Articles tagged "HLA antibodies"

2017 American Transplant Congress
Incidence of De Novo Donor-Specific Antibodies Following Kidney Transplantation.
B. Ho,¹ H. Bhagat,² E. Lee,^2,3 K. Atiemo,¹ A. Daud,¹ R. Kang,¹ S. Montag,^1,4 L. Zhao,^1,4 J. Schwartz,² D. Ladner.¹
¹Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago; ²Astellas Pharma Global Development, Northbrook; ³Now with UCB, Atlanta; ⁴Dept of Preventive Medicine, Northwestern University, Chicago
With a range of frequencies reported in several small studies, true incidence of de novo donor-specific human leukocyte antigen (HLA) antibodies (dnDSA) is unknown. As…
2017 American Transplant Congress
Effect of Preformed Donor-Specific Antibodies in Intestine/Multivisceral Transplantation.
M. Safwan,¹ M. Rizzari,¹ K. Collins,¹ A. Yoshida,¹ S. Skorupski,² O. Fagoaga,² M. Abouljoud,¹ S. Nagai.¹
¹Divison of Transplant and Hepatobiliary Surgery, Henry Ford Transplant Institute, Detroit, MI; ²Transplant Immunology, Henry Ford Hospital, Detroit, MI
Aim: To analyze the effect of preformed donor-specific antibodies (DSA) in intestine/multivisceral transplantation patients.Methods: Retrospective review of preformed and de novo DSAs of all intestine/multivisceral…
2017 American Transplant Congress
Outcome of Living-Donor Kidney Transplantation in Cross-Match-Positive Recipients at a Single Center.
D. Okada,¹ M. Okumi,¹ K. Unagami,² T. Shimizu,¹ H. Ishida,¹ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Nephrology, Tokyo Women's Medical University, Tokyo, Japan
BackgroundLiving-donor kidney transplantation in cross-match (XM)-positive patients remains high-risk and requires an optimal desensitization protocol. We started a desensitization protocol for XM-positive patients in January…
2017 American Transplant Congress
Is the Time of Appearance and Resolution of De Novo HLA-DP Donor Specific Antibodies Associated with Reduced Deleterious Effect on Lung Transplant Outcomes?
A. Zhang,¹ Y. Sun,² K. McCurry,³ M. Budev.³
¹Allogen Laboratories, Cleveland Clinic, Cleveland, OH; ²Avalon University School of Medicine, Willemstad, Netherlands Antilles; ³Transplantation Center, Cleveland Clinic, Cleveland, OH
Introduction: The impact of HLA-DP de novo donor specific antibodies (dDSA) to lung transplantation (LT) is poorly understood. This study analyzed the association of timely…
2017 American Transplant Congress
Tacrolimus Time in Therapeutic Range Predicts Adverse Clinical Outcomes in the First Year of Kidney Transplant.
S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.
University of Colorado, Aurora, CO
Tacrolimus (TAC) has a narrow therapeutic range, with its upper bounds limited by serious toxicities while TAC minimization strategies have demonstrated immunologic risk. Monitoring the…
2017 American Transplant Congress
Determinants of Severe Interstitial Fibrosis in Kidney Allografts: Major Impact of Circulating Donor-Specific Anti-HLA Antibodies.
C. Gosset, D. Viglietti, M. Rabant, E. Pillebout, J. Taupin, D. Glotz, C. Legendre, J. Duong Van-Huyen, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France
Interstitial fibrosis represents a major cause of kidney allograft failure. We investigated the independent contribution of circulating donor-specific anti-HLA antibodies (DSA) in the development of…
2017 American Transplant Congress
IgG Antibody Subclasses in Potential Renal Transplant Recipients with DSA, AHG-CDC CxM Negative and FxM Positive or Negative with Their Potential Donors.
A. Contreras, A. Casillas, L. Llorente, G. Lima, A. Arvizu, A. De Santiago, M. Vilatoba, J. Alberu, J. Arreola-Guerra.
Transplantation Departament, 1b Immunology Department, Inst Nal Ciencia Medicas y Nutricion SZ, Mexico City, Mexico
Background. In kidney transplant recipients, IgG3 and IgG4 DSA have been associated with shorter time to acute AMR and with later allograft injury (glomerulopathy &…
2017 American Transplant Congress
Development of an Anti-HLA Antibody-Producing Humanized Mouse Model.
S. Yanagawa, H. Tahara, H. Ohdan.
Hiroshima University, Hiroshima, Japan; Hiroshima University, Hiroshima, Japan; Hiroshima University, Hiroshima, Japan
Chronic antibody-mediated rejection due to anti-human leukocyte antigen (HLA) antibodies (Abs) is an important problem in organ transplantation. The spleen has been reported to be…
2017 American Transplant Congress
Predicting Immunologic Risk for Acute Rejection in Pediatric Liver Transplantation.
S. Antala, L. Bow, R. Morotti, G. Gan, D. Yanhong, U. Ekong, S. Emre.
Yale University, New Haven, CT
Background: Studies in heart, lung, kidney, & liver transplantation (LT) indicate an increased negative impact of antibodies (Ab) to HLA on allograft outcome.Aim: To describe…
2017 American Transplant Congress
Clinical Outcomes of ABO and HLA Incompatible Kidney Transplantation – Nationwide Cohort Study.
E. Ko,^1,2 J. Yu,^1,2 C. Yang,^1,2 B. Chung,^1,2 Korean Organ Transplantation Registry (KOTRY).
¹Transplantation Research Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; ²Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Background This is a nationwide cohort study to investigate the impact of anti-A/B antibody or donor specific anti-HLA antibody (HLA-DSA) on the clinical outcomes in…