Date: Tuesday, May 2, 2017
Session Time: 2:30pm-4:00pm
Presentation Time: 3:18pm-3:30pm
Background: Living donor is the potential solution to organ shortage. This retrospective analysis of UNOS database evaluates the outcome of living donor transplantation across 4 era and report the results in the pediatric population.
Methods: Retrospective analysis of all pediatric living donor transplantation in the U.S. 1987- 2015. The era were: 1987-1994, 1995-2001, 2002-2008 and 2009-2015. The outcome pediatric transplant recipients were then analyzed. Test of equality over strata by Log Rank and Wilcoxon Statistics was used for data analysis. P value of <0.05 was considered significant.
Results: Total: 9005. Significant improvement in graft survival with each successive Cohort. 5 year outcomes: 73.69, 80.9, 82.6, and 87.7% graft survival. At 10 years: graft survival rates 55%, second era 60.4%, and the third era 66% graft survival.
|Era||Graft Survival ( years)
The late outcome at 25 years in the first era 10.58. Median age 12, 12, 12, 11 with each successive era, donor age 36, 37, 37, years respectively. Biological relatedness: 98.6, 95.3, 88.5 and79.7%. T50% Living vs DD 11.3 vs 6.6, 12.7 vs 9, >13 vs 9.6 years in each successive era.
Significant improvement in graft survival in living donor transplants pediatric population. Based on half life, they remain a good choice for pediatric patients. Improved care and advances in immunosuppressive therapies likely resulted in the outcome. Opportunities for improved graft survival still exist for the long term.
CITATION INFORMATION: Whittaker V, Laftavi M, Acun Z, Gruessner R, Gruessner A. Outcome of Living Donor Transplantation in Pediatric Recipients Over the Last Three Decades by Era: An Analysis of UNOS Database. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Whittaker V, Laftavi M, Acun Z, Gruessner R, Gruessner A. Outcome of Living Donor Transplantation in Pediatric Recipients Over the Last Three Decades by Era: An Analysis of UNOS Database. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/outcome-of-living-donor-transplantation-in-pediatric-recipients-over-the-last-three-decades-by-era-an-analysis-of-unos-database/. Accessed October 29, 2020.
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