Articles tagged "Heart"

2020 American Transplant Congress
Impact of Infectious Disease Intervention on Vaccine Compliance in Pediatric Heart Transplant Patients
S. R. Lauhon¹, G. Stendahl², P. Simpson³, S. J. Kindel², A. R. Punnoose², A. R. Huppler²
¹Medical College of Wisconsin, Wauwatosa, WI, ²Department of Pediatrics, Medical College of Wisconsin, Wauwatosa, WI, ³Division of Quantitative Health Sciences, Medical College of Wisconsin, Wauwatosa, WI
*Purpose: This study assesses the impact of including an Infectious Disease (ID) component in the pre-transplant evaluation on patients’ compliance with the CDC recommended vaccination…
2020 American Transplant Congress
Effect of Intravenous Ferric Gluconate on Post Heart Transplant Outcomes in Patients Bridged with Left Ventricular Assist Devices
N. Krepostman, D. Kim, D. Masic, S. Kuhrau, J. Negrelli, M. Liebo, E. Raichlin, A. Heroux, H. Basha
Internal Medicine, Loyola University Medical Center, Maywood, IL
*Purpose: Our study examined the effect of intravenous (IV) ferric gluconate compared to oral iron repletion in reducing 30-day hospital readmissions and all-cause mortality in…
2020 American Transplant Congress
Multiplicity of Non-HLA Targets for Antibodies Developed in Association with Ventricular Assist Device Implantation
M. Askar, D. Bhakta, H. Zafar, A. Alam, L. Pittmon, S. Kang, L. Klingman, J. Felius, S. M. Joseph, D. Wencker, D. M. Meyer, S. A. Hall
Baylor University Medical Center and Baylor Scott & White Research Institute, Dallas, TX
*Purpose: Multiple non-HLA antibodies have been implicated in poor outcomes after heart transplantation. Development of HLA and Non-HLA antibodies have been reported in association with…
2020 American Transplant Congress
Expression of Multiple Human Complement Regulatory Proteins Results in Prolonged Heterotopic Xenoheart Survival in an NHP Model
K. Ahrens¹, J. M. O¹, W. Sommer², D. Becerra¹, P. M. Patel¹, A. Dehnadi¹, Y. Kan³, J. Layer³, J. Morrissette¹, T. Costa¹, I. M. Hanekamp¹, J. S. Allan⁴, M. Youd³, R. N. Pierson⁵, W. Qin³, L. Burdorf⁵, A. M. Azimzadeh¹, W. Westlin³, L. Yang³, J. C. Madsen⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³eGenesis Inc., Cambridge, MA, ⁴Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, ⁵Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Advances in genome engineering technology allow for multiplex genetic modifications in pigs designed to address immunologic and coagulation incompatibilities in order to facilitate xenotransplantation.…
2020 American Transplant Congress
Characterization of Donor/Recipient Citizenship Status in Adult Heart Transplantation: A UNOS Registry Analysis
K. Yang¹, D. Miklin¹, J. Pizula¹, P. Genyk¹, G. Liu², A. Lee¹, S. Nuno¹, S. Hashmi¹, J. Nattiv², A. Kiankhooy³, L. Grazette², M. Fong², J. Rahman², K. Pandya², D. Vucicevic⁴, J. Li¹, P. Kingsford¹, P. Banankhah², R. Chand⁵, A. Wolfson⁶, S. Shah¹, A. Salimbangon⁷, C. Lum⁸, E. C. Depasquale², A. S. Vaidya²
¹Keck Medicine of USC, Los Angeles, CA, ²Cardiology, Keck Medicine of USC, Los Angeles, CA, ³Cardiothoracic Surgery, Keck Medicine of USC, Los Angeles, CA, ⁴Newark Beth-Israel Medical Center, Newark, NJ, ⁵Harbor-UCLA Medical Center, Torrance, CA, ⁶University of Arizona Sarver Heart Center, Tucson, AZ, ⁷UCLA Medical Center, Los Angeles, CA, ⁸The Queen's Medical Center, Honolulu, HI
*Purpose: There is a paucity of data describing heart transplant donor and recipient status. We therefore sought to examine the medical and demographic characteristics, and…
2020 American Transplant Congress
Computer-Assisted Cardiac Histologic Evaluation (CACHE) for Grading Cardiac Allograft Rejection
E. Peyster¹, S. ArabYarmohommadi², A. Janowczyk², M. Sekulic³, C. Cassol⁴, M. Feldman¹, K. Margulies¹, A. Madabhushi²
¹University of Pennsylvania, Philadelphia, PA, ²Case Western Reserve University, Cleveland, OH, ³University Hospitals Cleveland Medical Center, Cleveland, OH, ⁴Ohio State University, Columbus, OH
*Purpose: Cardiac allograft rejection (CAR) is a serious concern in heart transplantation, occurring in 30-40% of patients during the first year. Endomyocardial biopsy (EMB) with…
2020 American Transplant Congress
Vesicle-Associated Tweak is Increased During Acute Cellular Rejection and Contributes to Endothelial Inflammation
O. Gidlof, J. Sadrian, M. Grossi, S. Alcevska, J. Lundgren, G. Rådegran, G. Smith
Cardiology, Lund University, Lund, Sweden
*Purpose: Extracellular vesicles (EVs) are released from immune cells upon activation and play direct roles in allograft tolerance and rejection, in part through delivery of…
2020 American Transplant Congress
Management and Outcomes of Heart Transplant Recipients with Pre-Transplant Left Ventricular Assist Device Infections
Z. Esquer Garrigos, P. Vijayvargiya, J. M. Stulak, S. A. Rizza, M. R. Sohail
Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN
*Purpose: Infection involving Left Ventricular Assist Device (LVAD) in patients who receive device therapy as a bridge to heart transplantation (HT) is a serious complication.…
2020 American Transplant Congress
The Liver Protects All? Donor Specific Antibody Formation in Heart-Liver Transplant Recipients
A. W. Rogers¹, T. N. Eagar², C. Pham¹, J. Krisl¹, B. J. Pierce¹, M. Moaddab¹, R. Ghobrial³, B. Trachtenberg⁴, A. Bhimaraj⁴, A. O. Gaber³
¹Department of Pharmacy, Houston Methodist Hospital, Houston, TX, ²Department of Pathology, Houston Methodist Hospital, Houston, TX, ³Department of Surgery, Houston Methodist Hospital, Houston, TX, ⁴Houston Methodist Hospital, Houston, TX
*Purpose: Donor specific antibodies (DSAs) are key in the development of antibody mediated rejection (AMR). Their role in decreased patient and graft survival has been…
2020 American Transplant Congress
Neonatal Tolerance Induction: Behaviours of Allogeneic Spleen and Bone Marrow Inocula in Neonatal Mice are Largely Determined by the Nature of Their CD8 T Cells
R. A. Bascom, K. Tao, L. J. West
University of Alberta, Edmonton, AB, Canada
*Purpose: Injected adult allo-spleen (SC) and bone marrow cells (BMC) traffic to secondary lymphoid organs, proliferate and spread throughout neonatal mice; allo-SC consistently cause acute…