2021 American Transplant Congress
Dissecting the Intrarenal Immune Response to Viral Infected Cells in Pediatric BK Virus-associated Nephropathy (BKVAN)
*Purpose: BKVAN is not only a cause of acute renal allograft injury but is a recognized cause of chronic allograft disease and in some patients,…2021 American Transplant Congress
Indocyanine Green Fluorescence Imaging Allows Quantification of Ischemic Injury During Porcine Normothermic Ex Situ Perfusion
Ajmera Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Situ Liver Perfusion (NEsLP) is a novel preservation technique for the storage and assessment of grafts retrieved after Donation after Cardio-circulatory Death…2021 American Transplant Congress
Novel Morphologic Biomarkers of Cardiac Allograft Remodeling are Associated with Multiple Peri- and Post-transplant Inflammatory Processes
*Purpose: It has long been recognized that transplanted hearts develop a stiffened, restrictive physiology at an accelerated rate compared to native hearts. While this is…2021 American Transplant Congress
The Tumor-suppressor Signaling of the α1-na/k-atpase- Cav-1-src Complex at the Caveola in Nash Related Hepatocellular Carcinoma
*Purpose: Hepatocellular Carcinoma (HCC) is the 2nd and fastest-growing cause of cancer related mortality worldwide, mainly from the metabolic cellular disturbances promoted by the epidemic…2021 American Transplant Congress
Patterns and Inhibition of Cell Death During Static Cold Storage of Human Kidneys
*Purpose: As the donor population continues to age and accumulate co-morbidities, more marginal kidneys are being retrieved for transplantation. However, estimates suggest that more than…2021 American Transplant Congress
The Microenvironment of Belatacept-Resistant Rejection
Surgery, Emory University, Atlanta, GA
*Purpose: Belatacept is a co-stimulation blockade immunosuppressant, that despite demonstrating improved long-term outcomes, has not been widely adopted, in part, due to concern over early…2021 American Transplant Congress
Multiplexed Imaging Mass Cytometry of the Alloimmune Landscape of Rejection in Clinical Liver Transplantation
University of Southern California, Los Angeles, CA
*Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Imaging Mass Cytometry (IMC) is an emerging preclinical technique…2021 American Transplant Congress
Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model
*Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…2020 American Transplant Congress
Hyperspectral Imaging of Human Kidney Allografts
*Purpose: Hyperspectral imaging (HSI) is capable to deliver non-contact, non-ionizing and non-invasive quantitative diagnostic information about tissue pathology, morphology and composition, based on the spectral…2020 American Transplant Congress
Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation
Mayo Clinic, Rochester, Rochester, MN
*Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
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