- 2018 American Transplant Congress - Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft RejectionPurpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…
- 2018 American Transplant Congress - IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft RejectionBackground: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system, making it an attractive target for reducing chronic allograft rejection…
- 2018 American Transplant Congress - Role of B Cell Intrinsic NLRP3 in the Development of Chronic RejectionEndogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…
- 2018 American Transplant Congress - Functional Assessment of Kidney Transplant Candidates with the 6 Minute Walk Test and Hand Grip Strength- 1Transplant Nephrology, Intermountain Healthcare, Murray; 2University of Utah, Murray, UT. Background: The 6 minute walk test distance (6MWT) and Isometric hand grand grip strength (HGS) have been studied in various settings as objective measures of…
- 2018 American Transplant Congress - Measures of Physical Frailty, Cardiac Function and Cardiac Biomarkers among Kidney Transplant Candidates- 1Intermountain Medical Center, Murray, UT; 2University of Utah, Salt Lake City, UT. Background: Elevated troponin T at transplant evaluation has been reported to confer risk of cardiovascular mortality among renal transplants. We use troponin T along with…
- 2018 American Transplant Congress - A Single Center Transition of Care Model from Pediatric Heart Recipients to Adult Services Ongoing Study Model- Heart Transplant, Vanderbilt Medical Center, Nashville, TN. This is an ongoing look at designing a pediatric to adult transition model and lessons learned over time. It has been shown that the first…
- 2018 American Transplant Congress - Mitochondrial Membrane Permeability Plays a Critical Role for Endothelial Cell Necroptosis and Cardiac Allograft RejectionBackground: Transplant injury is invariably associated with programmed cell death resulting in delayed graft function and organ rejection. We were the first to describe receptor-interacting…
- 2018 American Transplant Congress - ABO Tolerance after Treatment of Infant or Adult Mice with MHC-Matched A-Expressing Blood CellsPurpose: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. Post-ABOi HTx B cell tolerance develops to donor blood group…
- 2017 American Transplant Congress - HCC and Cardiac Cirrhosis After the Fontan Procedure in a Patient with Congenital Heart Disease and Situs Inversus.- Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX Introduction. Hypoplastic left heart syndrome (HLHS) is a fatal congenital cardiac anomaly for which surgical palliation is needed, the Fontan procedure. HLHS accounts for <5%…
- 2017 American Transplant Congress - Carotid Intima-Media Thickness and Myocardial Strain in Pediatric Kidney Transplant Recipients.- Children's National, Washington DC A prospective controlled longitudinal study was conducted to investigate determinants of carotid intima-media thickness (CIMT) and myocardial strain in children after kidney transplant (Tx).Methods: 42…
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