Articles tagged "HLA antibodies"

2020 American Transplant Congress
A Simple HLA Class II Matching Strategy for the Prediction of De Novo Donor-Specific HLA Antibodies
L. G. Hidalgo¹, I. A. Martinez Juarez², L. Morales-Buenrostro³, S. Shojai⁴, P. Campbell⁴
¹Surgery, University of Wisconsin - Madison, Madison, WI, ²Nephrology, Hospital Angeles Pedregal, Mexico City, Mexico, ³Nephrology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ⁴Medicine, University of Alberta, Edmonton, AB, Canada
*Purpose: In kidney transplantation, degree of HLA Class II mismatch (MM) between donor and recipient drives the risk to develop de novo DSA (dnDSA). New…
2020 American Transplant Congress
Impact of Catch-Up Vaccinations on Anti-HLA Antibody Responses in Pediatric Kidney Transplant Candidates
H. Sweiss¹, J. Lyons², R. Hall¹, K. Hitchman³, D. Ranch⁴, E. Kincaide¹, B. Crowther⁵
¹University Health System, San Antonio, The University of Texas Health Science Center at San Antonio, San Antonio, TX, ²Loyola University Medical Center, Chicago, IL, ³University Health System, San Antonio, TX, ⁴The University of Texas Health Science Center at San Antonio, San Antonio, TX, ⁵University of Colorado Health, Aurora, CO
*Purpose: Evaluate antibody (Ab) response after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC less than or equal…
2020 American Transplant Congress
Pre-Transplant Detection of Anti-at1r Antibodies and Pediatric Kidney Transplantation Outcomes
K. Hitchman¹, C. Usenko², R. Hinojosa¹, D. Ranch¹
¹UT Health San Antonio, San Antonio, TX, ²University Health System, San Antonio, TX
*Purpose: Describe correlations between pre-transplant (PreTXP) presence of anti-angiotensin II receptor type 1 antibodies (AT1R Ab) and post-transplant (PostTXP) outcomes in a pediatric kidney transplant…
2020 American Transplant Congress
Bone Marrow Plasma Cell Heterogeneity Drives Resistance of Proteasome Inhibitor Therapy
C. M. Castro-Rojas¹, S. Tremblay², J. Driscoll³, K. Roskin⁴, R. R. Alloway³, E. Woodle², D. A. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH, ²Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, ³Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, ⁴Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH
*Purpose: Patients sensitized to HLA antigens by prior transplantation, pregnancy or blood transfusion may have markedly prolonged waiting times for transplant. Moreover, once transplanted, the…
2020 American Transplant Congress
Liver Transplant Recipients with High DSA at Time of Transplant Do Not Have Increased Rejection or Mortality
A. Demirag¹, B. Rawashdeh¹, S. L. Lennon¹, S. Pelletier¹, J. Iezzoni², K. Khutsisvhili³, S. Shumilina¹, K. Chittum¹, J. Oberholzer¹, P. Lobo⁴
¹Department of Surgery, University of Virginia Medical Cener, Charlottesville, VA, ²Department of Pathology, University of Virginia Medical Cener, Charlottesville, VA, ³Histocompatibility Laboratory, University of Virginia Medical Cener, Charlottesville, VA, ⁴Department of Medicine, University of Virginia Medical Cener, Charlottesville, VA
*Purpose: Currently, there is controversy regarding transplanting livers in setting of high HLA-class ll DSA especially since prior studies demonstrated enhanced acute rejections in this…
2020 American Transplant Congress
Influence of Human Leukocyte Antigen Status and Gender of Positive Crossmatch Patients on Long-Term Survival Outcomes of Antibody Incompatible Renal Transplantation
N. R. Macha¹, A. Abimbola¹, N. Khovanova², D. Briggs³, N. Krishnan⁴
¹CIRAL, Coventry University, Coventry, United Kingdom, ²School of Engineering, University of Warwick, Warwickshire, United Kingdom, ³Director, Tissue Typing Lab, NHSBT, Birmingham, United Kingdom, ⁴Consultant Transplant Nephrologist and Visiting Professor, CIRAL, University Hospital Coventry & Warwickshire, Coventry, United Kingdom
*Purpose: Human Leukocyte Antigen (HLA) sensitization is a significant obstacle which limits the use of renal transplantation, but it serves as a therapeutic option for…
2020 American Transplant Congress
Significance of DSA Clearance in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients on 1 Year Outcomes: Interim Results from PARAMOUr “Pediatric Renal AMr Outcomes” Study
I. Ashoor¹, R. Garro², S. Solomon³, A. Jain⁴, M. Kallash⁵, K. Twombley⁶
¹LSHUSC Children's Hospital New Orleans, New Orleans, LA, ²Emory University School of Medicine, Atlanta, GA, ³New York Medical College, Valhalla, NY, ⁴Wayne State University School of Medicine, Detroit, MI, ⁵Nation Wide Children's Hospital, Columbus, OH, ⁶Medical University of South Carolina, Charleston, SC
*Purpose: Little is known about how donor specific antibody (DSA) clearance correlates with outcomes in pediatric antibody mediated rejection (AMR). There is also little data…
2020 American Transplant Congress
Quantitative Analysis of Humoral Immunity by Flow-Cytometric Crossmatch Using Molecules of Equivalent Soluble Fluorochromosome (FCXM-MESF)
H. Ishida, M. Furusawa, T. Shimizu, M. Okumi, Y. Kakuta, K. Omoto, K. Tanabe
Tokyo Womens, Tokyo, Japan
*Purpose: In this study, we examined the quantitative significance of humoral immunity by flow-cytometric crossmatch using molecules of equivalent soluble fluorochromosome (FCXM-MESF) in recipients of…
2019 American Transplant Congress
Anti-HLA IgM Antibodies Are Reduced in Highly-HLA Sensitized Patients Transplanted after Imlifidase (IdeS) Treatment
X. Zhang¹, S. Jordan²
¹HLA and Immunogenetics Laboratory, Comprehensive Transplant Center, Cedars-Sinai Health System, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Health System, Los Angeles, CA
*Purpose: Immunoglobulin-degrading enzyme from Streptococcus pyogenes (IdeS, Imlifidase) has been used to reduce antibody levels to promote transplant of highly sensitized patients. In vitro experiments…
2019 American Transplant Congress
MELD Score and Anti-Angiotensin Receptor Antibody Predict Long-Term Survival of Liver Re-Transplant
Q. Xu¹, A. Skaro², V. C. McAlister²
¹Pathology and Lab Medicine, London Health Science Center, London, ON, Canada, ²Surgery, London Health Science Center, London, ON, Canada
*Purpose: Recent reports indicated important while inconsistent roles of preformed donor specific antibody (DSA) to HLA in liver transplantation. Re-transplant liver patients were understudied due…