2019 American Transplant Congress
A Kidney Transplant Recipient with Severe Acute GvHD Promptly Rescued by Donor HLA-Targeted Serotherapy
*Purpose: Acute Graft-versus-Host Disease (GvHD) is a rare but frequently lethal complication after solid organ transplantation (SOT). In intestinal transplant recipients, anti-HLA Donor-Specific Antibody (DSA)…2019 American Transplant Congress
Central Role of Graft Resident Memory T Cells in Pathogenesis of GVHD after Bowel Transplantation
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Graft-versus-host disease (GVHD) is a relatively common and highly morbid complication after intestinal transplantation. Its pathophysiology remains poorly understood. Resident memory T cells (TRM)…2019 American Transplant Congress
Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation
*Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…2019 American Transplant Congress
Comparison of Tacrolimus or Cyclosporine Combined with Methotrexate for Graft versus Host Disease Prophylaxis after Allogeneic Hematopoietic Cell Transplantation: A Meta-Analysis
Transplant Center, Sun Yat-sen University, Guangzhou, China
*Purpose: After patients received hematopoietic stem cell transplantation (HSCT) ,both cyclosporine (CsA) and tacrolimus (TAC) in combination with methotrexate (MTX) have been recommended as standard…2019 American Transplant Congress
Differential Diagnosis of Membranous Nephropathy Occurs after Bone Marrow Transplantation and Renal Transplantation
*Purpose: Membranous nephropathy (MN), considered as a rare autoimmune kidney disease, often occurs in synchronization with manifestation of chronic graft-versus-host disease after transplantation. After bone…2019 American Transplant Congress
Donor Lymphocyte Chimerism and Homozygosity Are Critical Indicators for Timely and Accurate Diagnosis of Acute Graft vs. Host Disease after Liver Transplantation
Cleveland Clinic Foundation, Cleveland, OH
*Purpose: The mortality of Acute Graft vs. Host Disease (aGvHD) after Liver Transplantation (LT) can be greater than 85% due to delays in diagnosis and…2019 American Transplant Congress
First Report and Mechanistic Analysis of Chronic GVHD after Solid Organ Transplantation
Georgetown University Hospital, Washington, DC
*Purpose: Chronic graft-versus-host disease (cGVHD) occurs late after bone marrow transplantation and is associated with a characteristic lichenoid rash (cutaneous sclerosis) and effects on multiple…2019 American Transplant Congress
In Vivo/In Situ Behaviour of Allogeneic Spleen versus Bone Marrow Cells in Wild-Type Neonatal Mice: Insights into Robust Transplant Tolerance Induction
Pediatrics, University of Alberta, Edmonton, AB, Canada
*Purpose: Comparing the behaviour of fully allogeneic spleen (SC) vs bone marrow cells (BMC) in non-conditioned neonatal mice is important for maximizing synergistic interactions between…2019 American Transplant Congress
Superiority of Donor-Specifically vs. Polyclonally Expanded Regulatory T Cells in Controlling Graft Rejection in the NSG Mouse Human Skin Graft Model
*Purpose: Naturally occurring CD4+CD25highFOXP3+ Regulatory T cells (Tregs) function as mediators of immune homeostasis. So, they are beginning to be utilized for controlling hyper-immunity and…2018 American Transplant Congress
CD8+ Tissue Resident Memory T Cells Are Key Effector Cells in Intestinal Transplantation Patients with GvHD
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. As the pathophysiologic role of Tissue Resident Memory T Cells (TRM) in intestinal transplantation (ITx) is unknown, this study aims to test the hypothesis…
American Transplant Congress abstracts