ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histology"

  • 2016 American Transplant Congress

    Clinical, Histologic and Charge Endpoints When Populations with Hepatitis C Recurrence Are Treated with Direct-Acting Antiviral or Interferon Based Therapies.

    S. Olson, A. McCann, S. Kumer, T. Schmitt, B. Floyd, R. Taylor, R. Gilroy.

    University of Kansas, Kansas City, KS.

    Background: While the primary endpoint for patients transplanted for Hepatitis C (HCV) has been established as sustained virologic response (SVR), different pathways have existed to…
  • 2016 American Transplant Congress

    Complexity of Hylinosis in Renal Transplant Biopsies: Donor Age, Glomerular Disease, and Time.

    G. Einecke,1 J. Reeve,2 P. Halloran.2,3

    1Nephrology, Hannover Medical School, Hannover, Germany; 2Alberta Transplant Applied Genomics Centre, Edmonton, Canada; 3Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, Canada.

    Arteriolar hyalinosis lesions (ah) are often interpreted as a sign of calcineurin inhibitor toxicity even though they are induced by other conditions. We studied the…
  • 2016 American Transplant Congress

    The Treatment of Borderline Lesion in Protocol Biopsies Did Not Improve the Outcome in Kidney Transplant Recipients.

    A. Flores-Mendoza, L. Marino-Vazquez, A. Guichard-Romero, N. Uribe-Uribe, R. Rivera-Marfil, A. Nuñez-Abreu, J. Alberu, L. Morales-Buenrostro.

    Nephrology, Transplantation and Pathology, National Institute of Medical Sciences and Nutrition SZ, Mexico, Distrito Federal, Mexico.

    Introduction. Up to 30% of patients with protocol biopsies and stable renal function have borderline lesions. His relationship with acute rejection remains uncertain, as does…
  • 2016 American Transplant Congress

    Lower Renal Graft Function and Accelerated Fibrosis in HIV-Infected Transplant Recipients with Previous HIVAN Compared to Non HIVAN HIV-Positive Transplant Recipients.

    M.-N. Peraldi,1 H. Ayari,1 M. Burbach,1 C. Randoux,2 E. Pillebout,1 N. De Castro,3 J.-M. Molina,3 D. Glotz.1

    1Nephrologie et Transplantation, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France; 2Néphrologie, Hôpital Bichat et Université Paris-Diderot, Paris, France; 3Service de Maladies Infectieuses, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France.

    Several studies reported reduced renal allograft survival rates among HIV-infected transplant recipients. Few data focus on histological lesions and their progression in renal grafts from…
  • 2016 American Transplant Congress

    Everolimus with Low-Dose Tacrolimus vs. a Standard Immunosuppressive Regimen: Renal Histology at 6 Months in De Novo Renal Transplant Patients.

    S. Yilmaz,1 D. Shaffer,2 F. Shihab,3 K. McCague,4 D. Patel,4 Y. Qazi,5 F. Vincenti.6

    1University of Calgary, Calgary, AB, Canada; 2Vanderbilt University, Nashville, TN; 3University of Utah, Salt Lake City, UT; 4Novartis Pharmaceuticals Corporation, East Hanover, NJ; 5University of Southern California, Los Angeles, CA; 6University of California San Francisco, San Francisco, CA.

    Morphologic changes in transplant protocol biopsies provide early evidence of renal damage. This study examined the renal histology of de novo patients 6 months post…
  • 2016 American Transplant Congress

    Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection.

    A. Bodzin, Y. Becker, M. Josephson, P. Witkowski, M. Lockwood, L. Potter, B. Kane, L. Lourenco, J. Millis.

    Transplant Center, University of Chicago, Chicago, IL.

    Purpose: The negative impact of non-adherence to the immunosuppressant medication (IM) regimen on transplant outcomes is well recognized. In an attempt to improve outcomes, the…
  • 2015 American Transplant Congress

    Treatment of Subclinical Rejection Identified On Surveillance Biopsy May Prevent the Development of Chronic Alloimmune Injury

    M. Willicombe, C. Roufosse, J. Galliford, A. McLean, D. Taube.

    Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom.

    Surveillance biopsies [SBx] are not universally performed following renal transplantation. In patients in whom protocol biopsies are performed, how best to manage subclinical rejection [SCR]…
  • 2015 American Transplant Congress

    Post-Transplant Recurrence of Calcium Oxalate Crystals in Primary Hyperoxaluria Type 1 Detected by Surveillance Biopsies: Incidence, Risk Factors, and Effect on Graft Function

    L. Cornell, N. Pamidi, R. Mehta, M. Stegall, E. Lorenz, J. Heimbach, D. Milliner.

    Mayo Clinic, Rochester, MN.

    Background: Primary hyperoxaluria type 1 (PH1) is a rare metabolic defect that results in oxalate over-production by the liver and leads to renal disease due…
  • 2015 American Transplant Congress

    A New Diagnostic and Pronostic Tool for Antibody Mediated Rejection in Kidney Transplantation: Intragraft Donor Specific Anti-HLA Antibodies Detection

    J. Olagne,1,2,3 A. Parissiadis,2 S. Caillard,1 N. Froelich,2 L. Marcellin,3 C. Muller,1 G. Gautier-Vargas,1 P. Perrin,1 L. Braun-Parvez,1 F. Heibel,1 C. Gachet,2 B. Moulin.1

    1Service de Néphrologie - Transplantation, Centre Hospitalier Universitaire, Strasbourg, France; 2Laboratoire d'Histocompatibilité, Etablissement Français du Sang, Strasbourg, France; 3Département de Pathologie, Centre Hospitalier Universitaire, Strasbourg, France.

    INTRODUCTION: Antibody mediated rejection (AMR) is one of the main cause of loss of the kidney transplant. Despite the new BANFF classification, diagnostic difficulties and…
  • 2015 American Transplant Congress

    MYH9 Polymorphic Variants and Chronic Lesions in Transplanted Kidney Biopsy

    J. Pazik,1 M. Oldak,2 Z. Lewandowski,3 D. Ozieblo,4 K. Michalska,5 A. Perkowska Ptasińska,1 A. Sadowska,1 M. Nowaczyk,5 J. Malejczyk,4 M. Durlik.1

    1Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; 2Institute of Physiology and Pathology of Hearing, Warsaw, Poland; 3Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; 4Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; 5Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland.

    MYH9 encoding a non-muscle myosin heavy chain IIA is expressed in podocytes, mesangial, tubular, capillary endothelial cells and vascular wall. Intronic variants of MYH9 associate…
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