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Articles tagged "Heart"

  • 2022 American Transplant Congress

    Correlating Histology, Immunohistochemical, & Serologic Data in Heart Transplant Recipients: Implications for Molecular Diagnostic Assays

    P. Randhawa, Y. Huang

    University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: The ISHLT classification of rejection in heart allograft biopsies is independent of DSA status. There is only limited data on the prevalence of DSA…
  • 2022 American Transplant Congress

    Significant Reduction of Troponin I Elaboration After Ischemia Minimization in the First Hour of Ex Vivo Xeno Heart Perfusion

    F. Pollok1, M. R. Connolly1, A. Calhoun1, Z. Habibabady1, S. Miura1, M. Ma1, S. Pratts1, L. Burdorf1, Y. Kan2, J. V. Layer2, J. V. Layer2, E. Tan2, R. Anand2, M. Li2, K. C. Hall2, M. E. Youd2, K. Stiede2, W. Qin2, M. Curtis2, A. Azimzadeh1, R. N. Pierson1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Cambridge, MA, 2eGenesis Inc., Cambridge, MA

    *Purpose: Previous studies showed that ischemia minimization (IM), accomplished by perfusing the heart xenograft during storage, prevents ‘initial cardiac xenograft dysfunction’ (ICXD) and enables prolonged…
  • 2022 American Transplant Congress

    Equity in Access to Deceased Donor Transplant for Candidates on the Heart Waitlist

    K. Bradbrook1, A. Robinson1, R. Goff1, D. Stewart2

    1Research, United Network for Organ Sharing, Richmond, VA, 2United Network for Organ Sharing, Richmond, VA

    *Purpose: Transplantation is often the gold standard therapy for those with organ failure, but limited supply prevents all patients from accessing this treatment. The Organ…
  • 2022 American Transplant Congress

    Association Between Allograft Gene Expression and Acute Cellular Rejection Grade in Heart Transplant Recipients

    A. Kao1, K. Haffey2, K. T. Gondi3, J. Linard2, C. Knutson2, K. Morgan2, L. Teterina2, S. Williams2, K. Oreschak4, H. Zhang4

    1St. Luke's Health System Kansas City Mid America Heart Institute, Kansas City, MO, 2St. Luke's, Kansas City, MO, 3University of Michigan, Ann Arbor, MI, 4CareDx, South San Francisco, CA

    *Purpose: Endomyocardial biopsy (EMB) remains the gold standard in acute rejection (AR) surveillance in heart transplantation (HT) despite interpretation subjectivity and low concordance rates between…
  • 2022 American Transplant Congress

    The Use of Donor-Derived Cell-Free DNA in Female and Male Heart Transplant Recipients: A Sex-Specific Analysis of the Surveillance Heartcare Outcomes Registry

    E. M. DeFilippis1, Y. Fu2, R. Burke2, M. Deng3, M. Kamath4, L. Lourenco Jenkins2, A. R. Vest5

    1Columbia University Irving Medical Center, New York, NY, 2CareDx, Brisbane, CA, 3David Geffen School of Medicine at UCLA, Los Angeles, CA, 4Ronald Reagan UCLA Medical Center, Los Angeles, CA, 5Tufts Medical Center, Boston, MA

    *Purpose: To investigate sex-specific donor-derived cell-free DNA AlloSure (AS) levels during allograft quiescence and rejection after heart transplantation.*Methods: Sex-stratified data were obtained from the Surveillance…
  • 2022 American Transplant Congress

    Impaired Left Ventricular Global Longitudinal Strain: Clinical Presentation and Outcomes in Liver Transplantation Recipients without Arrhythmia or Structural Heart Disease

    M. B. Hammami, J. Grossman, P. Xue, H. Allaham, K. Eagan, S. Gottlieb, C. Hong, L. Wang, C. Bhati, D. Maluf, K. Shetty, N. Urrunaga

    University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Assess the prevalence and characteristics of patients without arrhythmia or structural heart disease (SHD) but with impaired pre-transplant left ventricular global longitudinal strain (GLS)…
  • 2022 American Transplant Congress

    De Novo Donor-Specific Antibody Development in Heart Transplant Recipients Following COVID-19 Vaccination

    M. Cheng1, O. Behbahani-Nejad1, D. Gupta2

    1Internal Medicine, Emory University School of Medicine, Atlanta, GA, 2Internal Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA

    *Purpose: To determine the incidence of de novo donor-specific antibodies (DSAs) in recipients of orthotopic heart transplants (OHT) who received an mRNA vaccine against SARS-CoV-2.*Methods:…
  • 2022 American Transplant Congress

    Left Ventricular Diastolic Dysfunction: Prevalence and Relation to Outcomes in Liver Transplantation Recipients

    M. B. Hammami1, H. Allaham2, J. Grossman2, P. Xue2, K. Eagan2, S. Gottlieb2, C. Hong2, L. Wang2, C. Bhati2, D. Maluf2, K. Shetty2, N. Urrunaga2

    1University of Maryland, Baltimore, MD, 2University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Assess the prevalence and characteristics of patients with pre-transplant left ventricular diastolic dysfunction (LVDD) and its potential impact on post-transplant morbidity and mortality.*Methods: Retrospective…
  • 2022 American Transplant Congress

    The Prevalence and Morbidity Associated with BK Virus in Heart Transplant Recipients

    A. Nguyen1, Z. Li2, N. F. Rasheed2, J. Cruz2, M. Fei3, G. Kim1, S. Pinney1, N. Uriel4

    1University of Chicago Medicine, Chicago, IL, 2University of Chicago, Chicago, IL, 3CareDx, Brisbane, CA, 4New York Presbyterian, Columbia University Irving Medical Center, New York, NY

    *Purpose: BK polyomavirus (BKV) is a quiescent polyomavirus that is present in approximately 80% of the population and can reactivate in immunocompromised patients and impair…
  • 2022 American Transplant Congress

    Pericardial Effusion: A Potential Late Complication of COVID-19 Infection

    O. Sogbein, A. Rizvi, M. Mujtaba, S. Hussain

    Internal Medicine, Division of Nephrology, University of Texas Medical Branch, Galveston, TX

    *Purpose: COVID-19 infection involves entry of SARS-CoV-2 virus into cells via interaction between its spike protein and angiotensin converting enzyme resulting in an NF-κβ mediated…
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