ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histology"

  • 2016 American Transplant Congress

    The Effect of Everolimus and Tacrolimus Exposure Levels on Renal Histology Parameters 6 Months Post-Transplantation.

    S. Yilmaz,1 D. Shaffer,2 Y. Qazi,3 K. McCague,4 D. Patel,4 V. Peddi,5 F. Vincenti.6

    1University of Calgary, Calgary, Canada; 2Vanderbilt University, Nashville; 3University of Southern California, Los Angeles; 4Novartis Pharmaceuticals Corporation, East Hanover; 5California Pacific Medical Center, San Francisco; 6University of California San Francisco, San Francisco.

    We examined renal histology scores in patients with different exposure levels of everolimus (EVR) and tacrolimus (TAC) over 6 months.Renal transplant patients (N=613) were randomized…
  • 2016 American Transplant Congress

    Using Gastrointestinal Biopsy to Predict Outcome in Patients Evaluated for Cardiac Transplantation for Amyloidosis: A Report from the International Consortium on Cardiac Amyloidosis Transplantation (iCCAT).

    Y. Li,1 K. Verkouw,1 S. Tabtabai,1 R. Barrios,2 R. Gill,3 J. Koo,4 C. Marboe,5 E. Rodriguez,6 C. Tan,6 T. De Marco,3 J. Estep,2 M. Hanna,6 M. Maurer,5 J. Patel,4 V. Selby,3 M. Semigran,1 J. Stone.1

    1Massachusetts General Hospital, Boston, MA; 2The Methodist Hospital, Houston, TX; 3University of California San Francisco, San Francisco, CA; 4Cedars-Sinai Heart Institute, Los Angeles, CA; 5Columbia University Medical Center, New York, NY; 6Cleveland Clinic, Cleveland, OH.

    Heart transplant (HT) is an established therapy for heart failure due to amyloidosis. The utility of gastrointestinal (GI) biopsy in predicting patient outcomes and guiding…
  • 2016 American Transplant Congress

    Plasma Cell Frequency in Renal Rejection After Treatment with Alemtuzumab.

    L. Mugge, A. Zimmerman, N. Varshney, A. Gohara, M. Rees, J. Ortiz.

    Transplantation, The University of Toledo, Toledo, OH.

    Background: The highly successful induction drug Alemtuzumab (Campath) is commonly used prior to renal transplant. Yet, it does not completely ablate plasma cell which, in…
  • 2016 American Transplant Congress

    Don't Judge a Book by Its Cover: Normal Liver Enzymes After Transplantation Can Be Associated with Pathologies Requiring Intervention.

    C. Sanchez,1 S. Kumer,2 S. Olson,1 R. Gilroy,1 T. Schmitt,2 B. Kane,2 R. Taylor.1

    1Hepatology/Transplant, University of Kansas, Kansas City, KS; 2Surgery, University of Kansas, Kansas City, KS.

    Background:Liver biopsies are employed post-transplant generally to evaluate abnormal liver enzymes (LE); however they are not without risk. Whether post-transplant protocol biopsies (PB) serve any…
  • 2016 American Transplant Congress

    Digital Kidney Biopsy Evaluation: Quantification of Macrophage Prevalence in a Cross Sectional Study.

    J. Schmitz,1 A. Khalifa,1 H. Haller,2 H. Kreipe,1 F. Feuerhake,1 J. Bräsen.1

    1Institute of Pathology, Hannover Medical School, Hannover, Germany; 2Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

    Standardized markers based on quantitative and qualitative evaluation of immune cell mass and localization in kidney biopsies may help in diagnosis and prognosis in transplantation…
  • 2016 American Transplant Congress

    The Impact of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx) Is Independent of Time Post-Transplant.

    R. Gaston,1 J. Grande,2 R. Leduc,3 The DeKAF Study Group.

    1Dept. of Medicine, University of Alabama at Birmingham, Birmingham, AL; 2Dept of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; 3Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.

    Detection of MVI in a KTxBx, often associated with antibody mediated rejection, is associated with a poor prognosis for kidney graft survival. However most information…
  • 2015 American Transplant Congress

    Reduction of Tacrolimus With Everolimus Addition in Maintenance Immunosuppression Improves Calcineurin Inhibitor-Induced Arteriolopathy in Kidney Allografts

    M. Miura,1 H. Higashiyama,1 Y. Fukasawa.2

    1Department of Renal Transplant Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan; 2Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.

    Objectives: Although conversion of calcineurin inhibitor (CNI)-based immunosuppression to everolimus (EVR) has been shown to improve graft function, no histopathological evidence has been reported. The…
  • 2015 American Transplant Congress

    A Prospective Study of Renal Function and Histological Changes in Renal Transplant Recipients With Acute Clinical and Subclinical Rejection

    S. Chen,1 R. Mehta,1 P. Sood,1 P. Randhawa,2 N. Shah,1 C. Wu,1 A. Tevar,3 S. Hariharan.1

    1Nephrology, University of Pittsburgh Medical Center, Pittsburgh, PA; 2Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; 3Transplant Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

    Background: To study the impact on renal function and histological changes in patients(pts) with acute clinical rejection(ACR) and subclinical rejection(SCR) from 3 to 12 month(m)…
  • 2015 American Transplant Congress

    Association Between Histological Abnormalities in Time-Zero Renal Biopsies and Post-Donation eGFR in Live Donors

    L. Fahmy, A. Massie, B. Orandi, S. Bagnasco, J. Alejo, B. Boyarsky, S. Anjum, R. Montgomery, N. Dagher, D. Segev.

    Johns Hopkins, Baltimore.

    Time-zero biopsies (T0-RBx) of live-donor kidneys may reveal histological abnormalities at the time of organ recovery. The association between T0-RBx and subsequent kidney function in…
  • 2015 American Transplant Congress

    Deceased Donor and Class II Donor Specific Antibody Predict Interface Activity While Increased Age at Time of Biopsy Predicts Fibrosis in Long-Term Pediatric Liver Allografts With Normal Liver Tests: iWITH Clinical Trial

    S. Feng,1 J. Bucuvalas,2 A. Demetris,3 K. Spain,4 G. Mazariegos,3 B. Burrell,5 iWITH Investigators.6

    1UCSF, SF; 2U Cincinnati, Cincinnati; 3U Pittsburgh, Pittsburgh; 4Rho, Chapel Hill; 5ITN, Bethesda; 6NIAID/NIDDK/ITN, Bethesda.

    Background: Although multiple single centers have reported deterioration of pediatric liver grafts in the face of normal liver tests, neither risk nor mechanism is understood.Methods:…
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