2022 American Transplant Congress
Changes in Diastolic Function and Cardiac Geometry After Pediatric Kidney Transplant: A Longitudinal Study
*Purpose: Kidney transplant recipients are at increased risk for cardiovascular disease but systolic function is often preserved and may not reveal cardiac dysfunction until it…2022 American Transplant Congress
Marginal Zone B Cells Support T Cell Reconstitution Following ATG Lymphoablation in Heart Allograft Recipients.
Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Lymphoablation with anti-thymocyte globulin (ATG) is a common therapy in solid organ transplantation. However homeostatic proliferation of pre-existing memory T cells undermines the graft-prolonging…2022 American Transplant Congress
The Gut Microbiome in the Critical Care Setting Post-Heart Transplantation
*Purpose: Given its potential impact on immune activation and systemic inflammation, we aim to investigate gut microbiome compositions and metabolites during critical illness in the…2022 American Transplant Congress
Resource Expenditure in the Evaluation of Older Donors for Heart Transplant: An Impediment to Donor Pool Expansion?
*Purpose: Using older donors for heart transplant (HT) could alleviate donor scarcity but the resource implications of this strategy - and whether evaluation of older…2022 American Transplant Congress
cDC1-Mediated Prolongation of Cardiac Allograft Survival and Alloantigen Induced Transcriptional Programming
Pathology, Northwestern Feinberg School of Medicine, Chicago, IL
*Purpose: Heart transplantation is currently the only treatment for advanced stage heart failure. While patient survival after transplantation has improved acutely, the same cannot be…2022 American Transplant Congress
Derivation of a Cardiac Risk Index for Use in Liver Transplantation for Non-Alcoholic Steatohepatitis
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Cardiovascular events (CVEs) are the most common cause of early mortality after liver transplant (LT), and LT candidates with non-alcoholic steatohepatitis (NASH) are at…2022 American Transplant Congress
Recipient’s Age Does Not Impact Survival After Simultaneous Heart and Kidney Transplant
*Purpose: Simultaneous heart and kidney transplantation (SHKT) is the treatment of choice for patients who suffer both from end-stage heart and kidney disease. However, the…2022 American Transplant Congress
Donor-Derived Cell-Free DNA Across the Spectrum of Solid Organ Transplantation
1Baylor Scott & White Health, Temple, TX, 2CareDx, Inc, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a robust and clinically useful analyte initially validated for kidney allograft surveillance. Emerging data support the utility of dd-cfDNA…2022 American Transplant Congress
An Updated Estimate of Post-Transplant Survival After Implementation of the New Donor Heart Allocation Policy
*Purpose: Published estimates showing lower post-transplant survival after implementation of the new heart allocation policy may be biased downward due to incomplete follow-up on surviving…2022 American Transplant Congress
TNX-1500, an Fc-Modified Anti-cd154 Antibody, Prolongs Nonhuman Primate Cardiac Allograft Survival
*Purpose: Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to replace current clinical immunosuppression. TNX-1500 (TNX) is a novel humanized anti-CD154…
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