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Articles tagged "Graft-versus-host-disease"

  • 2020 American Transplant Congress

    Graft versus Host Disease in a Liver Transplant Patient

    D. Francisco, L. Woc-Colburn, P. Nicholls, M. Hemmersbach-Miller

    Department of Infectious Diseases, Baylor College of Medicine, Houston, TX

    *Purpose: Graft versus host disease (GVHD) is a rare cause of morbidity and mortality in solid organ transplant (SOT) recipients; the estimated prevalence is 1-2%…
  • 2020 American Transplant Congress

    Neonatal Tolerance Induction: Behaviours of Allogeneic Spleen and Bone Marrow Inocula in Neonatal Mice are Largely Determined by the Nature of Their CD8 T Cells

    R. A. Bascom, K. Tao, L. J. West

    University of Alberta, Edmonton, AB, Canada

    *Purpose: Injected adult allo-spleen (SC) and bone marrow cells (BMC) traffic to secondary lymphoid organs, proliferate and spread throughout neonatal mice; allo-SC consistently cause acute…
  • 2020 American Transplant Congress

    Predictors and Outcomes of Acute Graft versus Host Disease after Liver Transplant

    A. Caines1, D. Moonka2, S. Nagai3, R. Salgia2

    1Gastroenterology and Hepatology, Henry Ford Health System, Detroit, MI, 2Hepatology, Henry Ford Health System, Detroit, MI, 3Transplant Surgery, Henry Ford Health System, Detroit, MI

    *Purpose: Graft-versus-Host Disease (GVHD) is a rare complication of liver transplant (LT) with an estimated incidence of 0.1-2% per year and a high mortality. There…
  • 2020 American Transplant Congress

    A Recombinant, Fully Human ATG Polyclonal Antibody Drug Drives Immune Cell Depletion in a Model of Graft-versus-Host Disease

    S. M. Keating, A. S. Adler, R. A. Mizrahi, J. Leong, M. A. Asensio, Y. W. Lim, A. R. Niedecken, Y. Chiang, R. Leong, D. S. Johnson

    Immunology, GigaGen, South San Francisco, CA

    *Purpose: Anti-thymocyte globulin (ATGs) are polyclonal antibody products that target and deplete T cells for immunosuppression in transplantation (prophylaxis of rejection). Since ATGs are derived…
  • 2020 American Transplant Congress

    Hematopoietic Cell Transplantation and Solid Organ Transplantation: Outcomes of Sequential Transplantation in the United States

    M. Gupta1, M. Levine2, D. Porter2, R. Brazauskas3, S. Bo-Subait4, R. Phelan3, M. Battiwalla5, D. Buchbinder6, B. Hamilton7, B. Shaw3, P. Abt2

    1University of Kentucky, Lexington, KY, 2University of Pennsylvania, Philadelphia, PA, 3Medical College of Wisconsin, Milwaukee, WI, 4CIBMTR, NMDP, Minneapolis, MN, 5Sarah Cannon Blood Cancer Network, Nashville, TN, 6Children's Hospital of Orange County, Orange, CA, 7Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH

    *Purpose: Survival after solid organ transplantation(SOT) and hematopoietic cell transplantation(HCT) has steadily risen. Despite these improvements, SOT recipients may develop conditions requiring HCT, and HCT…
  • 2020 American Transplant Congress

    Strong Engagement of CD137 Suppresses Graft-Versus-Host Disease Through Dendritic Cells

    H. Cho1, J. Lee2, B. Kwon3, S. Park4, H. Park4, K. Yoo2, K. Park2, J. Kim3, S. Kang3

    1Ulsan University Hospital, Ulsan, Korea, Republic of, 2Nephrology, Ulsan University Hospital, Ulsan, Korea, Republic of, 3Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, 4Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of

    *Purpose: We previously demonstrated that anti-CD137 agonist prevent acute graft-versus-host disease (GVHD) and chronic GVHD in the parent-into-unirradiated F1 acute or chronic GVHD model. Although…
  • 2020 American Transplant Congress

    CD137 Signaling in Regulatory Dendritic Cells Is Required for Suppressing a Systemic Inflammation in the bm12-Inducible Model of Systemic Lupus Erythematosus

    H. Cho1, J. Lee2, B. Kwon3, S. Park1, H. Park1, K. Yoo2, K. Park2, J. Kim3

    1Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of, 2Nephrology, Ulsan University Hospital, Ulsan, Korea, Republic of, 3Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of

    *Purpose: Although CD137 is well known as a costimulatory receptor in T cells, limited information is available for its immunoregulatory function. Here, we report that…
  • 2019 American Transplant Congress

    A Kidney Transplant Recipient with Severe Acute GvHD Promptly Rescued by Donor HLA-Targeted Serotherapy

    J. Zuber1, O. Boyer1, B. Neven1, R. Berthaud1, M. Ould Rabah1, I. Jollet2, V. Renac2, F. Pirenne2, S. Gross2, R. Djoudi2, P. Tiberghien2, J. Taupin3, S. Blanche1, R. Salomon1

    1Paris Descartes University, Paris, France, 2Etablissement Français du Sang, Paris, France, 3Department of Immunology and Histocompatibility, St Louis Hospital, Paris, France

    *Purpose: Acute Graft-versus-Host Disease (GvHD) is a rare but frequently lethal complication after solid organ transplantation (SOT). In intestinal transplant recipients, anti-HLA Donor-Specific Antibody (DSA)…
  • 2019 American Transplant Congress

    Central Role of Graft Resident Memory T Cells in Pathogenesis of GVHD after Bowel Transplantation

    J. Weiner, N. Svetlicky, J. Schmidt, S. Moturi, O. Aguirre, J. Kang, M. Sadat, K. Khan, J. Hawksworth, C. Matsumoto, T. Fishbein, A. Kroemer

    MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Graft-versus-host disease (GVHD) is a relatively common and highly morbid complication after intestinal transplantation. Its pathophysiology remains poorly understood. Resident memory T cells (TRM)…
  • 2019 American Transplant Congress

    Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation

    N. Navarro-Alvarez1, A. R. Andrews1, Z. DeFilipp2, Y. A. Chen2, V. T. Ho3, J. Ritz3, T. R. Spitzer4, C. A. Huang5

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, 3Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, 4Hematology/Oncology, Massachusetts General Hospital, Boston, MA, 5Plastic & Reconstructive Surgery and Transplant Surgery Divisions, University of Colorado, Denver, Aurora, CO

    *Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…
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