ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histocompatibility antigens"

  • 2022 American Transplant Congress

    The Impact of Soluble Human Leukocyte Antigen (HLA) on Renal Antibody-Mediated Rejection (AMR) After Simultaneous Liver Kidney Transplantation (SLKT)

    H. Me1, A. Jaramillo1, D. Ramon1, L. G. Olsen1, R. Heilman1, H. Khamash1, T. Mohanakumar2, R. Ravichandran2

    1Mayo Clinic, Phoenix, AZ, 2St. Joseph's Hospital and Medical Center, Phoenix, AZ

    *Purpose: The lower incidence of AMR and higher incidence of rejection-free grafts survival in SLKT recipients as compared to kidney transplant recipients have been clearly…
  • 2022 American Transplant Congress

    Use of Pronase to Identify HLA Crossmatch Antibody Interference

    N. Hendren1, C. Lacelle1, S. Carter1, J. L. Grodin1, E. Hardin2, M. Farr3, S. Garg1

    1UT Southwestern, Dallas, TX, 2University of Texas Southwestern Medical Center, Dallas, TX, 3University of Texas Southwestern, Dallas, TX

    *Purpose: Solid organ transplant centers should maintain vigilance that antibody therapies can impact HLA crossmatch results.*Methods: N/A*Results: A 46-year-old man with Mayo stage IV cardiac…
  • 2021 American Transplant Congress

    The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation

    A. Senev, E. Van Loon, M. Emonds, M. Naesens

    Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium

    *Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…
  • 2021 American Transplant Congress

    Precision Medicine in Renal Transplantation: Structural Biology of HLA Defines Allelic Binding of Cardinal Pathogenic Viruses in Transplantation

    K. R. Sherwood1, A. Nguyen2, J. Tran1, O. Gunther3, A. Nellore2, R. Thompson2, J. Lan1, L. Allan1, P. A. Keown1

    1Vancouver General Hospital, Vancouver, BC, Canada, 2Biomedical Engineering, Oregon Health & Science University, Portland, OR, 3Gunther Analytics, Vancouver, BC, Canada

    *Purpose: The incidence, clearance and clinical expression of viremia post-Tx are heterogeneous, complicating prediction, prognosis and therapy. We postulated that variation viral presentation related to…
  • 2021 American Transplant Congress

    Investigating the HLA Alloimmune Background of the Histological Changes Suggestive of Antibody-mediated Injury in the Absence of Donor-specific Anti-HLA Antibodies

    A. Senev, M. Naesens

    Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium

    *Purpose: The histology of antibody-mediated rejection is observed frequently after kidney transplantation, but a significant percentage of the patients do not have detectable donor-specific HLA…
  • 2020 American Transplant Congress

    Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk

    W. S. Oetting1, G. Weihua1, C. R. Dorr1, R. B. Mannon2, A. J. Matas1, P. A. Jacobson1, A. K. Israni1

    1University of Minnesota, Minneapolis, MN, 2University of Alabama, Birmingham, AL

    *Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…
  • 2020 American Transplant Congress

    The Impact of HLA-DQ Molecular Mismatches on De Novo Occurrence of Donor-Specific Anti-HLA Antibodies after Kidney Transplantation: An Observational Cohort Study

    A. Senev1, M. Coemans1, V. Van Sandt2, E. Van Loon1, J. Callemeyn1, B. Sprangers1, D. Kuypers1, M. Emonds1, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2HILA, Red Cross-Flanders, Mechelen, Belgium

    *Purpose: Evaluating HLA molecular mismatches (MM) instead of antigen mismatches might be a better tool to assess donor-recipient HLA incompatibility and provide a better risk…
  • 2020 American Transplant Congress

    Low HLA Class I Epitope Mismatch Associated with Improved Pancreas Graft Survival in Simultaneous Pancreas-Kidney Transplantation

    J. M. Ladowski, M. Romine, D. Kloda, C. Young, J. Locke, V. Hauptfeld-Dolejsek, J. Houp

    University of Alabama-Birmingham, Birmingham, AL

    *Purpose: Antibody-mediated rejection remains the principal cause of allotransplant graft failure. Human leukocyte antigen (HLA) matching between donor and recipients significantly reduces the risk of…
  • 2020 American Transplant Congress

    Calculated Panel Reactive Antibody Values Increase for Kidney Transplant Candidates with HLA-DQA and HLA-DPB Unacceptable Antigens

    E. P. Kransdorf1, C. Murphey2, M. Maiers3, L. Gragert4

    1Cedars-Sinai Heart Institute, Beverly Hills, CA, 2Immunogenetics Lab, Southwest Immunodiagnostics, Inc., San Antonio, TX, 3Bioinformatics Research, Be The Match/National Marrow Donor Program, Minneapolis, MN, 4Department of Pathology, Tulane University School of Medicine, New Orleans, LA

    *Purpose: Calculated panel-reactive antibody (CPRA) is the official metric of sensitization used by the United Network for Organ Sharing (UNOS) for kidney allocation. CPRA includes…
  • 2020 American Transplant Congress

    HLA Diversity Affects Epitope Mismatch Cutoffs Utilized to Predict De Novo DSA Development and Graft Rejection in Renal Transplant Patients

    A. Ram1, S. Dhingra2, H. Quach1, P. T. Jindra1

    1Immune Evaluation Laboratory-Surgery, Baylor College of Medicine, Houston, TX, 2Pathology, Baylor College of Medicine, Houston, TX

    *Purpose: Recent studies have investigated epitope matching in order to determine its predictive power in determining renal transplant outcomes, both in terms of de novo…
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