2022 American Transplant Congress
Analytical Evaluation and Comparison to STR of an Accurate and Sensitive Microchimerism Monitoring Tool for Liver Transplant Recipients
*Purpose: Peripheral blood chimerism is associated with clinically relevant events post liver transplantation (LT). Accurate quantification of donor chimerism in LT recipients with ultra-sensitive chimerism…2022 American Transplant Congress
Acute Graft versus Host Disease (AGVHD) Related to Solid Organ Transplant (SOT) – A Fatal Complication
1University of Cincinnati Medical Center, Cincinnati, OH, 2Hoxworth Blood Center, Cincinnati, OH
*Purpose: This case series highlights our institution's experience with solid-organ transplant (SOT) associated acute graft versus host disease (aGVHD), a rare and deadly complication of…2022 American Transplant Congress
Single-Cell RNA Sequencing Highlights the Role of Epithelial-Immune Dual Feature of Proximal Tubule Cells in BK Virus Nephropathy
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: BK virus nephropathy (BKVN) may cause renal allograft dysfunction and failure. However, a specific antiviral agent for BK virus does not exist. Increasing evidence…2022 American Transplant Congress
A Model of Idiopathic Pneumonia Syndrome in Rhesus Macaques
*Purpose: To create a model of idiopathic pneumonia syndrome (IPS), a deadly complication of hematopoietic stem cell transplantation (HSCT) in Rhesus macaques (RM).*Methods: RM were…2021 American Transplant Congress
Kidney Injury in Hematopoietic Cell Transplant (HCT) Recipients: Urinary Biomarkers to the Rescue
*Purpose: Kidney injury is common in HCT recipients and can be the result of graft versus host/kidney disease. However, this has not been well characterized,…2021 American Transplant Congress
A Case of Graft-versus-Host Disease Following Pancreas-Kidney Transplant
*Purpose: Graft-versus-host disease (GvHD) is an uncommon but often fatal complication following solid organ transplantation. It occurs when immunocompetent donor T cells are transferred to…2020 American Transplant Congress
Graft versus Host Disease in a Liver Transplant Patient
Department of Infectious Diseases, Baylor College of Medicine, Houston, TX
*Purpose: Graft versus host disease (GVHD) is a rare cause of morbidity and mortality in solid organ transplant (SOT) recipients; the estimated prevalence is 1-2%…2020 American Transplant Congress
Neonatal Tolerance Induction: Behaviours of Allogeneic Spleen and Bone Marrow Inocula in Neonatal Mice are Largely Determined by the Nature of Their CD8 T Cells
University of Alberta, Edmonton, AB, Canada
*Purpose: Injected adult allo-spleen (SC) and bone marrow cells (BMC) traffic to secondary lymphoid organs, proliferate and spread throughout neonatal mice; allo-SC consistently cause acute…2020 American Transplant Congress
Predictors and Outcomes of Acute Graft versus Host Disease after Liver Transplant
*Purpose: Graft-versus-Host Disease (GVHD) is a rare complication of liver transplant (LT) with an estimated incidence of 0.1-2% per year and a high mortality. There…2020 American Transplant Congress
A Recombinant, Fully Human ATG Polyclonal Antibody Drug Drives Immune Cell Depletion in a Model of Graft-versus-Host Disease
Immunology, GigaGen, South San Francisco, CA
*Purpose: Anti-thymocyte globulin (ATGs) are polyclonal antibody products that target and deplete T cells for immunosuppression in transplantation (prophylaxis of rejection). Since ATGs are derived…
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