2017 American Transplant Congress
Prediction of Positive Cytotoxic and Flow Crossmatches for Sensitized Wait List Candidates: Comparison of Luminex MFI, C1q and FcR Binding Assays.
Surgery, University of Cincinnati, Cincinnati
Clinical relevance of HLA antibodies identified in solid phase assays includes their ability to generate a positive crossmatch (XM) test, which often precludes transplantation. The…2017 American Transplant Congress
Experience with the Bacterial Enzyme IdeS (IgG Endopeptidase) for Desensitization of Highly-HLA Sensitized (HS) Kidney Allograft Recipients.
Donor specific antibodies (DSA) create an impenetrable immunologic barrier to transplantation. Current rx aimed at modification of DSAs are not effective in the most HS…2017 American Transplant Congress
Circulating Donor-Specific Memory B Cells (mBc) Discriminates Kidney Transplant Patients with Histological Lesions of ABMR in Absence of Circulating DSA.
Chronic (c)ABMR is a main cause of immune-mediated kidney allograft loss. For its diagnosis, specific histological lesions together with presence of circulating donor-specific alloantibodies (DSA)…2017 American Transplant Congress
Outcome of Systemic Monitoring of DSA and Protocol Management to Optimize Renal Allograft Outcome in a Single Transplant Center.
Denovo (dn) donor specific antibody (DSA) development has been shown to adversely affect long-term allograft survival. To improve graft outcome for kidney (K) transplant (Tx)…2017 American Transplant Congress
Impact of Serum EDTA Treatment on Identification of Unacceptable Antigens for Kidney Transplant Candidates.
Pathology, University of Chicago Medicine, Chicago, IL
BACKGROUND AND AIMS: The prozone effect is one factor causing false negative reactions in HLA antibody testing. EDTA, which is commonly used to remove this…2016 American Transplant Congress
De Novo Anti-HLA DSA Characteristics and Subclinical Antibody Mediated Kidney Allograft Injuries.
Nagoya daini red cross hospital, Nagoya, Japan.
Background It has been reported that de novo donor-specific HLA antibody (dn DSA) production is associated with chronic antibody-mediated rejection (CAMR) which leads to poor…2016 American Transplant Congress
Anti-HLA Antibody Composition and Outcomes in Pediatric Heart Transplant Recipients with a Positive Cross-Match.
Purpose: Utilization of positive (+) cross-match (XM) hearts is tempting when shortages of pediatric donor hearts exist, especially for patients with high pre-transplant panel reactive…2016 American Transplant Congress
Optimizing CPRAs for Sensitized Kidney Waitlist Candidates: The Devil Is in the KAS Details.
The new kidney allocation system (KAS) has increased transplant rates for highly sensitized candidates. We hypothesized that increasing unacceptable antigens to transition candidates from 80-98%…2016 American Transplant Congress
Long Term Outcomes Following Antibody Mediated Rejection (AMR) in Renal Transplant Recipients.
Columbia University, New York.
INTRO: Progress in AMR treatment has improved early graft survival. Since the new kidney allocation system results in more sensitized patients getting transplanted, we expect…2016 American Transplant Congress
Dilution of Patient Sera Improves MFI Correlation with Complement Fixation in Solid Phase Assay Assessment.
Background: Median Fluorescent Intensity (MFI) by solid phase assays (SPA) has been used to determine risk of donor-recipient reaction prior to transplant. Inconsistency of this…
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