2022 American Transplant Congress
Cd47 Expression on Transplanted Human Neonatal Mesenchymal Stem Cells Inhibits Phagocytosis in Rat Myocardial Infarction Model
Lurie Childrens Hospital, Chicago, IL
*Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal mesenchymal stem cells…2021 American Transplant Congress
Adult Combined Liver-Heart Transplantation: The United States Experience
*Purpose: Combined heart-liver transplantation (CHLT) is now being practiced with increasing regularity and improved outcomes in the United States. We performed the most comprehensive review…2021 American Transplant Congress
Intensivist-Performed Transesophageal Echocardiography as a Screen for Organ Donation: A Four-Year, Single-Center Experience
*Purpose: Echocardiography is required for deceased heart donation, and transthoracic echocardiography is the traditional practice. At our institution, intensivists perform transesophageal echocardiography (TEE) and since…2021 American Transplant Congress
A Patient-Centered Perspective on Progress in Transplantation
*Purpose: This study aimed to provide a patient-centered perspective on change in transplantation outcomes through analysis of intent-to-treat survival, which accounted for donor shortages by…2021 American Transplant Congress
Ex Situ Heart Perfusion and Standard of Care Cold Storage Differentially Affect the Ischemic Secretome of Donor Hearts in Perfusates but Not the Reperfusion Response in Recipient Plasma
*Purpose: Various allograft preservation procedures influence the donor organ status that may be reflected by the cytokine/chemokine microenvironment in heart transplant (HTx) recipients. In addition,…2021 American Transplant Congress
Changes to Adult Heart Allocation Improve Candidate Stratification
*Purpose: Historically, heart allocation has been driven by waitlist (WL) mortality rather than post-transplant survival. On 10/18/2018 the Organ Procurement and Transplantation Network (OPTN) implemented…2021 American Transplant Congress
DSA is Associated with Molecular Changes in Many Hearts with Minor Abnormalities but Not Diagnosed as Antibody-Mediated Rejection
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada
*Purpose: We previously developed a microarray-based diagnostic system (MMDx) for heart transplant endomyocardial biopsies, measuring gene expression and interpreting antibody-mediated and T cell-mediated rejection (ABMR,…2021 American Transplant Congress
Cd4 T Cells Can Trigger Nk-dependent Chronic Rejection Independent of Antibodies
*Purpose: In transplantation, recipient CD4+ T cells have two potential means of MHC class II-restricted donor antigen detection: (1) the direct recognition of allogeneic MHC…2021 American Transplant Congress
Change in Deceased Donor Demographics with Drug Intoxication Deaths: 2010 – 2019
*Purpose: To understand the demographic change in deceased donor causes of death associated with drug intoxication, we explored trends over the 10-year period ending in…2021 American Transplant Congress
Pig Orthotopic Heart Transplantation (ohtx) in Baboons: Is an Acute Pulmonary Inflammatory Response the Key Problem?
*Purpose: To investigate the mechanism of early cardio-pulmonary dysfunction after genetically engineered pig OHTx in baboons.*Methods: OHTx from pigs expressing different genetic modifications, α‐galactosyltransferase knockout…
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