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Articles tagged "Immunogenicity"

  • 2022 American Transplant Congress

    Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation

    S. Vasu1, C. Darden2, J. Mattke2, Y. Liu3, M. C. Lawrence3, B. Naziruddin1

    1Baylor University Medical Ctr, Dallas, TX, 2Baylor University, Waco, TX, 3Baylor University Medical Center, Dallas, TX

    *Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…
  • 2022 American Transplant Congress

    Impaired Cellular Immunity and Elevated Myeloid Derived Suppressor Cells in Kidney Transplant Recipients with Impaired Antibody Response to Covid-19 Vaccination

    B. Nibhanupudy1, K. Mcdonald1, M. Angelis1, L. T. Chin1, P. Wai1, R. Metzger1, C. Ashokkumar2, R. Sindhi2

    1AdventHealth Transplant Institute, Orlando, FL, 2Plexision, Inc, Pittsburgh, PA

    *Purpose: To evaluate post-vaccination cellular and antibody (Ab) immunity after COVID-19 vaccination in single blood samples from 17 kidney transplant (KT) recipients who had received…
  • 2022 American Transplant Congress

    Antibody Response and Cellular Phenotyping in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination

    N. M. Ali1, J. Miles2, S. Mehta1, V. Tatapudi1, B. Lonze1, E. Weldon1, Z. Stewart1, C. DiMaggio1, J. Allen3, S. Gray-Gaillard3, S. Solis3, M. Tuen3, J. Leonard1, R. Montgomery1, R. Herati3

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, NY, 3NYU Langone Health, New York, NY

    *Purpose: Correlates of protection for SARS-CoV-2 vaccines are not well-established in kidney transplant recipients(KTRs). Studies have highlighted the importance of neutralizing antibodies(Abs), however data suggests…
  • 2022 American Transplant Congress

    Safety and Immunogenicity of Live Viral Vaccination After Pediatric Liver and Kidney Transplantation

    A. Feldman1, B. Beaty1, N. Ebel2, J. Ferrolino3, V. Gopalareddy4, J. Hollenbeck5, C. Jaramillo6, N. Kerkar7, S. Lerret8, G. Maron3, A. Mavis9, N. Ovchinsky10, M. Sell11, T. Sharma12, J. Stoll13, L. Danziger-Isakov14

    1UCD, Aurora, CO, 2Stanford, Palo Alto, CA, 3St. Jude, Memphis, TN, 4LCH, Charlotte, NC, 5Michigan Medicine, Ann Arbor, MI, 6PCH, Salt Lake City, UT, 7URMC, Rochester, NY, 8MCW, Milwaukee, WI, 9Duke, Durham, NC, 10Montefiore, NYC, NY, 11MUSC, Charleston, SC, 12BCH, Boston, MA, 13WUSM, St Louis, MO, 14CCHMC, Cincinnati, OH

    *Purpose: New recommendations suggest that measles-mumps-rubella vaccine (MMR-vx) and varicella vaccine (VZV-vx) may be administered to certain non-immune transplant recipients. The purpose of this study…
  • 2022 American Transplant Congress

    Single Blind Randomized Controlled Trial Comparing BNT162b2 Vs JNJ-78436735 Vaccine As An Additional Dose After Two Doses Of BNT162b2 Vaccine In Solid Organ Transplant (SOT) Recipients

    Y. Natori1, E. Martin2, A. Mattiazzi3, J. Bini Viotti1, K. S. Ortecho4, S. Pallikkuth5, S. Anjan1, J. Simkins1, G. Guerra3

    1Department of Medicine, Division of Infectious Diseases, University of Miami, Miami, FL, 2Department of Medicine, Division of Hepatology, University of Miami, Miami, FL, 3Department of Medicine, Division of Nephrology, University of Miami, Miami, FL, 4Miami Transplant Institute, Jackson Health System, Miami, FL, 5University of Miami, Miami, FL

    *Purpose: Even though a high efficacy and immunogenicity of COVID-19 vaccines have been reported in the general population, vaccine immunogenicity is suboptimal in SOT recipients…
  • 2022 American Transplant Congress

