ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histocompatibility"

  • 2022 American Transplant Congress

    A Novel Application of SRTR Data to Interrogate the Effects of HLA-DQ Mismatches in Kidney Transplantation

    D. Isaacson1, M. W. Gmeiner2, V. Kosmoliaptsis3, H. C. Copley3, J. D. Schold4, A. R. Tambur1

    1Northwestern University, Chicago, IL, 2London School of Economics, London, United Kingdom, 3Cambridge University, Cambridge, United Kingdom, 4Cleveland Clinic, Cleveland, OH

    *Purpose: Single-center studies demonstrate de-novo HLA-DQ donor-specific antibodies (DSA) are the most common and pathogenic DSA. However, HLA-DQ is not accounted for in many kidney…
  • 2022 American Transplant Congress

    Which is More Important for Predicting De Novo DSA Production, B Cell Epitope (EPLET) or T Cell Epitope (PIRCHE) Analysis ?

    T. Kobayashi1, T. Tomosugi2, S. Sakamoto2, S. Ashimine1, K. Iwasaki1, M. Niemann3, E. Spierings4, Y. Miwa1, M. Okumura1, K. Ishiyama1, A. Takeda2, N. Goto2, S. Narumi2, Y. Watarai2

    1Aichi Medical University School of Medicine, Nagakute, Japan, 2Nagoya Daini Red Cross Hospital, Nagoya, Japan, 3PIRCHE AG, Berlin, Germany, 4UMC Utrecht, Utrecht, Netherlands

    *Purpose: De novo donor-specific antibodies (dnDSA) can cause chronic ABMR, resulting in poor prognosis. Recently, mismatch at B cell epitope level, i.e. EPLET mismatch, has…
  • 2022 American Transplant Congress

    Long-Term Outcomes of Crossmatch Positive Simultaneous Liver Kidney Transplants in the United States

    S. Riad1, E. Aby1, S. Jackson2, P. Nguyen3, N. Lim1, J. Lake1

    1Medicine, University of Minnesota, Minneapolis, MN, 2Mhealth-Fairview, Minneapolis, MN, 3Surgery, University of Minnesota, Minneapolis, MN

    *Purpose: The long-term results of crossmatch positive (XM+) simultaneous liver-kidney (SLK) transplants are conflicting. We examined the association between crossmatch (XM) status and SLK outcomes…
  • 2022 American Transplant Congress

    Simultaneous Liver/ Kidney Transplant Reduces Both Donor Specific and Non-Donor Specific HLA Antibodies

    X. Zhang, S. Wisel, I. Kim, S. Jordan

    Cedars Sinai Medical Center, Los Angeles, CA

    *Purpose: Kidney allografts can be transplanted across strong donor specific antibody (DSA) barriers in simultaneous liver/kidney transplant (SLK) recipients. It is suggested that preformed DSAs…
  • 2022 American Transplant Congress

    Complete and High-Resolution HLA Typing Improves the Accuracy of Post-Transplant Assessment of De Novo Anti-Donor Immune-Mediated Events

    M. Meneghini1, A. Perona2, E. Crespo3, F. J. Bemelman4, P. M. Reinke5, O. Viklicky6, M. Giral7, O. Bestard1

    1Vall d'Hebron University Hospital, Barcelona, Spain, 2Universitat de Barcelona, Barcelona, Spain, 3Nephrology and Transplantation Laboratory, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, 4Amsterdam University Medical Centers, Amsterdam, Netherlands, 5Charité Universitätsmedizin, Berlin, Germany, 6Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, 7Nantes Université, Inserm, CHU Nantes, Nantes, France

    *Purpose: High-resolution (HR) HLA typing using NGS technology has shown to improve the accuracy of assessing donor-recipient compatibility and characterization of pre-transplant anti HLA antibodies…
  • 2022 American Transplant Congress

    High Resolution Typing Can Improve Accuracy and Sensitivity of the Virtual Crossmatch for Sensitized Patients – A Single Center’s Experience

    C. MarElia-Bennett1, V. Rohan2, K. Twombley3, O. Moussa1

    1Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 2Surgery, Medical University of South Carolina, Charleston, SC, 3Medical University of South Carolina, Charleston, SC

    *Purpose: The introduction of solid phase assays has significantly enhanced our ability to execute virtual crossmatches (VXMs). However, this method is not without its shortcomings.…
  • 2022 American Transplant Congress

    ABO Hemagglutination Titres Do Not Accurately Reflect ABO Antibody Levels

    A. Halpin1, T. Ellis2, J. Pearcey2, B. Motyka2, T. L. Lowary3, C. Cairo4, S. Maier2, L. J. West5

    1Pediatrics/Dept of Laboratory Medicine, University of Alberta/Alberta Precision Laboratories, Edmonton, AB, Canada, 2Pediatrics, University of Alberta, Edmonton, AB, Canada, 3Academia Sinica, Institute of Biological Chemistry, Taipei, Taiwan, 4Chemistry, University of Alberta, Edmonton, AB, Canada, 5Pediatrics, University of Alberta, Canadian Donation and Transplant Research Program, Edmonton, AB, Canada

    *Purpose: ABO antibody (ABO-Ab) quantification is essential for risk assessment for ABO-incompatible (ABOi) transplantation, but the hemagglutination assay (HA) for ABO-Ab titres is known to…
  • 2022 American Transplant Congress

    Beyond CPRA: Identifying Sensitized Kidney Candidates with Markedly Low Access to Transplant

    K. Bradbrook1, A. Maldonado2, K. Sjöholm2, C. Kjellman2, J. Lee3, D. Stewart1

    1UNOS, Richmond, VA, 2Hansa Biopharma AB, Lund, Sweden, 3Immucor, Norcross, GA

    *Purpose: The Kidney Allocation System (KAS) improved the rates of transplantation in highly sensitized (HS) patients. However, a subset of HS patients remain at a…
  • 2022 American Transplant Congress

    Production of Exosomal IL35 from Alloreactive Treg Cells: A Basis for Potent Immunotherapy and Tolerance in Human Kidney Transplantation

    W. J. Burlingham1, E. Jankowska-Gan2, J. Fechner1, C. Little1, S. Tripathi3, B. Schreiber3, A. Chandraker3, D. Foley4

    1Surgery-Transplant Division, University of Wisconsin, Madison, WI, 2Surgery-Transplant Division, University of Wisconsin-Madison, Madison, WI, 3Surgery-Transplant Division, Brigham & Women's Hospital, Boston, MA, 4University of Wisconsin, Madison, WI

    *Purpose: Treg cells make a variety of immunosuppressive products—cytokines such as IL10, TGFβ, and IL35, and enzymes such as the CD39/CD73 pair that convert extracellular…
  • 2022 American Transplant Congress

    HLA-Specific IgD/CD27 Double Negative B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Rejection in Kidney Transplant Recipients

    Z. Ilyas1, A. Akl2, D. Pinelli1, L. Gallon3, A. Tambur1, M. Ansari4

    1Northwestern University, Chicago, IL, 2Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia, 3Northwestern Univ NMFF, Chicago, IL, 4Medicine, Northwestern University, Chicago, IL

    *Purpose: Recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at higher immunologic…
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