Articles tagged "Image analysis"

2020 American Transplant Congress
Hyperspectral Imaging of Human Kidney Allografts
R. Sucher¹, H. Köhler², A. Lederer¹, H. M. Hau¹, I. Gockel¹, D. Seehofer¹
¹Department of Visceral, Transplant-, Thoracic and Vascular Surgery, University Clinic Leipzig, Leipzig, Germany, ²Innovation Center for Computer Assisted Surgery, University Clinic Leipzig, Leipzig, Germany
*Purpose: Hyperspectral imaging (HSI) is capable to deliver non-contact, non-ionizing and non-invasive quantitative diagnostic information about tissue pathology, morphology and composition, based on the spectral…
2020 American Transplant Congress
Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation
A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall
Mayo Clinic, Rochester, Rochester, MN
*Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
2020 American Transplant Congress
Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?
C. M. Edwards¹, J. T. Langford¹, M. Reschke², J. R. DiRito¹, D. Mulligan¹, D. Haakinson¹, G. T. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale University, New Haven, CT
*Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
2020 American Transplant Congress
Computer-Assisted Cardiac Histologic Evaluation (CACHE) for Grading Cardiac Allograft Rejection
E. Peyster¹, S. ArabYarmohommadi², A. Janowczyk², M. Sekulic³, C. Cassol⁴, M. Feldman¹, K. Margulies¹, A. Madabhushi²
¹University of Pennsylvania, Philadelphia, PA, ²Case Western Reserve University, Cleveland, OH, ³University Hospitals Cleveland Medical Center, Cleveland, OH, ⁴Ohio State University, Columbus, OH
*Purpose: Cardiac allograft rejection (CAR) is a serious concern in heart transplantation, occurring in 30-40% of patients during the first year. Endomyocardial biopsy (EMB) with…
2020 American Transplant Congress
Noninvasive Imaging of CD122+ T Cells via Immuno-PET for Detection of Acute Cellular Rejection
A. J. Matar¹, B. P. Lovasik¹, D. Vanover², L. Rotolo², Y. Dong¹, D. A. Faber¹, D. V. Mathews¹, W. H. Kitchens¹, P. Santangelo², A. B. Adams¹
¹Surgery and Transplantation, Emory University, Atlanta, GA, ²Biomedical Engineering, Georgia Tech, Atlanta, GA
*Purpose: Acute cellular rejection (ACR) remains a clinically important problem following organ transplantation. Clinically, suspicion of ACR is dependent upon serum laboratory values, and diagnosis…
2020 American Transplant Congress
Imaging OX40+Alloreactive T Cells Provides Early Warning of Organ Transplant Rejection
T. Hirai¹, A. Mayer², T. W. Nobashi², Z. Xiao², T. Udagawa³, K. Seo⁴, F. Simonetta⁵, J. Baker⁵, A. Cheng³, S. S. Gambhir², R. S. Negrin⁵
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Radiology, Stanford University, Stanford, CA, ³Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, ⁴Division of Cardiovascular Medicine, Stanford University, Stanford, CA, ⁵Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA
*Purpose: Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immuno positron emission tomography (immunoPET) utilizing…
2020 American Transplant Congress
Multiplexed Imaging Mass Cytometry Analysis Reveals a New Role for CD68+ Macrophages in Chronic Liver Transplant Rejection
J. Emamaullee, C. Man, J. Hoeflich, N. Ung, R. Sun, N. Matasci, J. Katz, J. Lee, S. Chopra, L. Sher, S. Asgharzadeh, O. Akbari, Y. Genyk
University of Southern California, Los Angeles, CA
*Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Recently, a novel high-resolution mass spectrometry-based technique has been…
2020 American Transplant Congress
High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome
Y. Liu, K. Kumano, S. Vasu, C. M. Darden, M. Lawrence, B. Naziruddin
Baylor University Medical Ctr, Dallas, TX
*Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…
2020 American Transplant Congress
Deep Learning for Living Donor Surgery: AI Recognition of Surgical Video to Develop Navigation Systems for Laparoscopic Nephrectomy
M. Nishihara¹, K. Iwadoh², M. Noriyuki¹, I. Koyama², I. Nakajima², M. Tonsho¹
¹Transplant Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan, ²Kidney Surgery, Tokyo Women's Medical University Hospital, Tokyo, Japan
*Purpose: Laparoscopic surgery for living donors requires high safety, thus establishing of navigation system for surgical operation is urged. The purpose of this study was…
2020 American Transplant Congress
Prognostic Impact of Peritumoral Neutrophil Infiltration on Hepatocellular Carcinoma Recurrence Following Liver Transplantation
M. Najjar¹, K. Halazun², M. Mondal¹, A. Srivastava¹, M. Moore¹, E. Rizk¹, R. Gartrell¹, H. Remotti¹, L. Fazlollahi¹, E. Verna¹, A. Griesemer¹, A. Mathur¹, B. Samstein², J. Emond¹, Y. Saenger¹
¹Columbia University Irving Medical Center, New York, NY, ²Weill Cornell Medicine, New York, NY
*Purpose: Peritumoral neutrophil (PMN) infiltration has been associated with poor clinical outcomes in various tumors; however, its role in hepatocellular carcinoma (HCC) remains understudied. Moreover,…