ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Does Donor and Recipient Age Disparity Make a Difference with Expanded Criteria Donors?

M. Khan,1 K. Jones,1 H. El-Hennawy,1 A. Farney,1 J. Rogers,1 G. Orlando,1 A. Reeves-Daniel,2 A. Palanisamy,2 M. Gautreaux,3 S. Iskandar,3 W. Doares,4 S. Kaczmorski,4 R. Stratta.1

1Surgery, Wake Forest, Winston-Salem, NC
2Internal Medicine, Wake Forest, Winston-Salem, NC
3Pathology, Wake Forest, Winston-Salem, NC
4Pharmacy, Wake Forest, Winston-Salem, NC.

Meeting: 2016 American Transplant Congress

Abstract number: C77

Keywords: Allocation, Donors, Graft survival, Kidney transplantation, marginal

Session Information

Date: Monday, June 13, 2016

Session Name: Poster Session C: Economics, Public Policy, Allocation, Ethics

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • Analysis of Local versus Imported Expanded Criteria Donor (ECD) Kidneys: A Single Center Experience with 497 ECD Kidney Transplants.
  • Standardized Pre-Implantation Kidney Biopsies of Expanded Criteria Donors to Improve the Kidney Donor Profile Index (KDPI) for the Evaluation of Marginal Donors.

The critical shortage of donor organs challenges the transplant community to optimize the use of organs from all consented deceased donors (DD). The purpose of this study was to review our experience with expanded criteria donor (ECD) kidney transplants (KT) with respect to donor and recipient age differences. Methods: We performed a single center retrospective analysis in adult DD KT patients (pts). >80% of ECD kidneys were managed with machine preservation. All pts received depleting antibody induction with FK/mycophenolate. Delayed graft function (DGF) was defined as the need for hemodialysis for any reason in the 1st week following transplant. Results: From 10/01 to 7/14, our center performed 497 ECD KTs, of which 423 occurred with a donor/recipient age disparity of ≤15 years (age-matched) whereas the remaining 74 occurred with an age disparity >15 years (age-mismatched). With a mean follow-up of 62 months (minimum 1 year), there were no differences in patient survival (72.6% vs 71.6%), death with a functioning graft (17.5% vs 18.9%), or DGF (25.8% vs 28.4%) rates in the age-matched vs mismatched groups, respectively. However, actual graft survival (GS, 59.1% vs 43.2%, p=0.015) and death-censored graft survival (DCGS, 71.6% vs 53.3%, p=0.006) rates were significantly higher in age-matched vs mismatched groups, respectively. We next analyzed ECD KT outcomes according to distinct recipient age categories (40-59, 60-69, and ≥70); kidney GS and DCGS rates improved (p<0.05) with increasing recipient age category. Conclusions: The new Kidney Allocation System attempts to eliminate extreme age mismatches between donor and recipient in order to match graft lifespan with recipient life expectancy. In addition, however, the above findings suggest that the optimal use of an ECD kidney is to match donor and recipient age in order to improve graft survival rates.

CITATION INFORMATION: Khan M, Jones K, El-Hennawy H, Farney A, Rogers J, Orlando G, Reeves-Daniel A, Palanisamy A, Gautreaux M, Iskandar S, Doares W, Kaczmorski S, Stratta R. Does Donor and Recipient Age Disparity Make a Difference with Expanded Criteria Donors? Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Khan M, Jones K, El-Hennawy H, Farney A, Rogers J, Orlando G, Reeves-Daniel A, Palanisamy A, Gautreaux M, Iskandar S, Doares W, Kaczmorski S, Stratta R. Does Donor and Recipient Age Disparity Make a Difference with Expanded Criteria Donors? [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/does-donor-and-recipient-age-disparity-make-a-difference-with-expanded-criteria-donors/. Accessed March 4, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.