Articles tagged "Histocompatibility"

2022 American Transplant Congress
HLA DSA May Not Be Detected in Many Solid Organ Recipients
J. C. Quon¹, R. M. Lestz², J. Menteer², N. Fotiadis², L. A. Baxter-Lowe²
¹Keck School of Medicine, Los Angeles, CA, ²Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: Clinically significant HLA antibodies may not be detected if their unique HLA epitopes are not represented in the single antigen reagents that are routinely…
2022 American Transplant Congress
A Novel Application of SRTR Data to Interrogate the Effects of HLA-DQ Mismatches in Kidney Transplantation
D. Isaacson¹, M. W. Gmeiner², V. Kosmoliaptsis³, H. C. Copley³, J. D. Schold⁴, A. R. Tambur¹
¹Northwestern University, Chicago, IL, ²London School of Economics, London, United Kingdom, ³Cambridge University, Cambridge, United Kingdom, ⁴Cleveland Clinic, Cleveland, OH
*Purpose: Single-center studies demonstrate de-novo HLA-DQ donor-specific antibodies (DSA) are the most common and pathogenic DSA. However, HLA-DQ is not accounted for in many kidney…
2022 American Transplant Congress
Which is More Important for Predicting De Novo DSA Production, B Cell Epitope (EPLET) or T Cell Epitope (PIRCHE) Analysis ?
T. Kobayashi¹, T. Tomosugi², S. Sakamoto², S. Ashimine¹, K. Iwasaki¹, M. Niemann³, E. Spierings⁴, Y. Miwa¹, M. Okumura¹, K. Ishiyama¹, A. Takeda², N. Goto², S. Narumi², Y. Watarai²
¹Aichi Medical University School of Medicine, Nagakute, Japan, ²Nagoya Daini Red Cross Hospital, Nagoya, Japan, ³PIRCHE AG, Berlin, Germany, ⁴UMC Utrecht, Utrecht, Netherlands
*Purpose: De novo donor-specific antibodies (dnDSA) can cause chronic ABMR, resulting in poor prognosis. Recently, mismatch at B cell epitope level, i.e. EPLET mismatch, has…
2022 American Transplant Congress
Long-Term Outcomes of Crossmatch Positive Simultaneous Liver Kidney Transplants in the United States
S. Riad¹, E. Aby¹, S. Jackson², P. Nguyen³, N. Lim¹, J. Lake¹
¹Medicine, University of Minnesota, Minneapolis, MN, ²Mhealth-Fairview, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: The long-term results of crossmatch positive (XM+) simultaneous liver-kidney (SLK) transplants are conflicting. We examined the association between crossmatch (XM) status and SLK outcomes…
2022 American Transplant Congress
Simultaneous Liver/ Kidney Transplant Reduces Both Donor Specific and Non-Donor Specific HLA Antibodies
X. Zhang, S. Wisel, I. Kim, S. Jordan
Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Kidney allografts can be transplanted across strong donor specific antibody (DSA) barriers in simultaneous liver/kidney transplant (SLK) recipients. It is suggested that preformed DSAs…
2021 American Transplant Congress
The Co-Occurrence of Newly Developed HLA Donor Specific Antibody and Positive C3d/C4d Profiles Along with Immune Therapy Non-Compliance in Pediatric Heart Transplant Recipients is a High Risk Indicator for Patient Mortality
A. Zhang, C. Nasman, J. Allen, Y. Sun, D. Thomas, R. Rodriguez, C. Tan, G. Boyle
Cleveland Clinic Foundation Transplant Center, Cleveland, OH
*Purpose: Increasing evidence has implicated the deleterious effect of HLA donor specific antibody (DSA) in pediatric heart transplantation (PHTx). However, there are still insufficient research…
2021 American Transplant Congress
Influence of HLA Compatibility on Bk Virus Associated Nephropathy Among Japanese Living Donor Kidney Transplant Recipients
N. Fujiyama¹, M. Saito², R. Yamamoto², R. Sagehashi², T. Saito², S. Kashima², K. Numakura², S. Narita², T. Habuchi², S. Satoh¹
¹Center for Kidney Disease and Transplantaion, Akita University Hospital, Akita, Japan, ²Department of Urology, Akita University Graduate School of Medicine, Akita, Japan
*Purpose: BK polyomavirus-associated nephropathy (BKVN) after kidney transplantation is associated with a high morbidity and higher risk of graft loss. In this study, the relationship…
2021 American Transplant Congress
HLA Haplotype Frequency and Racial Disparities in Access to Transplant Among Highly Sensitized Kidney Transplant Candidates
L. Gragert¹, M. Kadatz², D. Chang², H. Gebel³, D. Stewart⁴, E. Kransdorf⁵, S. Brar², S. Vaishnav², J. Gill², J. Lan²
¹Tulane University, New Orleans, LA, ²University of British Columbia, Vancouver, BC, Canada, ³Emory University, Atlanta, GA, ⁴UNOS, Richmond, VA, ⁵Cedars-Sinai, Beverly Hills, CA, Canada
*Purpose: Despite implementation of the Kidney Allocation System (KAS) which prioritizes sensitized patients, sensitized Black individuals are less likely to receive a transplant than non-Black…
2021 American Transplant Congress
Is Equitable Access to Transplantation Possible in the Era of HLA Epitope Compatibility?
S. Parto¹, J. Lamsatfi², B. Liu², A. Bourdiec², B. Foster², K. Oualkacha², F. Claas³, P. Keown⁴, R. Sapir-Pichhadze⁵
¹Medicine, McGill University, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada, ³Leiden University Medical Centre, Albinusdreef, Netherlands, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵Medicine, McGill University Health Centre, Montreal, QC, Canada
*Purpose: We applied the calculated Panel of Incompatible Epitopes (cPIE), an algorithm informing on the likelihood of identifying blood group and eplet-compatible donors, to study…
2021 American Transplant Congress
Dynamics of IgG Subclass as a Mechanism of Desensitization Using Rituximab for Presensitized Patients Undergoing Living Related Liver Transplantation
H. Egawa¹, K. Ide², T. Ishizuka³, H. Ohdan⁴, Y. Kotera¹, T. Kato¹, A. Ohmori¹, Y. Hirata¹, G. Shibuya¹, S. Yamashita¹, S. Ariizumi¹
¹Tokyo Women's Medical University, Tokyo, Japan, ²Surgery, Hiroshima University, Hiroshima, Japan, ³Clinical Laboratory, Tokyo Women's Medical University, Tokyo, Japan, ⁴Hiroshima University, Hiroshima, Japan
*Purpose: Although impact of preformed HLA-related donor specific antibody (DSA) and necessity of desensitization in liver transplantation (LT) has been recognized, mechanisms of desensitization in…