2018 American Transplant Congress
Geographic Variation in the Survival Benefit of Heart Transplantation
1University of Chicago, Chicago, IL; 2Northwestern University, Chicago, IL.
Purpose: Heart transplant candidate selection and treatment practices vary substantially across the US. We aimed to determine if transplant center practices modify the survival benefit…2018 American Transplant Congress
Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant
1Anesthesiology, Duke University, Durham, NC; 2Surgery, Duke University, Durham, NC.
Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…2018 American Transplant Congress
Increasing Use of Exceptions after Changes to Pediatric Heart Allocation
Purpose: Pediatric heart allocation in the United States was changed in 2016. The primary goal was to better align candidate status with waitlist mortality. Whether…2018 American Transplant Congress
T-Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell Generation and Regulatory-T-Cell-Dependent Cardiac Allograft Survival
C5aR2 (C5L2/gp77) is a transmembrane receptor that binds C5a but lacks motifs needed to induce G-protein coupled signal transduction. C5aR2 modulates various inflammatory diseases in…2018 American Transplant Congress
Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft Rejection
Purpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…2018 American Transplant Congress
IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection
Background: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system, making it an attractive target for reducing chronic allograft rejection…2018 American Transplant Congress
Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection
Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…2018 American Transplant Congress
Functional Assessment of Kidney Transplant Candidates with the 6 Minute Walk Test and Hand Grip Strength
1Transplant Nephrology, Intermountain Healthcare, Murray; 2University of Utah, Murray, UT.
Background: The 6 minute walk test distance (6MWT) and Isometric hand grand grip strength (HGS) have been studied in various settings as objective measures of…2017 American Transplant Congress
Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection.
Antibody-mediated rejection (AMR) is a major determinant of heart allograft loss. However, the specific effects of anti-HLA antibodies on heart allograft injury have not been…2017 American Transplant Congress
A-Antigen (Ag)-Specific Tolerance Following A-Ag Administration to Infant Mice.
Purpose: In contrast to adults, ABO-incompatible heart transplantation (ABOi HTx) can safely be performed in infants due to absent/low levels of anti-A/B antibodies (Ab). Tolerance…
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