2022 American Transplant Congress
Derivation of a Cardiac Risk Index for Use in Liver Transplantation for Non-Alcoholic Steatohepatitis
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Cardiovascular events (CVEs) are the most common cause of early mortality after liver transplant (LT), and LT candidates with non-alcoholic steatohepatitis (NASH) are at…2022 American Transplant Congress
Recipient’s Age Does Not Impact Survival After Simultaneous Heart and Kidney Transplant
*Purpose: Simultaneous heart and kidney transplantation (SHKT) is the treatment of choice for patients who suffer both from end-stage heart and kidney disease. However, the…2022 American Transplant Congress
Donor-Derived Cell-Free DNA Across the Spectrum of Solid Organ Transplantation
1Baylor Scott & White Health, Temple, TX, 2CareDx, Inc, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a robust and clinically useful analyte initially validated for kidney allograft surveillance. Emerging data support the utility of dd-cfDNA…2022 American Transplant Congress
An Updated Estimate of Post-Transplant Survival After Implementation of the New Donor Heart Allocation Policy
*Purpose: Published estimates showing lower post-transplant survival after implementation of the new heart allocation policy may be biased downward due to incomplete follow-up on surviving…2022 American Transplant Congress
TNX-1500, an Fc-Modified Anti-cd154 Antibody, Prolongs Nonhuman Primate Cardiac Allograft Survival
*Purpose: Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to replace current clinical immunosuppression. TNX-1500 (TNX) is a novel humanized anti-CD154…2022 American Transplant Congress
Ventricular Modeling Following Bariatric Surgery Decreases Need for Heart Transplantation
*Purpose: For obese patients with congestive heart failure (CHF), aggressive weight loss has been associated with ventricular remodeling. Many have suggested offering bariatric surgery for…2022 American Transplant Congress
Successful Use of Anti-IL-6R Therapy to Achieve Cardiac Allograft Tolerance in Non-Human Primates
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: In contrast to kidney allografts, attempts to achieve tolerance of isolated cardiac allografts in non-human primates (NHPs) using a mixed chimerism strategy have been…2022 American Transplant Congress
Estimating the Effect of Increased Donor Heart Ischemic Time on Post-Transplant Survival Using Instrumental Variables
*Purpose: Isolate the impact of organ ischemic time on post-transplant survival using the recent change in heart allocation policy as a natural experiment.*Methods: We examined…2022 American Transplant Congress
Outcome of Solid Organ Transplantation in Candidates with Intellectual Disability: A Systematic Review
Erasmus MC, Rotterdam, Netherlands
*Purpose: The allocation of organs comes with an ethical discussion in patients with intellectual disability. Historically, intellectual disability was considered a relative contra-indication for organ…2022 American Transplant Congress
The Role of Geography in Adult Heart Allocation Over the Last 5 Years
*Purpose: In the last 5 years two policies have impacted the role of geography in adult heart allocation including the 2018 adult heart policy which…
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