ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Heart"

  • 2018 American Transplant Congress

    Geographic Variation in the Survival Benefit of Heart Transplantation

    W. Parker,1 R. Gibbons,1 M. Churpek,1 A. Anderson.2

    1University of Chicago, Chicago, IL; 2Northwestern University, Chicago, IL.

    Purpose: Heart transplant candidate selection and treatment practices vary substantially across the US. We aimed to determine if transplant center practices modify the survival benefit…
  • 2018 American Transplant Congress

    Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant

    A. Cherry,1 K. Porter,1 H. Suliman,1 J. Wang,2 M. Mulvihill,2 A. Kirk.2

    1Anesthesiology, Duke University, Durham, NC; 2Surgery, Duke University, Durham, NC.

    Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…
  • 2018 American Transplant Congress

    Increasing Use of Exceptions after Changes to Pediatric Heart Allocation

    A. Robinson,1 W. Mahle,2 R. Davies.3

    1United Network for Organ Sharing, Richmond, VA; 2Children's Healthcare of Atlanta, Atlanta, GA; 3Children's Medical Center of Dallas, Dallas, TX.

    Purpose: Pediatric heart allocation in the United States was changed in 2016. The primary goal was to better align candidate status with waitlist mortality. Whether…
  • 2018 American Transplant Congress

    T-Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell Generation and Regulatory-T-Cell-Dependent Cardiac Allograft Survival

    N. Chun,1 D. Verghese,1 M. Demir,1 M. Fribourg,3 I. Llaudo,1 E. Medof,4 P. Heeger.1

    1Div of Nephrology, Dept of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, NY, NY; 2Dept of Neurology, Icahn School of Medicine at Mount Sinai, NY, NY; 3Dept of Pathology, Case Western Reserve Univ, Cleveland, OH.

    C5aR2 (C5L2/gp77) is a transmembrane receptor that binds C5a but lacks motifs needed to induce G-protein coupled signal transduction. C5aR2 modulates various inflammatory diseases in…
  • 2018 American Transplant Congress

    Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft Rejection

    Z. Zhang,1 Q. Liu,1 G. Hussey,2 J. Dziki,2 L. Mathews,1 H. Dai,1 G. Dwyer,1,3 A. Lucas,1 M. Oberbarnscheidt,1 S. Badylak,2 H. Turnquist.1,3

    1University of Pittsburgh, Starzl Transplant Institute, Pittsburgh, PA; 2University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, PA; 3Immunology, University of Pittsburgh, Pittsburgh, PA.

    Purpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…
  • 2018 American Transplant Congress

    IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection

    J. Breidenbach, C. Baum, P. Schroder, S. Stepkowski.

    Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Science, Toledo, OH.

    Background: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system, making it an attractive target for reducing chronic allograft rejection…
  • 2018 American Transplant Congress

    Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection

    J. Nie,1 B. Ramaswami,2 X. Guo,3 R. Hoffman,2 G. Chalasani.3

    1Thoracic Surgery, Huazhong University of Science and Technology, Wuhan, Hubei, China; 2Surgery, Starzl Transplantation Institute, Pittsburgh, PA; 3Medicine, University of Pittsburgh, Pittsburgh, PA.

    Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…
  • 2018 American Transplant Congress

    Functional Assessment of Kidney Transplant Candidates with the 6 Minute Walk Test and Hand Grip Strength

    S. Anand,1 S. Gilligan,2 D. Morris,1 T. Srinivas.

    1Transplant Nephrology, Intermountain Healthcare, Murray; 2University of Utah, Murray, UT.

    Background: The 6 minute walk test distance (6MWT) and Isometric hand grand grip strength (HGS) have been studied in various settings as objective measures of…
  • 2017 American Transplant Congress

    Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection.

    A. Loupy,1 J. Duong Van-Huyen,1 L. Hidalgo,2 J. Reeve,2 M. Racapé,1 O. Aubert,1 J. Venner,2 D. Viglietti,1 P. Bruneval,1 C. Lefaucheur,1 P. Halloran.2

    1Paris Translational Research Center for Organ Transplantation, Paris, France; 2University of Alberta, Edmonton, Canada

    Antibody-mediated rejection (AMR) is a major determinant of heart allograft loss. However, the specific effects of anti-HLA antibodies on heart allograft injury have not been…
  • 2017 American Transplant Congress

    A-Antigen (Ag)-Specific Tolerance Following A-Ag Administration to Infant Mice.

    B. Motyka,1 Y. Wang,1 B. Lamarche,1 I. Adam,1 J. Pearcey,1 K. Tao,1 C. Cairo,2 P. Cowan,3 L. West.1

    1Dept Pediatrics, Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada; 2Dept Chemistry, Alberta Glycomics Centre, University of Alberta, Edmonton, Canada; 3Immunology Research Centre, St Vincent's Hospital, University of Melbourne, Melbourne, Australia

    Purpose: In contrast to adults, ABO-incompatible heart transplantation (ABOi HTx) can safely be performed in infants due to absent/low levels of anti-A/B antibodies (Ab). Tolerance…
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