Articles tagged "Heart/lung transplantation"

2018 American Transplant Congress
Influence of Dendritic Cell Subsets on Enhancing Oral Tolerance in Cardiac Transplantation Model
G. Gu, T. Lu, N. Xu, Q. Xia.
Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University Medical School, Shanghai, China.
Oral tolerance has been implicated in the protection of transplant rejection in the animal models. Antigen presenting cells (APCs) are responsible for sampling their environment…
2018 American Transplant Congress
IL-10 Requirement in In Vitro Expanded Breg-Mediated Allograft Tolerance is Tissue Specific
C. Dai, K. Lee, L. Kojima, K. Deng, S. Kimura, C. Rickert, H. Yeh, J. Markmann.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Introduction:Regulatory B cells (Bregs) have shown several multiple mechanisms of suppression, including Treg induction and IL-10 production. Consistent with work of other groups on Breg…
2018 American Transplant Congress
CD8-Expressing Transitional B Cells Dominate B Cell Reconstitution in Transplanted Monkeys Receiving Mixed Chimerism Conditioning
K. Pruner, J. Paster, S. Wiebke, O. Jane, H. Isabel, D. Abbas, B. Gilles, M. Joren.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
IntroductionTolerance of heart or lung allografts have been achieved for the first time in nonhuman primates (NHPs) using a mixed chimerism conditioning regimen. However, the…
2018 American Transplant Congress
Long Noncoding RNA NEAT1 Induces Tolerogenic Dendritic Cells in Heart Transplantation
J. Wu,^1,2 Y. Zheng,^1,2 S. Li,^1,2 M. Zhang,^1,2 H. Zhang,^1,2 X. Zheng,^1,2 Y. Sun,^1,2 B. Yu.^1,2
¹Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China; ²The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Purpose: Tolerogenic dendritic cells have been gaining interest as an efficient means of promoting antigen-specific tolerance in organ transplantation. Long noncoding RNA NEAT1 plays an…
2018 American Transplant Congress
Potential Impact of DCD Donor Recoveries on Heart Transplantation: Retrospective Analysis of a Limited UNOS Dataset
J. Lindower,² M. Farr,¹ S. Taylor,² U. Jorde,³ L. Chen,⁴ A. Gass,⁵ L. Truby,¹ S. Delair,² S. Pinney.⁶
¹New York Cardio-Thoracic Transplant Consortium, Troy, NY; ²Columbia/New York Presbyterian Hospital, New York; ³Montefiore Medical Center, Bronx, NY; ⁴Rochester University Medical Center, Rochester, NY; ⁵Westchester Medical Center, Valhalla, NY; ⁶Mount Sinai Medical Center, New York, NY.
Purpose: To review the volume and quality of potential DCD (Donation after Cardiac Death) Heart Transplant (HT) donors in the US, evaluate trends over time…
2017 American Transplant Congress
Simultaneous Heart and Kidney Transplant vs Heart Transplant: Single Center Review of Candidate Selection and List Management.
N. Fonseka,¹ H. Mangrolia,¹ S. Karhadkar,² S. Rao,² L. Punnoose.¹
¹Temple Heart and Vascular Institute, Lewis Katz School of Medicine at Temple University, Philadelphia, PA; ²Temple Kidney Transplant Program, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
Background: Increasing numbers of patients with advanced heart and kidney failure undergo simultaneous heart kidney transplant (SHK). Selection criteria in patients with non-dialysis dependent kidney…
2017 American Transplant Congress
Severe Tricuspid Regurgitation After Heart Transplantation: Does It Require Surgical Repair?
J. Patel, M. Kittleson, L. Czer, T. Aintablian, R. Sharoff, R. Levine, A. Velleca, D. Ramzy, F. Esmailian, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Background: Tricuspid regurgitation (TR) after heart transplantation is common. Causes for TR may be due to volume overload, flail tricuspid leaflet from endomyocardial biopsy, pulmonary…
2017 American Transplant Congress
Preventing Alloimmune Rejection in Heart Transplantation by Tolerogenic Dendritic Cells Induced by GDF15 Through Up-Regulation of IDO and Inhibition of the NFκB Signalling Pathway.
Y. Zhang,^1,3 G. Zhang,¹ L. Moszczynski,¹ D. Zhao,^1,3 P. Abulizi,¹ D. Quan,² T. Mele,² K. Liu,³ X. Zheng.^1,2
¹Pathology, University of Western Ontario, London, ON, Canada; ²Surgery, University of Western Ontario, London, ON, Canada; ³Cardiovascular Surgery, Jilin University, Cahngchun, China
Rationale: Growth differentiation factor 15 (GDF15) can inhibit DC maturation, yet whether it can generate tolerogenic dendritic cells (Tol-DCs) to induce immune tolerance in heart…
2017 American Transplant Congress
Ethylene Carbodiimide Fixed Donor Splenocytes Combined with α-1 Antitrypsin Induce Indefinite Donor Specific Protection to Mice Cardiac Allografts.
G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, J. Zhang, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Peritransplant infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) induces protection of islet and cardiac allografts. However, pro-inflammatory cytokine production during the peritransplantation period may negate…
2017 American Transplant Congress
Heat Shock Protein 90 Inhibitor, 17DMAG Suppresses Acute Allograft Rejection and Prolongs Allograft Survival in Solid Organ Transplantation.
T. Maehana, T. Tanaka, N. Masumori.
Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…