center, New York, NY; 3Pathology, Columbia University Medical Center, New York, NY; 4Surgery, Columbia University Medical Center, New York, NY; 5Microbiology & Immunology, Columbia University Medical Center, New York, NY.

    Introduction: The predominant T cell population in the lung comprises non-circulating tissue-resident memory T cells (TRM); however, the fate of these cells in transplanted lung…
  • 2018 American Transplant Congress

    Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses Acute Allograft Rejection and Prolongs Graft Survival in Murine Heart Transplantation

    T. Tanaka, T. Maehana, N. Masumori.

    Department of Urology, Sapporo Medical University, Sapporo, Japan.

    Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor to recipients prolonged the allograft survival in murine skin and…
  • 2018 American Transplant Congress

    Determining the Relative Immunogenicity of HLA Mismatches with Calcineurin Inhibitor Immunosuppression: An Analysis of the BENEFIT and BENEFIT-EXT Renal Transplant Cohort

    V. Jucaud,1 M. Roberts,2 H. Gebel,3 R. Bray,3 M. Everly.1

    1Terasaki Research Institute, Los Angeles, CA; 2Immunology Biomarker Group, Bristol-Myers Squibb, Princeton, NJ; 3Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.

    We studied the relative immunogenicity of HLA-A, -B, -C, -DR and -DQ MM (serological) in a cohort of 291 kidney transplant patients from the BENEFIT…
  • 2018 American Transplant Congress

    Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immune Regulatory Proteins in Lung Transplant Recipient with Primary Graft Dysfunction

    M. Sharma, S. Biswas Roy, R. Walia, A. Omar, R. Bremner, M. Smith, T. Mohanakumar.

    Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.

    Background: Circulating exosomes isolated from lung transplant recipients (LTxRs) with acute or chronic rejection contains lung self-antigens (SAgs), K alpha 1 tubulin (Kα1T) and collagen…
  • 2018 American Transplant Congress

    Antibody-Verified Eplet Mismatches as Determinants of Premature Kidney Transplant Loss

    R. Sapir-Pichhadze,1 X. Zhang,1 A. Ferradji,1 A. Madbouly,2 S. Fingerson,2 K. Tinckam,5 H. Gebel,3 H. Cardinal,4 B. Foster.1

    1McGill University, Montreal, Canada; 2National Marrow Donor Program, Minneapolis; 3Emory University Hospital, Atlanta; 4CHUM, Montreal, Canada; 5University Health Network, Toronto, Canada.

    Introduction: HLA matching at the epitope level offers new opportunities to identify compatible donors for transplant candidates. HLAMatchmaker deduces B-cell epitope ('eplets' in HLAMatchmaker) mismatches…
  • 2018 American Transplant Congress

    Novel Function of TIE2 in Immunoregulation

    C. Ghosh, T. Agur, A-.L. Mak, S. Pal, J. Wedel, B. David.

    Transplant Research Program, Boston Children's Hospital, Boston, MA.

    The immunogenicity of graft microvascular endothelial cells (ECs) has immense biological significance in the modulation of the local intragraft microenvironment. EC may either support Teffector…
  • 2018 American Transplant Congress

    Rapamycin Impairs Human Endothelial Cell Alloimmunogenicity Independent of PD-1/PD-1 Ligand Inhibitory Signaling

    Q. Gao, V. Bendersky, A. Kirk, H. Xu.

    Department of Surgery, Duke University Medical Center, Durham, NC.

    Rapamycin prevents costimulation blockade (CoB)-resistant rejection in mice and primates, and early human data suggests a similar salutary effect. We have hypothesized that one mechanism…
  • 2018 American Transplant Congress

    Genome Wide Non-HLA Alloimmunity Contributes to Graft Loss after Kidney Transplantation

    R. Reindl-Schwaighofer, A. Heinzel, A. Kainz, K. Jelencsics, O. Viklicky, G. Böhmig, G. Fischer, B. Keating, R. Oberbauer.

    Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Transplant Institute, University of Pennsylvania, Philadelphia, PA.

    BackgroundChronic rejection is the main cause of renal transplant loss after the first year and has mostly been attributed to alloimmune responses against human leukocyte…
  • 2017 American Transplant Congress

    Impact of Belatacept Conversion on Kidney Transplant Function, Histology and Gene Expression.

    P. Sanghi,1 G. Gupta,1 D. Kumar,1 J. Reeve,2 M. Levy,1 A. Sharma,1 H. Fattah,1 P. Kimball,1 H. Massey,1 A. King,1 P. Halloran.2

    1Virginia Commonwealth University, Richmond; 2Alberta Transplant Applied Genomics Center, Edmonton, Canada

    Background: Belatacept (bela) might be an alternative to Calcineurin Inhibitors (CNI) in order to avoid presumed nephrotoxicity. In this study we assessed the impact of…
  • 2017 American Transplant Congress

    Liver Mesenchymal Stem Cells Inhibit T Cell Alloresponses.

    T. Taner, M. Gustafson, M. Hansen, A. Dietz, M. Stegall.

    Mayo Clinic, Rochester, MN

    Clinical and histologic evidence suggest that the liver allograft induces alloimmune hyporesponsiveness in the recipient. Mesenchymal stem cells (MSC) are multipotent non-hematopoietic stromal cells with…
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