ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histocompatibility antigens"

  • 2020 American Transplant Congress

    The Impact of HLA-DQ Molecular Mismatches on De Novo Occurrence of Donor-Specific Anti-HLA Antibodies after Kidney Transplantation: An Observational Cohort Study

    A. Senev1, M. Coemans1, V. Van Sandt2, E. Van Loon1, J. Callemeyn1, B. Sprangers1, D. Kuypers1, M. Emonds1, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2HILA, Red Cross-Flanders, Mechelen, Belgium

    *Purpose: Evaluating HLA molecular mismatches (MM) instead of antigen mismatches might be a better tool to assess donor-recipient HLA incompatibility and provide a better risk…
  • 2020 American Transplant Congress

    Low HLA Class I Epitope Mismatch Associated with Improved Pancreas Graft Survival in Simultaneous Pancreas-Kidney Transplantation

    J. M. Ladowski, M. Romine, D. Kloda, C. Young, J. Locke, V. Hauptfeld-Dolejsek, J. Houp

    University of Alabama-Birmingham, Birmingham, AL

    *Purpose: Antibody-mediated rejection remains the principal cause of allotransplant graft failure. Human leukocyte antigen (HLA) matching between donor and recipients significantly reduces the risk of…
  • 2019 American Transplant Congress

    Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates

    H. Sweiss1, J. Lyons1, D. Ranch2, K. Hitchman2, E. Kincaide1, B. Crowther1

    1University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 2University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX

    *Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…
  • 2019 American Transplant Congress

    Predicted Indirectly Recognizable H L A Epitopes Are Associated with T-cell Mediated Rejection among Kidney Transplant Recipients with Preformed and De Novo Donor-Reactive T-cells

    T. Schachtner1, M. Stein2, N. M. Otto3, P. M. Reinke2

    1Nephrology, University Hospital Zurich, Zurich, Switzerland, 2Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany, 3Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berin, Germany

    *Purpose: Very recently Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) have been suggested to demonstrate early and late effects on kidney allograft outcomes. The association between…
  • 2019 American Transplant Congress

    Non-HLA Antibodies against Structural and Non-Structural Target in C4d Negative Antibody Mediated Rejections after Renal Transplantation

    S. Kanangat1, I. Kurbegovic-Skaljic2, D. Cimbaluk2, M. Oppermann2, S. Jensik3, E. Hollinger3, O. Olaitan4, R. DeCresce2

    1Tumor Immunology, NIH/NCI Bethesda MD,USA, Bethesda, MD, 2Pathology, Rush University Medical Center, Chicago, IL, 3Surgery, Rush University Medical Center, Chicago, IL, 4Tumor Immunology, Rush University Medical Center, Chicago, IL

    *Purpose: According to the latest Banff’s criteria approved in 2003, antibody mediated rejections following renal transplantation are divided into 2 types namely C4d + and…
  • 2019 American Transplant Congress

    Desensitization Using Only IVIG: Is That an Option for Highly-Sensitized Patients Waiting for Kidneys from Cadaveric Donors?

    J. O. Paixão, L. R. Ulisses, P. S. Souza, G. Bezerra, F. Agena, H. P. Rodrgues, N. Panajotopoulos, F. J. Paula, E. David-Neto, M. R. Castro

    Nefrologia, Hospital das Clínicas da Universidade de São Paulo, São Paulo, Brazil

    *Purpose: The reduction of anti-HLA has been proven to be efficient and safe in transplants of highly-sensitized with living donors (LD). The results of adopting…
  • 2019 American Transplant Congress

    Towards Human Leukocyte Antigen Immunogenicity Assessment at the Individual Patient Level

    H. Copley1, H. McDowell2, D. Pinelli2, A. R. Tambur2, V. Kosmoliaptsis1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom, 2Department of Surgery, Feinberg School of Medicine, Comprehensive Transplant Center, Northwestern University, Chicago, IL

    *Purpose: Allorecognition of donor HLA and induction of humoral alloimmunity is a major cause of graft loss after solid-organ transplantation. Current approaches to study molecular…
  • 2018 American Transplant Congress

    Selection and Stratification of Anti-HLA-A and HLA-B Sensitized Patients in Pig-to-Human Xenotransplantation

    G. Martens,1 J. Ladowski,1 J. Butler,2 L. Reyes,1 M. Tector,1 A. Tector.1

    1University of Alabama at Birmingham, Birmingham, AL; 2Indiana University School of Medicine, Indianapolis, IN.

    Introduction: Patients with anti-HLA-A and –B antibodies are difficult to match and represent a possible population for inclusion in pig-to-human xenotransplantation clinical trials. Donor specific…
  • 2018 American Transplant Congress

    Generation of Calculated Panel-Reactive Antibody Values Using a Reference Panel of Bone Marrow Donors

    E. Kransdorf,1 L. Gragert,2,4 M. Pando,3 N. Kaur,2 J. Patel,1 I. Kim,1 X. Zhang,1 M. Maiers,4 J. Kobashigawa.1

    1Cedars-Sinai Medical Center, Los Angeles, CA; 2Tulane University School of Medicine, New Orleans, LA; 3Baylor Scott & White, Temple, TX; 4National Marrow Donor Program, Minneapolis, MN.

    Introduction: Calculated panel-reactive antibody (CPRA) is the official metric of sensitization used by the United Network for Organ Sharing (UNOS) for kidney allocation. The reference…
  • 2018 American Transplant Congress

    Correlation of Kidney Transplant Human Leukocyte Antigen Eplet Mismatching to De Novo Donor Specific Antibody Production and Post-Transplant Outcomes

    R. Samudralwar,1 K. Szempruch,1 C. Reuter,3 B. Franz,4 R. Lee,1 E. Weimer,4 R. Detwiler,2 T. Kozlowski,2 J. Schmitz.4

    1Department of Pharmacy, Universitty of North Carolina Medical Center, Chapel Hill, NC; 2Department of Surgery, Universitty of North Carolina Medical Center, Chapel Hill, NC; 3Department of Pharmacy, Ochsner Health System, New Orleans, LA; 4Department of Pathology, University of North Carolina Medical Center, Chapel Hill, NC.

    Human Leukocyte Antigen (HLA) eplet mismatches (EMM) are associated with the development of de novo donor specific antibody (dnDSA) in kidney transplant recipients (KTRs). There…
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