2022 American Transplant Congress
An Updated Estimate of Post-Transplant Survival After Implementation of the New Donor Heart Allocation Policy
*Purpose: Published estimates showing lower post-transplant survival after implementation of the new heart allocation policy may be biased downward due to incomplete follow-up on surviving…2022 American Transplant Congress
TNX-1500, an Fc-Modified Anti-cd154 Antibody, Prolongs Nonhuman Primate Cardiac Allograft Survival
*Purpose: Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to replace current clinical immunosuppression. TNX-1500 (TNX) is a novel humanized anti-CD154…2022 American Transplant Congress
Ventricular Modeling Following Bariatric Surgery Decreases Need for Heart Transplantation
*Purpose: For obese patients with congestive heart failure (CHF), aggressive weight loss has been associated with ventricular remodeling. Many have suggested offering bariatric surgery for…2022 American Transplant Congress
Successful Use of Anti-IL-6R Therapy to Achieve Cardiac Allograft Tolerance in Non-Human Primates
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: In contrast to kidney allografts, attempts to achieve tolerance of isolated cardiac allografts in non-human primates (NHPs) using a mixed chimerism strategy have been…2022 American Transplant Congress
Estimating the Effect of Increased Donor Heart Ischemic Time on Post-Transplant Survival Using Instrumental Variables
*Purpose: Isolate the impact of organ ischemic time on post-transplant survival using the recent change in heart allocation policy as a natural experiment.*Methods: We examined…2022 American Transplant Congress
Outcome of Solid Organ Transplantation in Candidates with Intellectual Disability: A Systematic Review
Erasmus MC, Rotterdam, Netherlands
*Purpose: The allocation of organs comes with an ethical discussion in patients with intellectual disability. Historically, intellectual disability was considered a relative contra-indication for organ…2022 American Transplant Congress
The Role of Geography in Adult Heart Allocation Over the Last 5 Years
*Purpose: In the last 5 years two policies have impacted the role of geography in adult heart allocation including the 2018 adult heart policy which…2022 American Transplant Congress
Cd47 Expression on Transplanted Human Neonatal Mesenchymal Stem Cells Inhibits Phagocytosis in Rat Myocardial Infarction Model
Lurie Childrens Hospital, Chicago, IL
*Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal mesenchymal stem cells…2022 American Transplant Congress
Correlating Histology, Immunohistochemical, & Serologic Data in Heart Transplant Recipients: Implications for Molecular Diagnostic Assays
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: The ISHLT classification of rejection in heart allograft biopsies is independent of DSA status. There is only limited data on the prevalence of DSA…2022 American Transplant Congress
Significant Reduction of Troponin I Elaboration After Ischemia Minimization in the First Hour of Ex Vivo Xeno Heart Perfusion
*Purpose: Previous studies showed that ischemia minimization (IM), accomplished by perfusing the heart xenograft during storage, prevents ‘initial cardiac xenograft dysfunction’ (ICXD) and enables prolonged…
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