ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft survival"

  • 2017 American Transplant Congress

    Three Induction Therapies on Patients with Delayed Graft Function After Kidney Transplantation, a Three-Year Outcome Analysis.

    A. Umber, M. Killackey, A. Paramesh, B. Alper, F. Teran, A. Baudy, Y. Liu, J. Buell, R. Zhang.

    Departments of Medicine and Surgery, Tulane University School of Medicine, New Orleans, LA

    We compare the 3-year outcomes of induction therapies with either methylprednisolone (group 1, n=58), basiliximab (group 2, n=56) or alemtuzumab (group 3, n=98) in primary…
  • 2017 American Transplant Congress

    A Composite Score Associated with Spontaneous Operational Tolerance in Kidney Transplant Recipients.

    R. Danger,1 M. Chesneau,1 C. Paul,1 P. Guérif,1 M. Durand,1 K. Newell,2 S. Kanaparthi,3 L. Turka,4 J.-P. Soulillou,1 R. Houlgatte,5 M. Giral,1,6 G. Ramstein,7 S. Brouard.1,6

    1Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; 2Department of Surgery, Emory University, Atlanta, GA; 3Immune Tolerance Network, Bethesda, MD; 4Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 5INSERM UMR 954,CHU de Nancy, DRCI, Nancy, France; 6CIC Biotherapy, CHU Nantes, Nantes, France; 7LINA DUKe, UMR 6241, Université de Nantes, Ecole des Mines de Nantes & CNRS, Nantes, France

    New challenges in renal transplantation include using biological information to devise a useful clinical test for discerning high- and low-risk patients for individual therapy and…
  • 2017 American Transplant Congress

    Donor Creatinine and Graft Outcomes in Pediatric Kidney Transplant Recipients.

    N. Hayde, M. Del Rio.

    Montefiore Medical Center, Bronx, NY

    Background: The role of donor peak and terminal creatinine on short and long term allograft outcomes in pediatric kidney transplant recipients is unclear.Aim: To determine…
  • 2017 American Transplant Congress

    Regulation of T Cell Migration by Specifically Targeting Lymphotoxin β Receptor (LTβR)-Mediated Non-Canonical NFkB Signaling.

    W. Piao, Y. Xiong, C. Brinkman, J. Bromberg.

    UMB, Baltimore

    Background:Selective recruitment of regulatory T cells (Treg) to draining lymph nodes is crucial for graft survival, and LTαβ-LTβR signaling is required to direct Treg into…
  • 2017 American Transplant Congress

    Outcome of Living Donor Transplantation in Pediatric Recipients Over the Last Three Decades by Era: An Analysis of UNOS Database.

    V. Whittaker, M. Laftavi, Z. Acun, R. Gruessner, A. Gruessner.

    Surgery, State University New York, Syracuse, NY

    Background: Living donor is the potential solution to organ shortage. This retrospective analysis of UNOS database evaluates the outcome of living donor transplantation across 4…
  • 2017 American Transplant Congress

    Analysis of Outcomes in High Risk Kidney Transplants.

    E. Liu, M. Aull, J. Lee, S. Kapur.

    Kidney and Pancreas Transplantation, NewYork-Presbyterian Weill Cornell Medical Center, New York, NY

    Background: The new kidney allocation system implemented in 12/2014 utilizes estimated post-transplant survival scores (EPTS) and kidney donor profile index (KDPI) to optimize recipient survival…
  • 2017 American Transplant Congress

    Dual Treatment of Suboptimal Doses of CsA and MSC Infusion Fully Prevents Acute Rejection in an Allogenic Model of Renal Transplantation.

    L. de Ramon,1 A. Merino,1 E. Ripoll,1 N. Bolaños,1 M. Gomà,3 J. Cruzado,1,2 J. Grinyó,1,2 J. Torras.1,2

    1Experimental Nephrology, IDIBELL-UB, Hospitalet Llobregat, Barcelona, Spain; 2Nephrology, Hospital Universitari de Bellvitge, Hospitalet Llobregat, Barcelona, Spain; 3Pathology, Hospital Universitari de Bellvitge, Hopitalet Llobregat, Barcelona, Spain

    The immunomodulatory characteristics of mesenchymal stem cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate the…
  • 2017 American Transplant Congress

    New Approach for Targeted Immunotherapy in Vascularized Composite Allotransplantation.

    F. Feturi,1 H. Wang,2 Y. Brudno,2 V. Erbas,3 Z. Zhang,3 H. Sahin,3 D. Mooney,2 V. Gorantla,3 R. Venkataramanan.1

    1Department of Pharmaceutical Science, University of Pittsburgh School of Pharmacy, Pittsburgh, PA; 2A Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA; 3Department of Plastic and Reconstructive Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Vascularized composite allotransplantation (VCA) have highly immunogenic skin component mandates high doses of systemic immunosuppressive drugs. Oral dosing leads to fluctuating, unpredictable blood levels that…
  • 2017 American Transplant Congress

    mTORC1 and 2 Regulate Dendritic Cell (DC) Metabolism and Allostimulatory Function of Donor DCs in Skin Transplantation.

    A. Watson,1,2 H. Dai,1,3 A. Menk,4,5 G. Delgoffe,4,5 A. Thomson.1,2,3

    1Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh; 2Pathology, Univ. of Pittsburgh, Pittsburgh; 3Surgery, Univ. of Pittsburgh, Pittsburgh; 4Immunology, Univ. of Pittsburgh, Pittsburgh; 5Cancer Institute, Univ. of Pittsburgh, Pittsburgh

    Background/Hypothesis: The mechanistic target of rapamycin (mTOR) is a kinase that functions in two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play critical…
  • 2017 American Transplant Congress

    Complications Requiring Reoperation After Pediatric Liver Transplantation.

    D. Yoeli, J. Moffett, K. Hosek, R. Ackah, R. Sigireddi, M. Kueht, N. Galvan, R. Cotton, A. Rana, C. O'Mahony, J. Goss.

    Department of Surgery, Baylor College of Medicine, Houston, TX

    Context: Reoperative complications after liver transplantation have been shown to decrease patient and graft survival in adults; this effect, however, has not been studied in…
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