2019 American Transplant Congress
Living Kidney Donor Time Zero Biopsy Findings Predict Graft Loss in the Recipient
*Purpose: Recipient outcomes with living donor kidney grafts are superior to those achieved from deceased donors. However, there may still be variability in the quality…2019 American Transplant Congress
Prevention of Diabetic Nephropathy after Kidney Transplantation Requires More Than Pursuing Low Levels of Glycated Hemoglobin
*Purpose: Diabetic nephropathy is the leading cause of end-stage renal disease and progresses in five stages. During the second stage, morphologic lesions develop, without signs…2018 American Transplant Congress
Renal Allograft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation
Background: Chronic exposure to immunosuppressive agents for organ transplant results in graft nephrotoxicity, infections and malignancies We have established durable immune tolerance in mismatched related…2018 American Transplant Congress
Functional Reconstruction of Urogenital Tissue Defects Using VCA: A Novel Microsurgical Penis Transplant Model and Clinical & Histological Rejection Classification
Background: Defects of male urogenital structures subsequent to major trauma are associated with severely reduced function and quality-of-life. As of recent, penis transplantation represents an…2018 American Transplant Congress
Scoring Transplant Glomerulopathy Using Morphometry: Correlation with Banff Criteria
William J.von Liebig Transplant Center, Mayo Clinic, Rochester, MN.
Background: Transplant glomerulopathy (TG) is a prognostic marker for graft survival. Still, scoring TG using the Banff cg-score remains a challenge and no assessments in…2018 American Transplant Congress
Pre-Existing Allograft Diabetic Nephropathy from Diabetic Donor is Reversible after Kidney Transplantation in Non-Diabetic Recipient
1Hokkaido University Hospital, Sapporo, Japan; 2Sapporo City General Hospital, Sapporo, Japan.
【Introduction】The shortage of kidney donor has limited the treatment of patients with end-stage kidney disease. To use diabetic donor with normal renal function is would…2018 American Transplant Congress
Nephrosclerosis beyond That Expected for Age is Predictive of Early New-Onset Hypertension (HTN) in Living Kidney Donors (LKD)
1Mayo Clinic, Rochester, MN; 2Mayo Clinic, Scottsdale, AZ; 3Cleveland Clinic, Cleveland, OH.
Background: Nephrosclerosis on biopsy (bx) of LKD is associated with older age & HTN. We studied whether nephrosclerosis is predictive of adverse changes early after…2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…2018 American Transplant Congress
A Novel Preservation Solution for Lung That Improves Cell Viability and Tissue Architecture
1Tulane University, New Orleans; 2MUSC, Charleston.
Backgroud: Only 20% of donor lungs are used for transplant and 10 y survival of recipients is low. Many patients die within 30 d of…2018 American Transplant Congress
An Integrative Approach for the Assessment of Peritubular Capillaritis Extent and Score in Microvascular Inflammation – Association with Transplant Glomerulopathy and Graft Loss
Background:Banff Classification accepts two histomorphological features as surrogates of HLA Antibody-Antigen interaction on renal endothelium: C4d staining and microvascular inflammation scores (MVI sum score:ptc+g≥2) which…
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