2016 American Transplant Congress
Anti-HLA Antibodies in Allogeneic and Autologous Hematopoietic Stem Cell Transplantation.
Introduction: Anti-HLA antibodies have been associated with graft rejection in solid organ and hematopoietic stem cell transplantation (HSCT). The aim of this study was describe…2016 American Transplant Congress
Optimized Flow Cytometry Crossmatch with Increased Sensitivity and Specificity.
The flow cytometry crossmatch (FCXM) is the standard method to prevent hyperacute rejection after transplantation. Surprisingly, few technical improvements have been introduced to the FCXM…2016 American Transplant Congress
Optimizing CPRAs for Sensitized Kidney Waitlist Candidates: The Devil Is in the KAS Details.
The new kidney allocation system (KAS) has increased transplant rates for highly sensitized candidates. We hypothesized that increasing unacceptable antigens to transition candidates from 80-98%…2015 American Transplant Congress
HLA-Cw Mismatches Are Not Associated With Worse Graft Outcomes After Kidney Transplantation Even in High Levels of Antigen Expression
1Cleveland Clinic, Cleveland; 2University of Alexandria, Alexandria, Egypt.
The HLA-Cw antigens are distinct in having relatively lower expression on the cell surface compared to the other HLA class I loci. Higher HLA Cw…2015 American Transplant Congress
Clinical Relevance of C3d-Binding Donor-Specific Antibodies in Late Kidney Allograft Failure
Background: The objective of this study was to investigate the prognostic value of C3d-binding donor-specific antibodies (DSA) in determining late kidney allograft failure.Methods: 1048 patients…2015 American Transplant Congress
Number of Antigen Targets: A Key Parameter for Accurate Flow Cytometry Crossmatch Interpretation of Weak DSA
BACKGROUND: Flow cytometry crossmatch (FCXM) results are used to assess the safety of a transplant across pre-existing DSA. The number of targets on donor cells…2015 American Transplant Congress
Human Hematopoietic Chimeric Cells as a Novel Approach for Tolerance Induction After Transplantation
Background: Cellular therapies represent a new promising approach for transplant tolerance induction. One of the methods for immune response modulation in solid organ and vascularized…2015 American Transplant Congress
Kidney Paired Donation: National Activity and Perspectives
While utilization of Kidney Paired Donation (KPD) continues to increase, the potential is not fully realized. We surveyed kidney transplant (KTX) professionals to evaluate perceptions…2015 American Transplant Congress
Improving the Predictive Value of the Virtual Crossmatch: Is the C1Q Assay Needed?
The criteria for reporting unacceptable HLA antigens of renal transplant candidates differ greatly between transplant centers. In the attempt to refine these criteria, the experience…2015 American Transplant Congress
HLA-C, KIR Genotypes and KIR Genotype/HLA –C Ligand Combination in Prediction of Early Acute Rejection After Liver Transplantation
Introduction; Interaction of killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen class-I (HLA-I) regulates NK cytotoxicity and function. NK regulation influences on NK/T cell alloreactivity…
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