2022 American Transplant Congress
Site-Directed Mutagenesis as a Tool to Investigate Immunogenicity of HLA Epitopes for Humoral Alloreactivity
1Northwestern University, Chicago, IL, 2University Hospital Essen, Essen, Germany
*Purpose: Molecular mismatch load (MML) analysis has been a proposed approach to assess donor/recipient compatibility in support of organ allocation algorithms. While conceptually appealing, MML…2022 American Transplant Congress
Histocompatibility Findings in the First Xenotransplants from a Pig to Deceased Human Recipient
Transplant Institute, NYU Langone Transplant Institute, New York, NY
*Purpose: Humans lack α-1,3-Gal (α-gal) epitopes, and naturally occurring α-gal antibodies (Abs) cause hyperacute rejection of porcine xenografts. We conducted 2 successful xenotransplants in brain-dead…2022 American Transplant Congress
HLA DSA May Not Be Detected in Many Solid Organ Recipients
1Keck School of Medicine, Los Angeles, CA, 2Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: Clinically significant HLA antibodies may not be detected if their unique HLA epitopes are not represented in the single antigen reagents that are routinely…2022 American Transplant Congress
A Novel Application of SRTR Data to Interrogate the Effects of HLA-DQ Mismatches in Kidney Transplantation
*Purpose: Single-center studies demonstrate de-novo HLA-DQ donor-specific antibodies (DSA) are the most common and pathogenic DSA. However, HLA-DQ is not accounted for in many kidney…2022 American Transplant Congress
Which is More Important for Predicting De Novo DSA Production, B Cell Epitope (EPLET) or T Cell Epitope (PIRCHE) Analysis ?
*Purpose: De novo donor-specific antibodies (dnDSA) can cause chronic ABMR, resulting in poor prognosis. Recently, mismatch at B cell epitope level, i.e. EPLET mismatch, has…2021 American Transplant Congress
Disparities in HLA Representation by Single Antigen Reagents in Different Ethnic Populations
1Keck School of Medicine of USC, Los Angeles, CA, 2Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: It is not possible to test for antibodies against the antigens encoded by every HLA allele due to cost and throughput constraints. When alleles…2021 American Transplant Congress
HLA Mismatching and Subclinical Inflammation: An Association to be Considered in Kidney Transplant Patients with Low Immunological Risk
*Purpose: Subclinical inflammation (SCI) (2021 American Transplant Congress
The Co-Occurrence of Newly Developed HLA Donor Specific Antibody and Positive C3d/C4d Profiles Along with Immune Therapy Non-Compliance in Pediatric Heart Transplant Recipients is a High Risk Indicator for Patient Mortality
Cleveland Clinic Foundation Transplant Center, Cleveland, OH
*Purpose: Increasing evidence has implicated the deleterious effect of HLA donor specific antibody (DSA) in pediatric heart transplantation (PHTx). However, there are still insufficient research…2021 American Transplant Congress
Influence of HLA Compatibility on Bk Virus Associated Nephropathy Among Japanese Living Donor Kidney Transplant Recipients
*Purpose: BK polyomavirus-associated nephropathy (BKVN) after kidney transplantation is associated with a high morbidity and higher risk of graft loss. In this study, the relationship…2021 American Transplant Congress
HLA Haplotype Frequency and Racial Disparities in Access to Transplant Among Highly Sensitized Kidney Transplant Candidates
*Purpose: Despite implementation of the Kidney Allocation System (KAS) which prioritizes sensitized patients, sensitized Black individuals are less likely to receive a transplant than non-Black…
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