2018 American Transplant Congress
Screening of RhoA/ROCK Inhibitors for the Ability to Prevent Chronic Rejection of Mouse Cardiac Allografts
Objectives. Chronic rejection of transplanted organs is a major obstacle in human organ transplantation. Although the mechanisms of chronic rejection are poorly understood it is…2018 American Transplant Congress
Heart and Lung Offer Acceptance Practices Are Associated with Organ Yield and Local Placement
Below average offer acceptance practices could delay placement of donor hearts and lungs and may ultimately lead to organ discard. Recovered thoracic organs are rarely…2018 American Transplant Congress
T Cell-Mediated Rejection Poses Greater Risk to Graft Survival Than Antibody-Mediated Rejection in Heart Transplants
University of Alberta, Edmonton, Canada.
Purpose: In kidney transplants, failure post-biopsy is associated with acute injury transcript expression reflecting the histologically silent tissue response-to-wounding (JCI 120:1862) and antibody-mediated rejection (ABMR),…2018 American Transplant Congress
Experience in the Development of a Life-Supporting Large Animal Orthotopic Cardiac Xenotransplant Model
Advances in clinical immunosuppression and characterization of optimal donor genetics continue to move the field of xenotransplantation toward a clinical reality with extremely long-term survival…2018 American Transplant Congress
Geographic Variation in the Survival Benefit of Heart Transplantation
1University of Chicago, Chicago, IL; 2Northwestern University, Chicago, IL.
Purpose: Heart transplant candidate selection and treatment practices vary substantially across the US. We aimed to determine if transplant center practices modify the survival benefit…2018 American Transplant Congress
Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant
1Anesthesiology, Duke University, Durham, NC; 2Surgery, Duke University, Durham, NC.
Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…2018 American Transplant Congress
Increasing Use of Exceptions after Changes to Pediatric Heart Allocation
Purpose: Pediatric heart allocation in the United States was changed in 2016. The primary goal was to better align candidate status with waitlist mortality. Whether…2018 American Transplant Congress
T-Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell Generation and Regulatory-T-Cell-Dependent Cardiac Allograft Survival
C5aR2 (C5L2/gp77) is a transmembrane receptor that binds C5a but lacks motifs needed to induce G-protein coupled signal transduction. C5aR2 modulates various inflammatory diseases in…2017 American Transplant Congress
Trends in the Number and Medical Urgency of Adult Heart Transplant Candidates Listed as Status 1A from 2006-2015.
The wider geographic sharing of hearts in 2006 may have had unintended consequences for transplant center listing behavior. This project examines trends in the number…2017 American Transplant Congress
Implementing a Successful DCD Heart Programme to the United Kingdom.
Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, United Kingdom
The UK has the most successful DCD heart programme in the world which has primarily been developed in one region in England. Due to a…
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