2020 American Transplant Congress
HLA Mismatch Immunogenicity: Are We Predicating Mismatches That Induce De Novo DSA Development or That Do Not?
*Purpose: Although the development of de novo donor-specific anti-HLA antibodies (dnDSA) remains a major risk factor for poor long-term kidney allograft outcomes, the prediction of…2020 American Transplant Congress
The Impact of HLA-DQ Molecular Mismatches on De Novo Occurrence of Donor-Specific Anti-HLA Antibodies after Kidney Transplantation: An Observational Cohort Study
*Purpose: Evaluating HLA molecular mismatches (MM) instead of antigen mismatches might be a better tool to assess donor-recipient HLA incompatibility and provide a better risk…2020 American Transplant Congress
Relapse-Prone Unresectable Hepatoblastoma (HB) Requiring Liver Transplantation (LT) Are Immunogenic and May Be Sensitive to Immune Checkpoint Inhibitors
1Pediatric Transplant, Pittsburgh, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Unresectable HB accounts for 8% of all pediatric LT. Post-LT relapse rates approach 20% indicating a need for more effective neoadjuvant chemotherapy.*Methods: To discover…2020 American Transplant Congress
A Simple HLA Class II Matching Strategy for the Prediction of De Novo Donor-Specific HLA Antibodies
*Purpose: In kidney transplantation, degree of HLA Class II mismatch (MM) between donor and recipient drives the risk to develop de novo DSA (dnDSA). New…2020 American Transplant Congress
Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver
*Purpose: Transplantation is the best treatment option for end-stage liver failure. There remains a critical need to develop targeted therapeutic strategies to decrease graft rejection…2020 American Transplant Congress
High Frequencies of Donor-Derived Memory T and NK Cells in the Blood of Lung Transplant Recipients May Contribute to Protection from Chronic Lung Allograft Dysfunction
*Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…2020 American Transplant Congress
Role of Circulating Exosomes in the Induction of Immune Responses Resulting in Cardiac Allograft Rejection in miR155 Knockout Animals
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Our goal is to define the mechanism by which circulating exosomes with cardiac self-antigens (SAgs), Myosin, Vimentin, and angiotensin Receptor 1 Protein (AGTR1) leads…2020 American Transplant Congress
Low Physiochemical Immunogenicity Scores Improve Long-Term Survival of Deceased Donor Kidney Transplants
*Purpose: A severe shortage of deceased donor kidneys limits access to kidney transplantation. Limited longterm graft function exacerbates this shortage as 12% of the waiting…2020 American Transplant Congress
Contrary to Expectation, the Use of Immune Checkpoint Inhibitors is Not Consistently Associated with Early Onset Allograft Rejection in Solid Organ Transplant Recipients
*Purpose: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but are generally avoided in solid organ transplant recipients (SOTRs) due to concern for allograft rejection…2020 American Transplant Congress
Role of B-Cell Subsets in Allograft Rejection in Intestinal Transplantation
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: While B-cells contribute to allograft rejection by presenting antigens to T-cells and by producing donor-specific antibodies (DSAs) and various cytokines, their pathophysiology in transplant…
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