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Articles tagged "HLA antibodies"

  • 2015 American Transplant Congress

    Are DQA Antibodies Real?

    J. Jones, D. Lucas, M. Leffell, A. Zachary.

    Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

    Antibodies specific for HLA-DQ antigens appear to be increasing in frequency in the post-transplant period and are difficult to reduce effectively with desensitization protocols using…
  • 2015 American Transplant Congress

    Extended Analysis of Tocilizumab (anti-IL-6R) + Intravenous Immunoglobulin (IVIG) as Desensitization (DES) Agents for Reduction of Donor Specific Antibodies (DSA) in Patients Resistant to DES With IVIG + Rituximab

    A. Vo, J. Choi, I. Kim, J. Kahwaji, A. Peng, R. Villicana, S. Jordan.

    Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction: IVIG+rituximab is an acceptable approach for DES with good outcomes. Despite this, ∼30% of patients fail DES, thus other approaches are needed. Options include…
  • 2015 American Transplant Congress

    Incidence of De Novo Donor Specific Antibodies in Kidney Transplant Recipients

    C. Staino, N. Pilch, O. Moussa, K. Boyle, J. Casale, K. Covert, J. Fleming, D. Taber, H. Meadows, C. Mardis, K. Chavin, S. Nadig, J. McGillicuddy, C. Bratton, T. Srinivas, P. Baliga.

    MUSC, Charleston, SC.

    The reported incidence and risk factors for the development of de novo donor specific antibodies (dnDSA) are variable. Although dnDSA is a negative predictor of…
  • 2015 American Transplant Congress

    Differences in Reactivity of HLA-Specific Antibodies May Be Explained By Differences in Their Affinities for Selected Epitopes on HLA Proteins

    S. Daga,1,2 D. Lowe,6 R. Buchli,5 J. Collard,5 A. Mulder,8 C. McMurtrey,4,5 H. Moyse,7 N. Evans,7 N. Krishnan,2 W. Hildebrand,4,5 F. Claas,8 D. Briggs,3 D. Zehnder,1,2 D. Mitchell,1 R. Higgins.1,2

    1Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; 2Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; 3Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; 4University of Oklahoma Health Science Center, Oklahoma City; 5Pure Protein LLC, Oklahoma City; 6Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; 7School of Engineering, University of Warwick, Coventry, United Kingdom; 8Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.

    Affinity of IgG immunoglobulins for antigen varies and matures within the evolution of immune responses. Affinity is likely to be different for different epitope-antibody interactions…
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