    Molecular Characterization of the Plasma Secretome in Pediatric Liver Transplantation (pLTx) Identified Cytokine/Chemokine Signatures Potentially Linked to Beneficial Immunosuppressive Regimes (IS) and Recovery

    E. Chichelnitskiy1, L. Ruhl2, I. Goldschmidt3, A. Karch4, L. Antiga5, D. Debray6, L. Hierro7, D. Kelly8, V. McLin9, E. Nicastro10, J. Pawlowska11, P. Czubkowski11, R. Mikolajczyk12, U. Baumann13, C. Falk14

    1Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, 2Institute of Transplant Immunology, MHH, Hannover, Germany, 3Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, 4Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover;Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, 5Ospedali Riuniti di Bergamo, Bergamo, Italy, 6Hôpital Necker-Enfants Malades, Paris, France, 7Hospital Infantil Universitario La Paz, Madrid, Spain, 8Birmingham Childrens Hosp, Birmingham, United Kingdom, 9Service Spécialités Pédiatriques, Genève, Switzerland, 10Pediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy, 11Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, 12Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle; German Center for Infection Research, TTU-IICH Hannover; MHH, Halle, Germany, 13Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK, Hannover, Germany, 14Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany

    *Purpose: In the European multicentre “ChilSFree” study we aimed to characterize longitudinal dynamics of soluble immune mediators during the first year after pLTx.*Methods: Using Luminex-based…
  • 2021 American Transplant Congress

    An HLA Class II Matching Strategy That Predicts De Novo Donor-specific HLA Antibody Formation Using Low Resolution HLA Types

    L. Hidalgo1, I. Martinez Juarez2, L. Morales Buenrostro2, S. Shojai3, P. Campbell1

    1University of Wisconsin Madison, Madison, WI, 2Instituto Nacional de Ciencias Medicas Y Nutricion Salvador Zubrian, Mexico City, Mexico, 3Medicine, University of Alberta, Edmonton, AB, Canada

    *Purpose: The development of de novo donor-specific HLA antibodies (dnDSA) is predominantly against HLA-Class II antigens and is a function of the degree of HLA-DQ…
  • 2021 American Transplant Congress

    Limited Immunogenicity of a Single Dose of Sars-cov-2 Mrna Vaccine in Solid Organ Transplant Recipients

    B. Boyarsky, M. Ou, R. Greenberg, A. Teles, W. Werbel, R. Avery, A. Tobian, A. Massie, D. Segev, J. Garonzik Wang

    Johns Hopkins, Baltimore, MD

    *Purpose: Given substantial challenges with vaccine allocation and evidence for short-term vaccine efficacy after a single dose of SARS-CoV-2 mRNA vaccines in clinical trials, some…
  • 2021 American Transplant Congress

    Precision Medicine in Renal Transplantation: Structural Biology of HLA Defines Allelic Binding of Cardinal Pathogenic Viruses in Transplantation

    K. R. Sherwood1, A. Nguyen2, J. Tran1, O. Gunther3, A. Nellore2, R. Thompson2, J. Lan1, L. Allan1, P. A. Keown1

    1Vancouver General Hospital, Vancouver, BC, Canada, 2Biomedical Engineering, Oregon Health & Science University, Portland, OR, 3Gunther Analytics, Vancouver, BC, Canada

    *Purpose: The incidence, clearance and clinical expression of viremia post-Tx are heterogeneous, complicating prediction, prognosis and therapy. We postulated that variation viral presentation related to…
  • 2021 American Transplant Congress

    HLA I Antibody-Activated Endothelium Polarized M2-Like Macrophages with Increased Efferocytic and Phagocytic Capacity

    J. Nevarez-Mejia1, X. Wei1, N. M. Valenzuela1, M. Rossetti1, H. Pickering1, G. A. Fishbein1, A. Mulder2, E. F. Reed1

    1Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 2Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands

    *Purpose: The role of intragraft macrophages (Mϕs) during antibody-mediated rejection (AMR) remains unclear. Anti-HLA Abs during AMR drives vascular inflammation as seen by monocyte recruitment…
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