Articles tagged "HLA antibodies"

2018 American Transplant Congress
Evaluation of FlowDSA Crossmatch for Detection of Donor-Specific HLA Antibodies
J. Lee, J. Ryu, A. Choi, E-.J. Oh.
Laboratory Medicine, Seoul St. Mary's Hospital, the Catholic University of Korea, Seoul, Republic of Korea.
Background: Donor-specific HLA antibodies (DSA) are detected by different crossmatch techniques. Flow cytometric crossmatching (FCXM) is sensitive method, but it is subject to false (+)…
2018 American Transplant Congress
Interstitial Inflammation is Correlated with DQ Antibodies in Kidney Transplant Recipients
C. Harris, L. Anderson, R. Khaim, J. Choudhuri, R. Shapiro, S. Florman, F. Salem, M. Menon.
Icahn School of Medicine at Mount Sinai, New York.
Background: Studies have shown that borderline rejection (BR) and acute cellular rejection (ACR) often co-occur with antibody-mediated rejection (AMR). We examined the association between interstitial…
2018 American Transplant Congress
Functional Fc Gamma Receptor Gene Polymorphisms and Donor-Specific Antibody-Triggered Transplant Injury
M-.L. Arnold,¹ A. Kainz,² F. Eskandary,² N. Kozakowski,³ M. Wahrmann,² H. Haslacher,⁴ R. Oberbauer,² A. Heilos,⁵ B. Spriewald,⁶ L. Hidalgo,⁷ P. Halloran,⁸ G. Bohmig.²
¹Department of Internal Medicine 3, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; ²Department of Medicine III, Medical University of Vienna, Vienna, Austria; ³Department of Pathology, Medical University of Vienna, Vienna, Austria; ⁴Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; ⁵Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria; ⁶Department of Internal Medicine 5, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; ⁷Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ⁸Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada.
Fc-dependent effector mechanisms may play an important role in antibody-mediated rejection (ABMR). Distinct gene polymorphisms may determine the function of Fc gamma receptors (FcγR), potentially…
2018 American Transplant Congress
Bortezomib in Late Antibody-Mediated Kidney Transplant Rejection – A Double-Blind Randomized Placebo-Controlled Trial (BORTEJECT Study)
F. Eskandary,¹ H. Regele,² G. Bond,¹ N. Kozakowski,² M. Wahrmann,¹ L. Hidalgo,³ H. Haslacher,⁴ C. Kaltenecker,¹ M-.B. Aretin,⁵ R. Oberbauer,¹ J. Reeve,⁶ P. Halloran,⁶ G. Böhmig.¹
¹Nephrology and Dialysis, Medical University Vienna, Viena, Austria; ²Institute of Clinical Pathology, Medical University Vienna, Vienna, Austria; ³Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ⁴Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria; ⁵Pharmacy Department, General Hospital Vienna, AKH, Vienna, Austria; ⁶Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada.
Background. Antibody-mediated rejection (ABMR) is a leading cause of long-term kidney transplant loss. Optimal treatment of late ABMR is unclear, and our current knowledge is…
2018 American Transplant Congress
Peripheral Blood Immune Response-Related Gene Analysis for Evaluating the Development of Subclinical Antibody-Mediated Rejection
T. Yamamoto,¹ K. Iwasaki,² K. Murotani,³ A. Takeda,⁴ M. Tsujita,⁴ T. Hiramitsu,⁴ N. Goto,⁴ S. Narumi,⁴ Y. Watarai,⁴ K. Uchida,² T. Kobayashi.⁵
¹Xenotransplantation, University of Alabama at Birmingham, Birmingham, AL; ²Kidney Disease and Transplant Immunology, Aichi Medical University, Nagakute, Japan; ³Biostatistics, Aichi Medical University, Nagakute, Japan; ⁴Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ⁵Renal Transplant Surgery, Aichi Medical University, Nagakute, Japan.
Background: Noninvasive methods for the early diagnosis of chronic antibody-mediated rejection (cAMR) are desired for patients with de novo (dn) donor-specific HLA antibody (DSA) because…
2018 American Transplant Congress
Clinical Heterogeneity of Early Anamnestic Donor Specific Antibody Responses in Kidney Transplantation
A. Loethen,¹ A. Lichvar,¹ S. Tremblay,¹ A. Shields,^1,2 A. Dao,¹ M. Cardi,² P. Brailey,¹ A. Girnita,¹ B. Abu Jawdeh,¹ R. Alloway,¹ E. Woodle.¹
¹U of Cincinnati, Cincinnati, OH; ²Christ Hospital, Cincinnati, OH.
Anamnestic donor specific antibody(DSA) responses in the early post-transplant period may threaten the renal transplant(RTx). We hypothesize earlier DSA detection will allow minimization of RTx…
2018 American Transplant Congress
Lower Incidence of De Novo Donor-Specific Antibodies against HLA-DR in ABO-Incompatible Renal Transplantation
M. Okada,¹ K. Futamura,¹ T. Hiramitsu,¹ M. Tsujita,¹ N. Goto,¹ S. Narumi,¹ Y. Watarai,¹ K. Iwasaki,² T. Kobayashi.²
¹Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ²Department of Transplant Surgery, Aichi Medical University, Nagakute, Japan.
IntroductionDe novo DSA-induced chronic antibody-mediated rejection (AMR) is one of major obstacles to long term graft survival. We have reported that anti-A/B antibody binding could…
2018 American Transplant Congress
Isolated Pre-Transplant Angiotensin II Type I Receptor Antibodies (AT1R Ab) Are Not Associated with Reduced Graft Function or Hypertension (HTN) in Pediatric Kidney Transplant (Ped KTx) Patients (pts)
H. Pizzo, J. Choi, M. Haas, X. Zhang, E. Kamil, I. Kim, S. Jordan, D. Puliyanda.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Pre-tx donor-specific antibodies (DSA) raises the risk for antibody-mediated rejection (ABMR) and graft dysfunction. The role of AT1R Ab is unclear. In adults, post-tx…
2018 American Transplant Congress
Defining Response to Standard of Care Treatment in Kidney Recipients with Antibody-Mediated Rejection: Role of C1q-Binding Donor-Specific Anti-HLA Antibodies
Y. Bouatou, D. Viglietti, O. Aubert, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France.
A major hurdle to improving clinical care in kidney transplantation is the lack of biomarkers of the response to antibody-mediated rejection (ABMR) treatment. We investigated…
2018 American Transplant Congress
The Clinical Significance of Pretransplant C1q Assay Status in Positive Crossmatch Kidney Transplantation
J. Lee,¹ D. Kim,¹ B. Park,² S. Song,³ J. Lee,⁴ Y. Jung,¹ J. Lee,¹ J. Lee,¹ B. Kim,⁵ M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹
¹Surgery, Yonsei University College of Medicine, Seoul, Korea; ²Laboratory Medicine, Asan MEdical Center, Seoul, Korea; ³Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; ⁴Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; ⁵Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.
Background: Patients with a pretransplant donor-specific antibodies (DSA) are at higher risk for antibody-mediated rejection (AMR). However, not all DSA have the same pathogenetic potential.…