2017 American Transplant Congress
Lower Mean Tacrolimus Troughs Increase Risk of De Novo Donor-Specific Antibodies in the First Year of Kidney Transplant.
University of Colorado, Aurora, CO
Development of de novo donor-specific antibodies (dnDSA) is the first step in the evolution of antibody-mediated rejection, which constitutes the leading cause of death-censored graft…2017 American Transplant Congress
Complement Activating Anti-HLA Antibodies: Identification of Specific Histo-Mmolecular Phenotype of Rejection for Complement-Targeting Therapy.
Addressing the heterogeneity of antibody-mediated allograft rejection by identifying phenotypes based on pathophysiology is critical for improving outcomes in transplantation. We investigated whether complement-binding anti-HLA…2017 American Transplant Congress
Blood Transfusion Before Organ Transplant: Patient Sensitization and Outcomes.
Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
BackgroundBlood transfusions (Btf) can cause alloimmunization to HLA antigens. Antibodies to HLA (HLAb) can increase patients' calculated panel reactive assay (cPRA) and make it more…2017 American Transplant Congress
Association of Non-HLA Antibodies with Histological Changes of Antibody Mediated Injury in Kidney Transplantation.
1Division of Nephrology, University of Washington, Seattle; 2Bloodworks NW, Seattle
Solid phase assays, particularly single-antigen beads, have substantially increased the sensitivity and accuracy of antibody detection in transplantation. However, donor specific antibodies(DSA) against human leukocyte…2017 American Transplant Congress
Clinical Impact of Strength and Class of Pre transplant Donor Specific Antibody on Kidney Transplant Recipient Receiving Steroid Free Maintenance Immunosupression Regimen.
Renal Transplant, Indiana University School of Medicine, Indianapolis, IN
Background: The class and strength of pre- transplant DSA has been described as playing a role in determining future risk of acute rejection (AR) and…2016 American Transplant Congress
DSA After Transplant Increases Risk of Renal Allograft Failure Independent of Concurrent Biopsy Results: The DEKAF Study Data.
Donor-specific HLA antibodies (DSA) are a major cause of renal allograft dysfunction and loss following transplant. The presence of DSA, with or without C4d deposition,…2016 American Transplant Congress
Kidney Graft Homing of De Novo Donor Specific HLA Antibodies Is an Early Step within the Antibody-Mediated Graft Damage Process.
In this study, by a parallel analysis on sera and graft biopsies we have analyzed, in a pediatric cohort of unsensitized recipients of a first…2016 American Transplant Congress
Enhanced Natural Killer Responsiveness Is a Potent Cytotoxic Mechanism Associating to Kidney Allograft Dysfunction and Pathogenic Effects of Donor-Specific Antibodies (DSA).
While antibody mediated rejection (ABMR) is a major cause of kidney transplant loss, the role of Natural Killer cells (NK) as immune effectors of complement-independent…2016 American Transplant Congress
Factors Predicting Risk for Antibody-Mediated Rejection in Highly Sensitized Pediatric Renal Transplants.
Introduction: Antibody-mediated rejection (ABMR) is a concern in highly sensitized (HS) patients (pts) receiving renal transplant (tx). We have previously published that a donor specific…2016 American Transplant Congress
Analysis of Intra-Graft Anti-HLA Antibodies Suggests That HLA Sensitization Occurs Long After an Allograft Nephrectomy and Is Not Due to a Release of Anti-HLA Antibodies from the Failed Kidney.
Background: The mechanism leading to the appearance of anti-HLA antibodies and donor-specific antibodies (DSAs) after an allograft nephrectomy (NTx) is not fully understood. Two mechanisms…
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