ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Heart"

  • 2018 American Transplant Congress

    ABO Tolerance after Treatment of Infant or Adult Mice with MHC-Matched A-Expressing Blood Cells

    B. Motyka,1 J. Fersovich,1 B. Lamarche,1 M. Sosniuk,1 I. Adam,1 J. Pearcey,1 K. Tao,1 C. Cairo,2 P. Cowan,3 L. West.1

    1Dept Pediatrics, Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada; 2Dept Chemistry, University of Alberta, Edmonton, Canada; 3St Vincent's Hospital, Melbourne, Australia.

    Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. Post-ABOi HTx B cell tolerance develops to donor blood group…
  • 2018 American Transplant Congress

    Geographic Variation in the Treatment of Adult Heart Transplant Candidates in the US

    W. Parker,1 M. Churperk,1 D. Hedeker,1 E. Huang,1 E. Garrity,1 M. Siegler,1 A. Anderson.2

    1University of Chicago, Chicago, IL; 2Northwestern University, Chicago, IL.

    The current priority ranking system for US heart transplant candidates is based on treatment intensity which may encourage the overtreatment of relatively stable candidates. We…
  • 2018 American Transplant Congress

    Myeloid-Derived Suppressor Cells Suppress with Enhanced Donor Specificity in Donor ECDI-SP Treated Recipients

    L. Zhang, J. Wang, Z. Zhang, X. Luo.

    Northwestern University Feinberg School of Medicine, Chicago.

    Introduction: Published data in cancer models have shown that myeloid-derived suppressor cells (MDSCs) can induce antigen-specific CD8 T cell tolerance and promote tumor escape (Nagaraj…
  • 2018 American Transplant Congress

    Heart Transplantation in Patients with Complex Congenital Heart Disease

    M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa, R. Garg, E. Zahn.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: As medical and surgical management of complex congenital heart disease (CCHD) improves, patients may survive into adulthood to suffer from end-stage heart failure and…
  • 2018 American Transplant Congress

    Human Thrombomodulin Expression on Genetically Modified Donor Pigs is Required to Maintain the Anti-Coagulation Profile

    A. Singh, L. DiChiacchio, J. Chan, P. Corcoran, B. Lewis, M. Thomas, D. Ayares, K. Horvath, M. Mohiuddin.

    CSRP/NHLBI and DVR/ORS, NIH, Bethesda, MD; Revivicor Inc., Blacksburg, VA; Dept of Surgery, University of Maryland, Baltimore, MD.

    Introduction: Coagulation dysregulation is major limitation for xenotransplantation but it is resolved to some extent by making genetically engineered (GE) pigs, which express complement inhibitors…
  • 2018 American Transplant Congress

    Differences in Pediatric and Adult Lost to Follow-Up Events for Heart, Kidney, and Liver Recipients

    A. Robinson,1 G. Mazariegos,2 S. Bartosh,3 W. Mahle.4

    1United Network for Organ Sharing, Richmond, VA; 2Children's Hospital of Pittsburgh, Pittsburgh, PA; 3University of Wisconsin Hospital and Clinics, Madison, WI; 4Children's Healthcare of Atlanta, Atlanta, GA.

    Background: Long-term follow-up data are necessary for accurate survival estimation. While the majority of heart (HR), kidney (KI), and liver (LI) transplant recipients (TxR) are…
  • 2018 American Transplant Congress

    Screening of RhoA/ROCK Inhibitors for the Ability to Prevent Chronic Rejection of Mouse Cardiac Allografts

    W. Chen, W. Chen, X. Li, R. Ghobrial, M. Kloc.

    THMRI, Houston, TX.

    Objectives. Chronic rejection of transplanted organs is a major obstacle in human organ transplantation. Although the mechanisms of chronic rejection are poorly understood it is…
  • 2018 American Transplant Congress

    Heart and Lung Offer Acceptance Practices Are Associated with Organ Yield and Local Placement

    A. Wey, M. Skeans, N. Salkowski, B. Kasiske, A. Israni, J. Snyder.

    SRTR, Minneapolis.

    Below average offer acceptance practices could delay placement of donor hearts and lungs and may ultimately lead to organ discard. Recovered thoracic organs are rarely…
  • 2017 American Transplant Congress

    IL-3 Contributes to Development of Basophil-Triggered Cardiac Allograft Fibrosis Development.

    G. Schiechl-Brachner,1 M. Rodriguez Gomez,1 K. Renner,1 S. Buchtler,1 K. Schmidbauer,1 D. Halbritter,1 S. Neumayer,1 Y. Talke,1 H. Bruehl,2 M. Mack.1

    1Department of Internal Medicine II, University Hospital / Medical Center, Regensburg, Germany; 2Department of Internal Medicine I, University Hospital / Medical Center, Regensburg, Germany

    Introduction: Organ fibrosis and vasculopathy are major causes of chronic cardiac allograft failure. Resident (donor-derived) fibroblasts are thought to be mainly responsible for excessive production…
  • 2017 American Transplant Congress

    Donor Macrophage Depletion from CMV-Latently Infected Hearts Abrogates CMV-Accelerated Chronic Rejection.

    J. Burg,1 T. Andoh,2 N. Haese,2 I. Jones,2 S. Orloff,1 D. Streblow.2

    1Department of Surgery, OHSU, Portland, OR; 2VGTI, OHSU, Hillsboro, OR

    Purpose: Latent donor CMV infection has been shown to accelerate chronic rejection (CR) in a heterotopic rat heart transplant model. CMV latency is associated with…
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