2022 American Transplant Congress
Acute Graft versus Host Disease (AGVHD) Related to Solid Organ Transplant (SOT) – A Fatal Complication
1University of Cincinnati Medical Center, Cincinnati, OH, 2Hoxworth Blood Center, Cincinnati, OH
*Purpose: This case series highlights our institution's experience with solid-organ transplant (SOT) associated acute graft versus host disease (aGVHD), a rare and deadly complication of…2022 American Transplant Congress
Single-Cell RNA Sequencing Highlights the Role of Epithelial-Immune Dual Feature of Proximal Tubule Cells in BK Virus Nephropathy
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: BK virus nephropathy (BKVN) may cause renal allograft dysfunction and failure. However, a specific antiviral agent for BK virus does not exist. Increasing evidence…2022 American Transplant Congress
A Model of Idiopathic Pneumonia Syndrome in Rhesus Macaques
*Purpose: To create a model of idiopathic pneumonia syndrome (IPS), a deadly complication of hematopoietic stem cell transplantation (HSCT) in Rhesus macaques (RM).*Methods: RM were…2022 American Transplant Congress
Analytical Evaluation and Comparison to STR of an Accurate and Sensitive Microchimerism Monitoring Tool for Liver Transplant Recipients
*Purpose: Peripheral blood chimerism is associated with clinically relevant events post liver transplantation (LT). Accurate quantification of donor chimerism in LT recipients with ultra-sensitive chimerism…2021 American Transplant Congress
A Case of Graft-versus-Host Disease Following Pancreas-Kidney Transplant
*Purpose: Graft-versus-host disease (GvHD) is an uncommon but often fatal complication following solid organ transplantation. It occurs when immunocompetent donor T cells are transferred to…2021 American Transplant Congress
Kidney Injury in Hematopoietic Cell Transplant (HCT) Recipients: Urinary Biomarkers to the Rescue
*Purpose: Kidney injury is common in HCT recipients and can be the result of graft versus host/kidney disease. However, this has not been well characterized,…2020 American Transplant Congress
Predictors and Outcomes of Acute Graft versus Host Disease after Liver Transplant
*Purpose: Graft-versus-Host Disease (GVHD) is a rare complication of liver transplant (LT) with an estimated incidence of 0.1-2% per year and a high mortality. There…2020 American Transplant Congress
A Recombinant, Fully Human ATG Polyclonal Antibody Drug Drives Immune Cell Depletion in a Model of Graft-versus-Host Disease
Immunology, GigaGen, South San Francisco, CA
*Purpose: Anti-thymocyte globulin (ATGs) are polyclonal antibody products that target and deplete T cells for immunosuppression in transplantation (prophylaxis of rejection). Since ATGs are derived…2020 American Transplant Congress
Hematopoietic Cell Transplantation and Solid Organ Transplantation: Outcomes of Sequential Transplantation in the United States
*Purpose: Survival after solid organ transplantation(SOT) and hematopoietic cell transplantation(HCT) has steadily risen. Despite these improvements, SOT recipients may develop conditions requiring HCT, and HCT…2020 American Transplant Congress
Strong Engagement of CD137 Suppresses Graft-Versus-Host Disease Through Dendritic Cells
*Purpose: We previously demonstrated that anti-CD137 agonist prevent acute graft-versus-host disease (GVHD) and chronic GVHD in the parent-into-unirradiated F1 acute or chronic GVHD model. Although…
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