ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histocompatibility antigens"

  • 2020 American Transplant Congress

    MHC II-Decoy Car-T Cells to Induce Long-Term Allotransplant Organ Tolerance

    W. McCall1, T. Baybutt1, A. Snook1, A. Shah2

    1Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Philadelphia, PA, 2Department of Surgery, Division of Transplantation, Sidney Kimmel Medical College, Philadelphia, PA

    *Purpose: Allotransplantation represents the definitive therapy for end-stage renal, heart, liver, and lung disease. Current immunosuppressive regimens fail to promote long-term engraftment, leading to chronic…
  • 2020 American Transplant Congress

    Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk

    W. S. Oetting1, G. Weihua1, C. R. Dorr1, R. B. Mannon2, A. J. Matas1, P. A. Jacobson1, A. K. Israni1

    1University of Minnesota, Minneapolis, MN, 2University of Alabama, Birmingham, AL

    *Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…
  • 2019 American Transplant Congress

    Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates

    H. Sweiss1, J. Lyons1, D. Ranch2, K. Hitchman2, E. Kincaide1, B. Crowther1

    1University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 2University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX

    *Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…
  • 2019 American Transplant Congress

    Predicted Indirectly Recognizable H L A Epitopes Are Associated with T-cell Mediated Rejection among Kidney Transplant Recipients with Preformed and De Novo Donor-Reactive T-cells

    T. Schachtner1, M. Stein2, N. M. Otto3, P. M. Reinke2

    1Nephrology, University Hospital Zurich, Zurich, Switzerland, 2Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany, 3Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berin, Germany

    *Purpose: Very recently Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) have been suggested to demonstrate early and late effects on kidney allograft outcomes. The association between…
  • 2019 American Transplant Congress

    Non-HLA Antibodies against Structural and Non-Structural Target in C4d Negative Antibody Mediated Rejections after Renal Transplantation

    S. Kanangat1, I. Kurbegovic-Skaljic2, D. Cimbaluk2, M. Oppermann2, S. Jensik3, E. Hollinger3, O. Olaitan4, R. DeCresce2

    1Tumor Immunology, NIH/NCI Bethesda MD,USA, Bethesda, MD, 2Pathology, Rush University Medical Center, Chicago, IL, 3Surgery, Rush University Medical Center, Chicago, IL, 4Tumor Immunology, Rush University Medical Center, Chicago, IL

    *Purpose: According to the latest Banff’s criteria approved in 2003, antibody mediated rejections following renal transplantation are divided into 2 types namely C4d + and…
  • 2019 American Transplant Congress

    Desensitization Using Only IVIG: Is That an Option for Highly-Sensitized Patients Waiting for Kidneys from Cadaveric Donors?

    J. O. Paixão, L. R. Ulisses, P. S. Souza, G. Bezerra, F. Agena, H. P. Rodrgues, N. Panajotopoulos, F. J. Paula, E. David-Neto, M. R. Castro

    Nefrologia, Hospital das Clínicas da Universidade de São Paulo, São Paulo, Brazil

    *Purpose: The reduction of anti-HLA has been proven to be efficient and safe in transplants of highly-sensitized with living donors (LD). The results of adopting…
  • 2019 American Transplant Congress

    Towards Human Leukocyte Antigen Immunogenicity Assessment at the Individual Patient Level

    H. Copley1, H. McDowell2, D. Pinelli2, A. R. Tambur2, V. Kosmoliaptsis1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom, 2Department of Surgery, Feinberg School of Medicine, Comprehensive Transplant Center, Northwestern University, Chicago, IL

    *Purpose: Allorecognition of donor HLA and induction of humoral alloimmunity is a major cause of graft loss after solid-organ transplantation. Current approaches to study molecular…
  • 2018 American Transplant Congress

    The Impact of Duration on Dialysis on the Pre-Transplant Allosensitization According to Panel Reactive Antibody Levels

    Y. Jung,1 D. Kim,1 J. Lee,1 S. Song,2 J. Lee,3 B. Kim,4 J. Lee,1 S. Kim,1 M. Kim,1 S. Kim,1 Y. Kim,1 K. Huh.1

    1Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Department of Surgery, College of Medicine, Ewha Women's University, Seoul, Republic of Korea; 3Department of Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea; 4Departments of Nephrology, Yonsei University College of Medicine, Seoul, Republic of Korea.

    Purpose : Presensitization to human leukocyte antigen(HLA) is one of the most important barriers to overcome in the field of renal transplantation. Due to the…
  • 2018 American Transplant Congress

    Selection and Stratification of Anti-HLA-A and HLA-B Sensitized Patients in Pig-to-Human Xenotransplantation

    G. Martens,1 J. Ladowski,1 J. Butler,2 L. Reyes,1 M. Tector,1 A. Tector.1

    1University of Alabama at Birmingham, Birmingham, AL; 2Indiana University School of Medicine, Indianapolis, IN.

    Introduction: Patients with anti-HLA-A and –B antibodies are difficult to match and represent a possible population for inclusion in pig-to-human xenotransplantation clinical trials. Donor specific…
  • 2018 American Transplant Congress

    Generation of Calculated Panel-Reactive Antibody Values Using a Reference Panel of Bone Marrow Donors

    E. Kransdorf,1 L. Gragert,2,4 M. Pando,3 N. Kaur,2 J. Patel,1 I. Kim,1 X. Zhang,1 M. Maiers,4 J. Kobashigawa.1

    1Cedars-Sinai Medical Center, Los Angeles, CA; 2Tulane University School of Medicine, New Orleans, LA; 3Baylor Scott & White, Temple, TX; 4National Marrow Donor Program, Minneapolis, MN.

    Introduction: Calculated panel-reactive antibody (CPRA) is the official metric of sensitization used by the United Network for Organ Sharing (UNOS) for kidney allocation. The reference…
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