Articles tagged "Histocompatibility"

2022 American Transplant Congress
Simultaneous Liver/ Kidney Transplant Reduces Both Donor Specific and Non-Donor Specific HLA Antibodies
X. Zhang, S. Wisel, I. Kim, S. Jordan
Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Kidney allografts can be transplanted across strong donor specific antibody (DSA) barriers in simultaneous liver/kidney transplant (SLK) recipients. It is suggested that preformed DSAs…
2022 American Transplant Congress
Complete and High-Resolution HLA Typing Improves the Accuracy of Post-Transplant Assessment of De Novo Anti-Donor Immune-Mediated Events
M. Meneghini¹, A. Perona², E. Crespo³, F. J. Bemelman⁴, P. M. Reinke⁵, O. Viklicky⁶, M. Giral⁷, O. Bestard¹
¹Vall d'Hebron University Hospital, Barcelona, Spain, ²Universitat de Barcelona, Barcelona, Spain, ³Nephrology and Transplantation Laboratory, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, ⁴Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁵Charité Universitätsmedizin, Berlin, Germany, ⁶Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, ⁷Nantes Université, Inserm, CHU Nantes, Nantes, France
*Purpose: High-resolution (HR) HLA typing using NGS technology has shown to improve the accuracy of assessing donor-recipient compatibility and characterization of pre-transplant anti HLA antibodies…
2022 American Transplant Congress
High Resolution Typing Can Improve Accuracy and Sensitivity of the Virtual Crossmatch for Sensitized Patients – A Single Center’s Experience
C. MarElia-Bennett¹, V. Rohan², K. Twombley³, O. Moussa¹
¹Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, ²Surgery, Medical University of South Carolina, Charleston, SC, ³Medical University of South Carolina, Charleston, SC
*Purpose: The introduction of solid phase assays has significantly enhanced our ability to execute virtual crossmatches (VXMs). However, this method is not without its shortcomings.…
2022 American Transplant Congress
ABO Hemagglutination Titres Do Not Accurately Reflect ABO Antibody Levels
A. Halpin¹, T. Ellis², J. Pearcey², B. Motyka², T. L. Lowary³, C. Cairo⁴, S. Maier², L. J. West⁵
¹Pediatrics/Dept of Laboratory Medicine, University of Alberta/Alberta Precision Laboratories, Edmonton, AB, Canada, ²Pediatrics, University of Alberta, Edmonton, AB, Canada, ³Academia Sinica, Institute of Biological Chemistry, Taipei, Taiwan, ⁴Chemistry, University of Alberta, Edmonton, AB, Canada, ⁵Pediatrics, University of Alberta, Canadian Donation and Transplant Research Program, Edmonton, AB, Canada
*Purpose: ABO antibody (ABO-Ab) quantification is essential for risk assessment for ABO-incompatible (ABOi) transplantation, but the hemagglutination assay (HA) for ABO-Ab titres is known to…
2022 American Transplant Congress
Beyond CPRA: Identifying Sensitized Kidney Candidates with Markedly Low Access to Transplant
K. Bradbrook¹, A. Maldonado², K. Sjöholm², C. Kjellman², J. Lee³, D. Stewart¹
¹UNOS, Richmond, VA, ²Hansa Biopharma AB, Lund, Sweden, ³Immucor, Norcross, GA
*Purpose: The Kidney Allocation System (KAS) improved the rates of transplantation in highly sensitized (HS) patients. However, a subset of HS patients remain at a…
2021 American Transplant Congress
Dynamics of IgG Subclass as a Mechanism of Desensitization Using Rituximab for Presensitized Patients Undergoing Living Related Liver Transplantation
H. Egawa¹, K. Ide², T. Ishizuka³, H. Ohdan⁴, Y. Kotera¹, T. Kato¹, A. Ohmori¹, Y. Hirata¹, G. Shibuya¹, S. Yamashita¹, S. Ariizumi¹
¹Tokyo Women's Medical University, Tokyo, Japan, ²Surgery, Hiroshima University, Hiroshima, Japan, ³Clinical Laboratory, Tokyo Women's Medical University, Tokyo, Japan, ⁴Hiroshima University, Hiroshima, Japan
*Purpose: Although impact of preformed HLA-related donor specific antibody (DSA) and necessity of desensitization in liver transplantation (LT) has been recognized, mechanisms of desensitization in…
2021 American Transplant Congress
Post-Transplant Outcomes Comparing A2 Incompatible to Compatible Deceased Donor Liver Transplant Recipients
T. Chiang, M. A. Eagleson, S. Bae, J. Garonzik-Wang, D. Segev, A. B. Massie
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Transplantation of A2 livers into type O and B recipients (A2i DDLT) is a growing modality to increase access to DDLT for O and…
2021 American Transplant Congress
The Calculated Panel of Incompatible Epitopes (cPIE) in the Service of Equitable Access to Transplantation
J. Lamsatfi¹, B. Bingfan Liu¹, S. Parto², A. Lewin³, K. Oualkacha¹, F. Claas⁴, P. Keown⁵, R. Sapir-Pichhadze⁶
¹McGill University, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³Hema-Quebec, Montreal, QC, Canada, ⁴Leiden University Medical Centre, Albinusdreef, Netherlands, ⁵University of British Columbia, Vancouver, BC, Canada, ⁶Medicine, McGill University Health Centre, Montreal, QC, Canada
*Purpose: To inform on feasibility of eplet matching, we developed the calculated Panel of Incompatible Epitopes (cPIE), an algorithm informing on the likelihood of identifying…
2021 American Transplant Congress
Blood Type A2/a2b to B Renal Transplantation: A Single Center Retrospective Cohort Study
V. S. Tatapudi, N. Alnazari, R. Chand, N. M. Ali, B. E. Lonze, R. A. Montgomery
NYU Langone Transplant Institute, NYU Langone Health, New York, NY
*Purpose: Blood type B candidates on the deceased donor kidney waitlist have a lower transplantation rate and longer wait time than candidates of other blood…
2021 American Transplant Congress
Use of a Novel Bead-based Assay to Measure the Impact of Imlifidase on ABO IgG Antibodies
A. Halpin¹, B. Motyka², T. Ellis², J. Pearcey², T. L. Lowary³, A. Runström⁴, L. Winstedt⁴, R. Bockermann⁴, S. Järnum⁴, A. Robertson⁴, L. J. West⁵
¹Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta and Alberta Precision Laboratories, Edmonton, AB, Canada, ²Department of Pediatrics, University of Alberta, Edmonton, AB, Canada, ³Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ⁴Hansa Biopharma, Lund, Sweden, ⁵Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: The accurate assessment and measurement of ABO antibodies (ABO-Ab) is a critical component of ABO-incompatible (ABOi) transplantation. ABO-Ab comprise both IgG and IgM, which…