ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Image analysis"

  • 2020 American Transplant Congress

    Hyperspectral Imaging of Human Kidney Allografts

    R. Sucher1, H. Köhler2, A. Lederer1, H. M. Hau1, I. Gockel1, D. Seehofer1

    1Department of Visceral, Transplant-, Thoracic and Vascular Surgery, University Clinic Leipzig, Leipzig, Germany, 2Innovation Center for Computer Assisted Surgery, University Clinic Leipzig, Leipzig, Germany

    *Purpose: Hyperspectral imaging (HSI) is capable to deliver non-contact, non-ionizing and non-invasive quantitative diagnostic information about tissue pathology, morphology and composition, based on the spectral…
  • 2020 American Transplant Congress

    Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation

    A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall

    Mayo Clinic, Rochester, Rochester, MN

    *Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
  • 2020 American Transplant Congress

    Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?

    C. M. Edwards1, J. T. Langford1, M. Reschke2, J. R. DiRito1, D. Mulligan1, D. Haakinson1, G. T. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale University, New Haven, CT

    *Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
  • 2020 American Transplant Congress

    Computer-Assisted Cardiac Histologic Evaluation (CACHE) for Grading Cardiac Allograft Rejection

    E. Peyster1, S. ArabYarmohommadi2, A. Janowczyk2, M. Sekulic3, C. Cassol4, M. Feldman1, K. Margulies1, A. Madabhushi2

    1University of Pennsylvania, Philadelphia, PA, 2Case Western Reserve University, Cleveland, OH, 3University Hospitals Cleveland Medical Center, Cleveland, OH, 4Ohio State University, Columbus, OH

    *Purpose: Cardiac allograft rejection (CAR) is a serious concern in heart transplantation, occurring in 30-40% of patients during the first year. Endomyocardial biopsy (EMB) with…
  • 2020 American Transplant Congress

    Noninvasive Imaging of CD122+ T Cells via Immuno-PET for Detection of Acute Cellular Rejection

    A. J. Matar1, B. P. Lovasik1, D. Vanover2, L. Rotolo2, Y. Dong1, D. A. Faber1, D. V. Mathews1, W. H. Kitchens1, P. Santangelo2, A. B. Adams1

    1Surgery and Transplantation, Emory University, Atlanta, GA, 2Biomedical Engineering, Georgia Tech, Atlanta, GA

    *Purpose: Acute cellular rejection (ACR) remains a clinically important problem following organ transplantation. Clinically, suspicion of ACR is dependent upon serum laboratory values, and diagnosis…
  • 2020 American Transplant Congress

    Imaging OX40+Alloreactive T Cells Provides Early Warning of Organ Transplant Rejection

    T. Hirai1, A. Mayer2, T. W. Nobashi2, Z. Xiao2, T. Udagawa3, K. Seo4, F. Simonetta5, J. Baker5, A. Cheng3, S. S. Gambhir2, R. S. Negrin5

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Department of Radiology, Stanford University, Stanford, CA, 3Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, 4Division of Cardiovascular Medicine, Stanford University, Stanford, CA, 5Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA

    *Purpose: Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immuno positron emission tomography (immunoPET) utilizing…
  • 2020 American Transplant Congress

    Multiplexed Imaging Mass Cytometry Analysis Reveals a New Role for CD68+ Macrophages in Chronic Liver Transplant Rejection

    J. Emamaullee, C. Man, J. Hoeflich, N. Ung, R. Sun, N. Matasci, J. Katz, J. Lee, S. Chopra, L. Sher, S. Asgharzadeh, O. Akbari, Y. Genyk

    University of Southern California, Los Angeles, CA

    *Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Recently, a novel high-resolution mass spectrometry-based technique has been…
  • 2020 American Transplant Congress

    High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome

    Y. Liu, K. Kumano, S. Vasu, C. M. Darden, M. Lawrence, B. Naziruddin

    Baylor University Medical Ctr, Dallas, TX

    *Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…
  • 2020 American Transplant Congress

    Deep Learning for Living Donor Surgery: AI Recognition of Surgical Video to Develop Navigation Systems for Laparoscopic Nephrectomy

    M. Nishihara1, K. Iwadoh2, M. Noriyuki1, I. Koyama2, I. Nakajima2, M. Tonsho1

    1Transplant Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan, 2Kidney Surgery, Tokyo Women's Medical University Hospital, Tokyo, Japan

    *Purpose: Laparoscopic surgery for living donors requires high safety, thus establishing of navigation system for surgical operation is urged. The purpose of this study was…
  • 2020 American Transplant Congress

    Prognostic Impact of Peritumoral Neutrophil Infiltration on Hepatocellular Carcinoma Recurrence Following Liver Transplantation

    M. Najjar1, K. Halazun2, M. Mondal1, A. Srivastava1, M. Moore1, E. Rizk1, R. Gartrell1, H. Remotti1, L. Fazlollahi1, E. Verna1, A. Griesemer1, A. Mathur1, B. Samstein2, J. Emond1, Y. Saenger1

    1Columbia University Irving Medical Center, New York, NY, 2Weill Cornell Medicine, New York, NY

    *Purpose: Peritumoral neutrophil (PMN) infiltration has been associated with poor clinical outcomes in various tumors; however, its role in hepatocellular carcinoma (HCC) remains understudied. Moreover,…
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