ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

The Impact of Duration on Dialysis on the Pre-Transplant Allosensitization According to Panel Reactive Antibody Levels

Y. Jung,1 D. Kim,1 J. Lee,1 S. Song,2 J. Lee,3 B. Kim,4 J. Lee,1 S. Kim,1 M. Kim,1 S. Kim,1 Y. Kim,1 K. Huh.1

1Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea
2Department of Surgery, College of Medicine, Ewha Women's University, Seoul, Republic of Korea
3Department of Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
4Departments of Nephrology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Meeting: 2018 American Transplant Congress

Abstract number: C138

Keywords: Alloantibodies, Antibodies, Histocompatibility antigens, Risk factors

Session Information

Date: Monday, June 4, 2018

Session Name: Poster Session C: Kidney Living Donor Issues

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Related Abstracts
  • Impact of Pre-Transplant Panel Reactive Antibody Levels On Renal Graft Survival in Patients With Negative Cross-Match and No Donor Specific Antibody
  • Impact of Immunosuppression Maintenance after Failed Kidney Transplant on Panel Reactive Antibody (PRA) for Retransplantation, a Single Center Experience

Purpose : Presensitization to human leukocyte antigen(HLA) is one of the most important barriers to overcome in the field of renal transplantation. Due to the development of the techniques in dialysis as well as the organ shortage, the number of patients in the waiting list and their duration on dialysis have been increasing and the risk for sensitization rises as well. Hence, the purpose of our study was to investigate the relationship between the duration on dialysis and panel reactive antibody(PRA) score as the indicator for allosensitization.

Methods : A total of 1196 patients who underwent renal allograft between 2008 to 2015 were included. The patient information on the dialysis history, the duration on dialysis (pre-emptive, <5 or ≥5 years), history for transfusion, pregnancy, and prior transplantation were collected retrospectively, to find their effects on pre-transplant PRA score. The PRA score is expressed as a percentage between 0% and 100%, which represents the presence of class-I or II anti-HLA antibodies (class-I or II PRA positivity). Univariate and multivariate analyses were performed to find significant factors related to PRA score.

Results : In the univariate analysis, class-I PRA positivity was significantly related to the increased duration on dialysis, as well as the previous histories for pregnancy and transplantation. For class-II PRA positivity, univariate analysis showed positive correlations of PRA score to increased duration on dialysis, the previous history for transfusion, pregnancy, and prior transplantation. In multivariate analysis, increased dialysis duration was strongly related to class-I PRA positivity (HR 3.6, 95% CI 1.8-5.4, p<0.001) and class-II PRA positivity (HR 2.8, 95% CI 1.0-4.5, p=0.002) as well as previous history of transplantation. Dialysis duration was significantly related to PRA score in both class-I and class-II PRA positivity.

Conclusions : In end-stage renal disease patients, as the duration on dialysis increases, the risk for allosensitization to HLA rises, as shown in PRA score.

CITATION INFORMATION: Jung Y., Kim D., Lee J., Song S., Lee J., Kim B., Lee J., Kim S., Kim M., Kim S., Kim Y., Huh K. The Impact of Duration on Dialysis on the Pre-Transplant Allosensitization According to Panel Reactive Antibody Levels Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Jung Y, Kim D, Lee J, Song S, Lee J, Kim B, Lee J, Kim S, Kim M, Kim S, Kim Y, Huh K. The Impact of Duration on Dialysis on the Pre-Transplant Allosensitization According to Panel Reactive Antibody Levels [abstract]. https://atcmeetingabstracts.com/abstract/the-impact-of-duration-on-dialysis-on-the-pre-transplant-allosensitization-according-to-panel-reactive-antibody-levels/. Accessed March 8, 2021.

« Back to 2018 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.