Articles tagged "Graft survival"

2016 American Transplant Congress
HLA Antibody in Transplant Recipients During Transition from Paediatrics.
S. Kaki,¹ A. Lunn,² J. Goodwin,³ T. Key,³ W. McKane.¹
¹Renal, Sheffield Kidney Institute, Sheffield, United Kingdom; ²Renal, Queens Medical Centre, Sheffield, United Kingdom; ³Histocompatibility and Immunogenetics, National Health Service blood and transplantation, Sheffield, United Kingdom.
Objective:Adolescent transplant recipients in transition from paediatric to adult units are known to be at high risk of graft failure. Detection of HLA antibody is…
2016 American Transplant Congress
Outcomes of Solid Organ Transplants Following Simultaneous Solid Organ and Vascularized Composite Allograft Procurements.
M. Alhefzi,¹ M. Aycart,¹ G. Sharma,² N. Krezdorn,¹ E. Bueno,¹ S. Talbot,¹ M. Carty,¹ B. Pomahac,¹ S. Tullius.³
¹Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ³Department of Surgery, Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Background: Current knowledge of the impact of facial vascularized composite allograft (VCA) procurement on the transplantation outcomes of the concomitantly recovered life-saving organs is limited…
2016 American Transplant Congress
Development of Diabetic Glomerulosclerosis (DMGS) After Kidney Transplantation (KTX).
F. Cosio, L. Cornell, M. Stegall.
Transplant Center, Mayo Clinic, Rochester, MN.
Introduction. Causes of death-censored KTX loss are multiple and often non-alloimmune mediated. Examination of KTX biopsies after 5 years revealed an increasing number of cases…
2016 American Transplant Congress
Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells.
M. Uchiyama,^1,2 E. Yin,^2,3 X. Jin,^2,4 T. Shimokawa,¹ H. Yagita,⁵ M. Niimi.²
¹Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ²Surgery, Teikyo University, Tokyo, Japan; ³Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ⁴Thoracic Surgery, The 3rd Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Immunology, Juntendo University Hospital, Tokyo, Japan.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
2016 American Transplant Congress
The Impact of Kidney Donor Profile Index (KDPI) on Rates of Delayed Graft Function (DGF).
T. Zens, G. Leverson, R. Redfield, P. Chlebeck, L. Zitur, D. Kaufman, L. Fernandez.
Surgery, University of Wisconsin, Madison, WI.
Introduction: Delayed graft function (DGF) is the need for dialysis within the first 7 days after kidney transplantation. Immunologic and non-immunologic donor and recipient factors…
2016 American Transplant Congress
Does Donor and Recipient Age Disparity Make a Difference with Expanded Criteria Donors?
M. Khan,¹ K. Jones,¹ H. El-Hennawy,¹ A. Farney,¹ J. Rogers,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² M. Gautreaux,³ S. Iskandar,³ W. Doares,⁴ S. Kaczmorski,⁴ R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC; ³Pathology, Wake Forest, Winston-Salem, NC; ⁴Pharmacy, Wake Forest, Winston-Salem, NC.
The critical shortage of donor organs challenges the transplant community to optimize the use of organs from all consented deceased donors (DD). The purpose of…
2016 American Transplant Congress
The Impact of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx) Is Independent of Time Post-Transplant.
R. Gaston,¹ J. Grande,² R. Leduc,³ The DeKAF Study Group.
¹Dept. of Medicine, University of Alabama at Birmingham, Birmingham, AL; ²Dept of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; ³Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.
Detection of MVI in a KTxBx, often associated with antibody mediated rejection, is associated with a poor prognosis for kidney graft survival. However most information…
2016 American Transplant Congress
Development of a Vascularized Thymus-Sternum Composite Tissue Allograft Model in Non-Human Primates.
N. O'Neill, S. Sendil, Y. Zhao, A. Hershfield, I. Tatarov, G. Braileanu, W. Hassanein, D. Parsell, A. Azimzadeh, L. Burdorf, R. Pierson, A. Nam.
Surgery, University of Maryland, Baltimore, MD.
Purpose: Vascularized composite allotransplantation (VCA) has demonstrated clinical success with standard immunosuppressive strategies in face, hand, and forearm transplantations. We developed a non-human primate model…
2016 American Transplant Congress
Inhibitory FcγRIIB Functionally Inhibits Donor-Reactive CD8⁺ Memory T Cell Responses Following Transplantation.
D. Pinelli, M. Wagener, D. Liu, I. Badell, M. Ford.
Emory Transplant Center, Emory University, Atlanta, GA.
Fc receptors are expressed by many types of immune cells and bind to the constant portion of immunoglobulin to mediate their effector functions. The inhibitory…
2016 American Transplant Congress
DSA After Transplant Increases Risk of Renal Allograft Failure Independent of Concurrent Biopsy Results: The DEKAF Study Data.
J. Cecka,¹ J. Grande,² F. Cosio,² R. Leduc,³ The DeKAF Study Group.
¹UCLA Immunogenetics Center Department of Pathology, University of California-Los Angeles, Los Angeles, CA; ²Department of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; ³Department of Biostatistiscs, University of Minnesota School of Public Health, Minneapolis, MN.
Donor-specific HLA antibodies (DSA) are a major cause of renal allograft dysfunction and loss following transplant. The presence of DSA, with or without C4d deposition,…