ATC Abstracts

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Articles tagged "HLA antibodies"

  • 2015 American Transplant Congress

    Evaluation of Preformed Anti-HLA Antibody of "Unknown Origin" after Kidney Transplant in a Brazilian Center

    D. Glasberg,1 D. Monteiro de Carvalho,2 T. Matuck,2 G. Fabricio-Silva,3 M. Barbosa,1 A. Borela,1 L. Christiani,1 R. Malta,1 L. Porto.3

    1Nephrology, Bonsucesso Federal Hospital, Rio de Janeiro, Brazil; 2Transplant Service, São Francisco de Assis Hospital, Rio de Janeiro, Brazil; 3Histocompatibility and Cryopreservation Laboratory, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

    Background: The use of single antigen beads assay (SAFB) for the detection of anti-HLA antibodies (Abs) may reveal the presence of Abs in individuals without…
  • 2015 American Transplant Congress

    Post Transplant De Novo Donor Specific Antibodies Correlate With the Development of Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation

    E. Melicoff, J. Maddox, M. Ebenbichler, J. Heinle, D. McKenzie, P. Jindra, G. Mallory, R. Kerman.

    Texas Children's Hospital, Houston, TX; Baylor College of Medicine, Houston, TX.

    HLA donor specific antibodies (DSA) have been associated with poor allograft survival following adult solid organ transplantation (Tx). However, there is little evidence implicating post-Tx…
  • 2015 American Transplant Congress

    Correlation Between C3d-Binding De Novo Donor Specific HLA Antibodies and Rejection in Kidney Transplant Recipients

    M. Cusick, K. Haarberg, J. Friedewald, A. Tambur.

    Comprehensive Transplant Center, Northwestern University, Chicago, IL.

    Donor specific antibodies (DSA) directed against HLA arising de novo post-kidney transplant are a major cause of graft loss, termed antibody mediated rejection (AMR). Currently,…
  • 2015 American Transplant Congress

    A Distinct Glomerular Complement Deposition Pattern in Transplant Glomerulopathy

    P. Verghese, R. Reed, A. Matas, Y. Kim.

    University of Minnesota, Minneapolis.

    While many patients with transplant glomerulopathy (TG) have donor-specific antibodies, the lack of C4d deposition in the peritubular capillaries (ptc-C4d) in some cases has caused…
  • 2015 American Transplant Congress

    Does Switching Predict Conversion: IgM De Novo Donor Specific HLA Antibodies Class Switch to IgG in Subclinical Antibody Mediated Rejection in Heart Transplant Recipients

    M. Askar,1 R. Rodriguez,1 L. Klingman,1 D. Thomas,1 A. Zhang,1 H. Morf,2 N. Hamon,1 N. Moazami,1 E. Hsich,1 D. Taylor,1 R. Starling,1 C. Tan.1

    1Cleveland Clinic, Cleveland; 2School of Medicine, Leipzig University, Leipzig, Germany.

    Background: Concomitant C4d and C3d detection in heart biopsies correlates with circulating DSA and graft dysfunction. Detection of C4d only in surveillance biopsies is not…
  • 2015 American Transplant Congress

    Assessment of IgG Subclass Significance for Early Graft Rejection and Long-Term Survival in HLA-Antibody Incompatible Renal Transplantation: Multivariate Approach

    N. Khovanova,1 D. Lowe,2 S. Daga,1,3 T. Shaikhina,1 N. Krishnan,3 D. Mitchell,1 D. Zehnder,1 D. Briggs,2 R. Higgins.3

    1University of Warwick, Coventry, United Kingdom; 2NHS Blood and Transplant, Birmingham, United Kingdom; 3University Hospitals Coventry and Warwickshire, Coventry, United Kingdom.

    Donor HLA specific antibodies (DSA) can cause acute rejection and graft lost after renal transplantation. However neither the damaging antibody types, nor their acceptable levels…
  • 2015 American Transplant Congress

    Antibodies Directed Against HLA-DQ Are Significantly Associated to Complement Activation In Vitro

    J. Arreola-Guerra, A. de Santiago, A. Arvizu, N. Gonzalez-Tableros, M. Lopez, M. Vilatoba, L. Morales-Buenrostro, J. Alberu, N. Castelan.

    1Transplantation, 1aNephrology-Mineral Metabolism, Inst Nal de Ciencias Medicas y Nutricion SZ, Mexico City, Distrito Federal, Mexico.

    Background: C1q-binding HLA antibodies (HLAabs) have been related to acute rejection and long-term graft loss. The characteristics of these antibodies and factors associated to complement…
  • 2015 American Transplant Congress

    Post-Kidney Allograft Nephrectomy Anti-HLA Immunization Is Not Due to a Release of Anti-HLA Antibodies from the Failed Kidney

    D. Milongo,1,3 N. Congy-Jolivet,2,3,4 A. Del Bello,1,3 F. Sallusto,5 C. Guilbeau-Frugier,6 L. Rostaing,1,3 N. Kamar.1,3

    1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; 2Laboratoire d'Immunologie, CHU de Toulouse, Toulouse, France; 3Université Toulouse III Paul-Sabatier, Toulouse, France; 4Laboratoire d'Immunogénétique Moléculaire, EA 3034, Université Toulouse III Paul-Sabatier, Toulouse, France; 5Department of Urology, CHU Rangueil, Toulouse, France; 6Department of Histopathology, CHU Rangueil, Toulouse, France.

    Background and aims: The reasons for the increased incidence of de novo anti-HLA donor specific antibodies (DSAs) that is observed after kidney allograft nephrectomy (NTx)…
  • 2015 American Transplant Congress

    Intermittent High Dose Intravenous Immunoglobulin as Treatment for Donor Specific Antibodies in Renal Transplant Recipients

    P. Bolin,1 K. Parker,2 F. Rana,1 W. Bryant,1 P. Jawa,1 R. Harland.3

    1Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 2Vidant Medical Center, Greenville, NC; 3Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC.

    Background: Donor-specific HLA antibody (DSA) formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population have indicated…
  • 2015 American Transplant Congress

    Prediction of Acute Antibody Mediated Rejection in Antibody Incompatible Renal Transplantation Using Machine Learning for Wide Data

    T. Shaikhina,1 N. Khovanova,1 S. Daga,1,3 N. Krishnan,2 D. Lowe,3 D. Mitchell,1 D. Briggs,2 R. Higgins.3

    1University of Warwick, Coventry, United Kingdom; 2NHS Blood and Transplant, Birmingham, United Kingdom; 3University Hospitals Coventry and Warwickshire, Coventry, United Kingdom.

    The dynamic field of renal transplantation is characterised by limited access to data, the high cost of equipment and underlying complexity of immunological responses to…
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