Articles tagged "Histology"

2020 American Transplant Congress
The Composite Molecular and Cellular Instability Score Identifies the Sub-Phenotypes of Histologically Stable Kidney Transplants
D. Rychkov
Department of Surgery, BCHSI, University of California San Francisco, San Francisco, CA
*Purpose: Recent molecular studies have highlighted the unrecognized burden of sub-clinical graft rejection of a histologically stable allograft, defined as transplants with absence of clinical…
2020 American Transplant Congress
Risk of Histological Relapse in Patients with Monoclonal Gammopathy of Renal Significance after Kidney Transplantation
A. Bentall¹, C. Heybeli², F. G. Cosio¹, M. El Ters¹, N. Leung¹, M. P. Alexander³
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ²Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey, ³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
*Purpose: There is increased recognition of Monoclonal Gammopathy of Renal Significance (MGRS) but data on kidney transplant (ktx)outcomes are lacking. We assessed KTX outcomes of…
2020 American Transplant Congress
Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies
I. Moinuddin¹, D. Kumar¹, L. Kamal¹, A. King¹, L. Kang¹, M. Levy¹, S. Bobba¹, D. Massey¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
2020 American Transplant Congress
Chronic Active T-Cell Mediated Rejection is Variably Responsive to Immunosuppressive Therapy
V. Kung¹, M. Haas¹, M. Gillespie², E. Huang², R. Sandhu²
¹Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Chronic active T cell-mediated rejection (CACMR) is a newly described variant of kidney allograft rejection associated with long-term graft loss. A key histologic feature…
2020 American Transplant Congress
Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation
A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall
Mayo Clinic, Rochester, Rochester, MN
*Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
2020 American Transplant Congress
Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?
C. M. Edwards¹, J. T. Langford¹, M. Reschke², J. R. DiRito¹, D. Mulligan¹, D. Haakinson¹, G. T. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale University, New Haven, CT
*Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
2020 American Transplant Congress
Computer-Assisted Cardiac Histologic Evaluation (CACHE) for Grading Cardiac Allograft Rejection
E. Peyster¹, S. ArabYarmohommadi², A. Janowczyk², M. Sekulic³, C. Cassol⁴, M. Feldman¹, K. Margulies¹, A. Madabhushi²
¹University of Pennsylvania, Philadelphia, PA, ²Case Western Reserve University, Cleveland, OH, ³University Hospitals Cleveland Medical Center, Cleveland, OH, ⁴Ohio State University, Columbus, OH
*Purpose: Cardiac allograft rejection (CAR) is a serious concern in heart transplantation, occurring in 30-40% of patients during the first year. Endomyocardial biopsy (EMB) with…
2019 American Transplant Congress
Eculizumab Deposition in Renal Transplants
D. WANG¹, S. H. Nasr¹, A. B. Farris², C. A. Schinstock³, M. P. Alexander¹, L. D. Cornell¹
¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, ²Pathology & Laboratory Medicine, Emory University, Atlanta, GA, ³Division of Nephrology & Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN
*Purpose: Eculizumab is a recombinant humanized IgG monoclonal antibody that inhibits C5, thereby preventing the activation of C5a and formation of membrane attack complex C5b-C9.…
2019 American Transplant Congress
Kinetics of Pretransplant DSA, Post-Transplant Histology, and Graft Failure after Kidney Transplantation
A. Senev¹, E. Lerut², V. Van Sandt³, J. Callemeyn¹, M. Coemans¹, B. Sprangers², D. Kuypers², M. Emonds¹, M. Naesens²
¹Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, ²University Hospitals Leuven, Leuven, Belgium, ³Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium
*Purpose: The association between the kinetics of pretransplant DSA levels and outcome after kidney transplantation is currently not well known. In this large cohort study…
2019 American Transplant Congress
Recurrent Diabetic Nephropathy Despite Intensive Glycemic Control: An Observational Cohort Study
M. Coemans, E. Van Loon, E. Lerut, D. Kuypers, B. Sprangers, P. Gillard, C. Mathieu, G. Verbeke, M. Naesens
KU Leuven, Leuven, Belgium
*Purpose: After kidney transplantation, recurrence of diabetic nephropathy has been reported. The presentation and kinetics of recurrent diabetic nephropathy and its risk factors remain however…