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American Transplant Congress abstracts

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Articles tagged "Heart"

  • 2022 American Transplant Congress

    Ventricular Modeling Following Bariatric Surgery Decreases Need for Heart Transplantation

    R. Choudhury1, A. Rouhi2, G. Hoeltzel3, Y. Bababekov1, A. Suarez-Pierre4, A. Yule1, N. Vigneshwar4, N. Williams5, K. Dumon2, T. Nydam1

    1Transplantation Surgery, University of Colorado Hospital, Aurora, CO, 2General Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, 3General Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, 4Cardiothoracic Surgery, University of Colorado Hospital, Aurora, CO, 5General Surgery, Hospital of the University of Pennsylvania, Aurora, CO

    *Purpose: For obese patients with congestive heart failure (CHF), aggressive weight loss has been associated with ventricular remodeling. Many have suggested offering bariatric surgery for…
  • 2022 American Transplant Congress

    Successful Use of Anti-IL-6R Therapy to Achieve Cardiac Allograft Tolerance in Non-Human Primates

    C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, A. Dehnadi, T. Costa, M. Momodu, J. A. Morrissette, D. Muldoon, I. M. Hanekamp, J. S. Allan, G. Benichou, J. C. Madsen

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: In contrast to kidney allografts, attempts to achieve tolerance of isolated cardiac allografts in non-human primates (NHPs) using a mixed chimerism strategy have been…
  • 2022 American Transplant Congress

    Estimating the Effect of Increased Donor Heart Ischemic Time on Post-Transplant Survival Using Instrumental Variables

    G. Ran1, K. Lazenby1, N. Narang2, W. F. Parker3

    1Pritzker School of Medicine, University of Chicago, Chicago, IL, 2Department of Medicine, University of Illinois-Chicago, Chicago, IL, 3Department of Medicine, University of Chicago, Chicago, IL

    *Purpose: Isolate the impact of organ ischemic time on post-transplant survival using the recent change in heart allocation policy as a natural experiment.*Methods: We examined…
  • 2022 American Transplant Congress

    Outcome of Solid Organ Transplantation in Candidates with Intellectual Disability: A Systematic Review

    L. Orlandini

    Erasmus MC, Rotterdam, Netherlands

    *Purpose: The allocation of organs comes with an ethical discussion in patients with intellectual disability. Historically, intellectual disability was considered a relative contra-indication for organ…
  • 2022 American Transplant Congress

    The Role of Geography in Adult Heart Allocation Over the Last 5 Years

    K. Bradbrook1, R. Goff1, R. Daly2, S. Hall3

    1Research, United Network for Organ Sharing, Richmond, VA, 2Mayo Clinic, Rochester, MN, 3Baylor University Medical Center, Dallas, TX

    *Purpose: In the last 5 years two policies have impacted the role of geography in adult heart allocation including the 2018 adult heart policy which…
  • 2022 American Transplant Congress

    Cd47 Expression on Transplanted Human Neonatal Mesenchymal Stem Cells Inhibits Phagocytosis in Rat Myocardial Infarction Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal

    Lurie Childrens Hospital, Chicago, IL

    *Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal mesenchymal stem cells…
  • 2022 American Transplant Congress

    Correlating Histology, Immunohistochemical, & Serologic Data in Heart Transplant Recipients: Implications for Molecular Diagnostic Assays

    P. Randhawa, Y. Huang

    University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: The ISHLT classification of rejection in heart allograft biopsies is independent of DSA status. There is only limited data on the prevalence of DSA…
  • 2022 American Transplant Congress

    Significant Reduction of Troponin I Elaboration After Ischemia Minimization in the First Hour of Ex Vivo Xeno Heart Perfusion

    F. Pollok1, M. R. Connolly1, A. Calhoun1, Z. Habibabady1, S. Miura1, M. Ma1, S. Pratts1, L. Burdorf1, Y. Kan2, J. V. Layer2, J. V. Layer2, E. Tan2, R. Anand2, M. Li2, K. C. Hall2, M. E. Youd2, K. Stiede2, W. Qin2, M. Curtis2, A. Azimzadeh1, R. N. Pierson1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Cambridge, MA, 2eGenesis Inc., Cambridge, MA

    *Purpose: Previous studies showed that ischemia minimization (IM), accomplished by perfusing the heart xenograft during storage, prevents ‘initial cardiac xenograft dysfunction’ (ICXD) and enables prolonged…
  • 2022 American Transplant Congress

    Equity in Access to Deceased Donor Transplant for Candidates on the Heart Waitlist

    K. Bradbrook1, A. Robinson1, R. Goff1, D. Stewart2

    1Research, United Network for Organ Sharing, Richmond, VA, 2United Network for Organ Sharing, Richmond, VA

    *Purpose: Transplantation is often the gold standard therapy for those with organ failure, but limited supply prevents all patients from accessing this treatment. The Organ…
  • 2022 American Transplant Congress

    Association Between Allograft Gene Expression and Acute Cellular Rejection Grade in Heart Transplant Recipients

    A. Kao1, K. Haffey2, K. T. Gondi3, J. Linard2, C. Knutson2, K. Morgan2, L. Teterina2, S. Williams2, K. Oreschak4, H. Zhang4

    1St. Luke's Health System Kansas City Mid America Heart Institute, Kansas City, MO, 2St. Luke's, Kansas City, MO, 3University of Michigan, Ann Arbor, MI, 4CareDx, South San Francisco, CA

    *Purpose: Endomyocardial biopsy (EMB) remains the gold standard in acute rejection (AR) surveillance in heart transplantation (HT) despite interpretation subjectivity and low concordance rates between…
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