2022 American Transplant Congress
Human PBMC-Transferred Murine MHC Class I/II-Deficient NOG Mice Enable Long-Term Evaluation of Human Immune Responses to Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets
Center for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan
*Purpose: Transplantation of cardiomyocytes sheets derived from allogenic human induced pluripotent stem cells (hiPS-CMs) hold great promise in generating new functional myocardium in situ. However,…2022 American Transplant Congress
Pre-Transplant Ex-Vivo Analysis of Kidney Vasculature and Perfusion Using Contrast Computed Tomography
1Yale School of Medicine, New Haven, CT, 2University of Cambridge, Cambridge, United Kingdom
*Purpose: Ex-vivo normothermic perfusion (NMP) has been developed with the goal of improving viability of the thousands of donated organs that are declined for transplant…2022 American Transplant Congress
Use of Three-Dimensional (3D) Modeling Software for Preoperative Anatomical Assessment in Living Donor Nephrectomy
*Purpose: Successful and safe completion of living donor nephrectomy depends on donor anatomy. Preoperative imaging is imperative to determine operative feasibility and to avoid unexpected…2022 American Transplant Congress
Use of Three-Dimensional Volumetric Analysis to Monitor Acute Rejection in a Face Transplant Recipient
*Purpose: The purpose of this study is to determine the feasibility of using 3D facial stereography to monitor volume changes in a facial allograft, and…2022 American Transplant Congress
Smartphone-Microfluidic Fluorescence Imaging System for Studying Islet Physiology
University of Virginia, Charlottesville, VA
*Purpose: The goal of this study is to develop an innovative smartphone-microfluidic fluorescence imaging (µSFI) system for multi-parameter islet function characterization, which could provide quantitative…2021 American Transplant Congress
Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model
*Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…2021 American Transplant Congress
Multiplexed Imaging Mass Cytometry of the Alloimmune Landscape of Rejection in Clinical Liver Transplantation
University of Southern California, Los Angeles, CA
*Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Imaging Mass Cytometry (IMC) is an emerging preclinical technique…2021 American Transplant Congress
The Microenvironment of Belatacept-Resistant Rejection
Surgery, Emory University, Atlanta, GA
*Purpose: Belatacept is a co-stimulation blockade immunosuppressant, that despite demonstrating improved long-term outcomes, has not been widely adopted, in part, due to concern over early…2021 American Transplant Congress
Patterns and Inhibition of Cell Death During Static Cold Storage of Human Kidneys
*Purpose: As the donor population continues to age and accumulate co-morbidities, more marginal kidneys are being retrieved for transplantation. However, estimates suggest that more than…2021 American Transplant Congress
The Tumor-suppressor Signaling of the α1-na/k-atpase- Cav-1-src Complex at the Caveola in Nash Related Hepatocellular Carcinoma
*Purpose: Hepatocellular Carcinoma (HCC) is the 2nd and fastest-growing cause of cancer related mortality worldwide, mainly from the metabolic cellular disturbances promoted by the epidemic…
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