2021 American Transplant Congress
A Case of Graft-versus-Host Disease Following Pancreas-Kidney Transplant
*Purpose: Graft-versus-host disease (GvHD) is an uncommon but often fatal complication following solid organ transplantation. It occurs when immunocompetent donor T cells are transferred to…2021 American Transplant Congress
Kidney Injury in Hematopoietic Cell Transplant (HCT) Recipients: Urinary Biomarkers to the Rescue
*Purpose: Kidney injury is common in HCT recipients and can be the result of graft versus host/kidney disease. However, this has not been well characterized,…2020 American Transplant Congress
Graft versus Host Disease in a Liver Transplant Patient
Department of Infectious Diseases, Baylor College of Medicine, Houston, TX
*Purpose: Graft versus host disease (GVHD) is a rare cause of morbidity and mortality in solid organ transplant (SOT) recipients; the estimated prevalence is 1-2%…2020 American Transplant Congress
Neonatal Tolerance Induction: Behaviours of Allogeneic Spleen and Bone Marrow Inocula in Neonatal Mice are Largely Determined by the Nature of Their CD8 T Cells
University of Alberta, Edmonton, AB, Canada
*Purpose: Injected adult allo-spleen (SC) and bone marrow cells (BMC) traffic to secondary lymphoid organs, proliferate and spread throughout neonatal mice; allo-SC consistently cause acute…2020 American Transplant Congress
Predictors and Outcomes of Acute Graft versus Host Disease after Liver Transplant
*Purpose: Graft-versus-Host Disease (GVHD) is a rare complication of liver transplant (LT) with an estimated incidence of 0.1-2% per year and a high mortality. There…2020 American Transplant Congress
A Recombinant, Fully Human ATG Polyclonal Antibody Drug Drives Immune Cell Depletion in a Model of Graft-versus-Host Disease
Immunology, GigaGen, South San Francisco, CA
*Purpose: Anti-thymocyte globulin (ATGs) are polyclonal antibody products that target and deplete T cells for immunosuppression in transplantation (prophylaxis of rejection). Since ATGs are derived…2020 American Transplant Congress
Hematopoietic Cell Transplantation and Solid Organ Transplantation: Outcomes of Sequential Transplantation in the United States
*Purpose: Survival after solid organ transplantation(SOT) and hematopoietic cell transplantation(HCT) has steadily risen. Despite these improvements, SOT recipients may develop conditions requiring HCT, and HCT…2020 American Transplant Congress
Strong Engagement of CD137 Suppresses Graft-Versus-Host Disease Through Dendritic Cells
*Purpose: We previously demonstrated that anti-CD137 agonist prevent acute graft-versus-host disease (GVHD) and chronic GVHD in the parent-into-unirradiated F1 acute or chronic GVHD model. Although…2020 American Transplant Congress
CD137 Signaling in Regulatory Dendritic Cells Is Required for Suppressing a Systemic Inflammation in the bm12-Inducible Model of Systemic Lupus Erythematosus
*Purpose: Although CD137 is well known as a costimulatory receptor in T cells, limited information is available for its immunoregulatory function. Here, we report that…2019 American Transplant Congress
A Kidney Transplant Recipient with Severe Acute GvHD Promptly Rescued by Donor HLA-Targeted Serotherapy
*Purpose: Acute Graft-versus-Host Disease (GvHD) is a rare but frequently lethal complication after solid organ transplantation (SOT). In intestinal transplant recipients, anti-HLA Donor-Specific Antibody (DSA)…
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