Articles tagged "HLA antibodies"

2015 American Transplant Congress
The Effect of Preformed and De Novo Donor-Specific Antibodies (DSA) in Acute Rejection (AR) After Liver Transplantation (LTX)
M. Koch,¹ M. Runnebaum,¹ M. Goebel,² H. Thude,¹ M. Sterneck,¹ M. Marget,² B. Nashan.¹
¹Hepatobiliary Surgery and Transplantation, University Medical Centre, Hamburg, Germany; ²HLA-Laboratory, University Medical Centre, Hamburg, Germany.
BACKGROUND: The role of preformed and den novo formed DSA in LTX is not fully revealed. The aim of our study was to determine if…
2015 American Transplant Congress
Interference of Therapeutic Antibodies Used in Desensitization Protocols On Lymphocytotoxicity Crossmatch Results
D. Milongo,^1,3 G. Vieu,^2,4,3 S. Blavy,^2,4 A. Del Bello,^1,3 F. Sallusto,⁵ L. Rostaing,^1,3 N. Kamar,^1,3 N. Congy-Jolivet.^2,4,3
¹Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; ²Laboratoire d'Immunologie, CHU de Toulouse, Toulouse, France; ³Université Toulouse III Paul-Sabatier, Toulouse, France; ⁴Laboratoire d'Immunogénétique Moléculaire, EA 3034, Université Toulouse III Paul-Sabatier, Toulouse, France; ⁵Department of Urology, CHU Rangueil, Toulouse, France.
Background: Therapeutic antibodies used to desensitize patients awaiting a human leukocyte antigen (HLA) or ABO-mismatched graft are suspected to interfere with the lymphocytotoxicity crossmatch (LCT-XM)…
2015 American Transplant Congress
Part II: Rates and Determinants of Progression for De Novo Donor-Specific Antibody Mediated Kidney Allograft Injury
C. Wiebe,^1,2 I. Gibson,³ D. Pochinco,² P. Birk,⁴ T. Blydt-Hansen,⁴ J. Ho,^1,5 M. Karpinski,¹ A. Goldberg,⁴ L. Storsley,¹ D. Rush,¹ P. Nickerson.^1,2,5
¹Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Immunogenetics, Diagnostic Services of Manitoba, Winnipeg, MB, Canada; ³Pathology, University of Manitoba, Winnipeg, MB, Canada; ⁴Pediatric and Child Health, University of Manitoba, Winnipeg, MB, Canada; ⁵Immunology, University of Manitoba, Winnipeg, MB, Canada.
The development of de novo donor-specific antibody (dnDSA) is an independent predictor of allograft loss in renal transplantation. Rates and determinants of clinical pathologic progression…
2015 American Transplant Congress
Antibody Response Following Influenza Vaccination in Renal Transplant Recipients
M. Mujtaba, B. Book, A. Sharfuddin, A. Khalil, S. Vaishnav, E. Wiebke, M. Yaqub, D. Mishler, T. Taber.
Indiana University School of Medicne-IU Health, Indianapolis, IN.
Purpose: Following the recommended consensus guidelines of ATC for vaccination, at our institution we recommend annual vaccination for influenza + H1N1 (Flu) for renal transplant…
2015 American Transplant Congress
Clinical Outcome of Patients With De Novo C1q Binding Donor-Specific HLA Antibodies After Renal Transplantation
J. Bamoulid,¹ A. Roodenburg,² O. Staeck,¹ C. Schoenemann,² N. Lachmann,² K. Budde.¹
¹Nephrology, Charite Hospital-University of Medicine, Berlin, Germany; ²HLA Laboratory, Charite Hospital-University of Medicine, Berlin, Germany.
A. Not all de novo donor-specific HLA antibodies (dnDSA) are causing immediate graft loss. The importance of complement-binding DSA was recently shown with a commercial…
2015 American Transplant Congress
Deceased Donor HLA Antibody Incompatible Renal Transplantation Without Antibody Removal: High Incidence of Acute Rejection Reduced By T-Cell Depleting Induction Therapy
E. Jolly,¹ C. Taylor,² H. Morgan,² S. Peacock,² M. Clatworthy,¹ N. Torpey.¹
¹Division of Renal Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom; ²Tissue Typing Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Aims: Screening for HLA-specific antibodies (Ab) is routine for patients on kidney transplant waiting lists, and HLA antigens to which a patient has detectable Ab…
2015 American Transplant Congress
Impact of Donor Specific Antibodies in the Older Kidney Transplant Recipient
S. Patel, J. Loucks-DeVos, R. Knight, S. Kuten, L. Gaber, A. Gaber.
Houston Methodist Hospital, Houston.
Recent evidence suggests that renal transplant recipients (RTR) with both rejection and donor specific antibodies (DSA) are at high risk of graft loss. Concurrently, the…
2015 American Transplant Congress
Cognate Events in Antibody- Vs. T Cell-Mediated Rejection: A Molecular Perspective
M. Parkes,¹ P. Halloran,¹ L. Hidalgo.²
¹Department of Medicine, University of Alberta, Edmonton, AB, Canada; ²Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.
AIM: The cognate event in antibody-mediated rejection (ABMR) is NK cell FcR engagement; T cell mediated rejection (TCMR) uses TCR engagement. Understanding the molecular changes…
2015 American Transplant Congress
Early Antibody Mediated Rejection in HLA Antibody Incompatible Kidney Transplantation – A Treatable Condition Without Heavy Induction Immunosuppression
S. Daga,^1,2 N. Krishnan,¹ D. Lowe,³ F. Lam,¹ C. Imray,^1,2 H. Kashi,¹ L. Tan,¹ D. Briggs,³ R. Higgins.^1,2
¹Renal Department, University Hospital, Coventry, United Kingdom; ²Warwick Medical School, University of Warwick, Coventry, United Kingdom; ³H&I Department, NHSBT, Birmingham, United Kingdom.
Transplantation across preformed donor specific HLA antibodies (DSA) not only carries a risk of early acute antibody mediated rejection (AMR) and graft loss, but also…
2015 American Transplant Congress
Distinct Clinical Relevance of BAFF Expression Within the Kidney Graft and Soluble BAFF Serum Levels Indicate Confined Alloimmune Responses Disconnected from the Periphery
E. Campos,^1,2 K. Mine,¹ A. Goncalves-Primo,^1,2 M. Soares,⁴ M. Franco,² J. Medina-Pestana,^2,3 H. Tedesco-Silva,³ M. Gerbase-DeLima.^1,2
¹Instituto de Imunogenética, AFIP, São Paulo, SP, Brazil; ²Universidade Federal de São Paulo, São Paulo, SP, Brazil; ³Hospital do Rim e Hipertensão- FOR, São Paulo, SP, Brazil; ⁴Universidade Federal do Parana, Curitiba, PR, Brazil.
As soluble B-cell activating factor (BAFF) serum levels (sBAFF) may not reflect BAFF concentrations within the graft, what could be related to the inconsistencies in…