ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft survival"

  • 2018 American Transplant Congress

    Comparison of Low Dose and Very Low Dose Extended-Release Tacrolimus / MMF in De Novo Kidney Transplant Recipients- 3 Years Follow-Up

    S. Narumi,1 Y. Watarai,1 N. Goto,2 T. Hiramitsu,1 M. Tsujita,2 M. Okada,1 K. Futamura,2 T. Kobayashi.3

    1Transplant Surgery, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan; 2Transplant Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan; 3Kidney Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.

    Recently, once-daily tacrolimus extended-release formulation (TACER) has been accepted in kidney transplantation, however its optimal dosing are not well evaluated. We have validated low dose…
  • 2018 American Transplant Congress

    A Natural Herb Danshen Suppresses Allospecific Memory CD8+ T Cell Generation and Murine Allograft Rejection

    Z. Dai, H. Liu, Y. Chen, C-.L. Liang, F. Qiu.

    Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.

    Inducing long-term transplant survival or tolerance without continuous global immunosuppression is a highly desired goal in transplantation given that conventional immunosuppressive drugs may cause side…
  • 2018 American Transplant Congress

    Elevated Donor Terminal Creatinine Does Not Appear to Be Associated with Worse Outcomes in Kidney Transplantation

    S. Rayhill, J. Haldorson.

    U Washington, Seattly.

    There is justified reluctance to use kidneys from donors with significantly elevated creatinine as they may have severe, irreversible injury. Recently, thanks, in part to…
  • 2017 American Transplant Congress

    Regulation of T Cell Migration by Specifically Targeting Lymphotoxin β Receptor (LTβR)-Mediated Non-Canonical NFkB Signaling.

    W. Piao, Y. Xiong, C. Brinkman, J. Bromberg.

    UMB, Baltimore

    Background:Selective recruitment of regulatory T cells (Treg) to draining lymph nodes is crucial for graft survival, and LTαβ-LTβR signaling is required to direct Treg into…
  • 2017 American Transplant Congress

    Outcome of Living Donor Transplantation in Pediatric Recipients Over the Last Three Decades by Era: An Analysis of UNOS Database.

    V. Whittaker, M. Laftavi, Z. Acun, R. Gruessner, A. Gruessner.

    Surgery, State University New York, Syracuse, NY

    Background: Living donor is the potential solution to organ shortage. This retrospective analysis of UNOS database evaluates the outcome of living donor transplantation across 4…
  • 2017 American Transplant Congress

    Analysis of Outcomes in High Risk Kidney Transplants.

    E. Liu, M. Aull, J. Lee, S. Kapur.

    Kidney and Pancreas Transplantation, NewYork-Presbyterian Weill Cornell Medical Center, New York, NY

    Background: The new kidney allocation system implemented in 12/2014 utilizes estimated post-transplant survival scores (EPTS) and kidney donor profile index (KDPI) to optimize recipient survival…
  • 2017 American Transplant Congress

    Dual Treatment of Suboptimal Doses of CsA and MSC Infusion Fully Prevents Acute Rejection in an Allogenic Model of Renal Transplantation.

    L. de Ramon,1 A. Merino,1 E. Ripoll,1 N. Bolaños,1 M. Gomà,3 J. Cruzado,1,2 J. Grinyó,1,2 J. Torras.1,2

    1Experimental Nephrology, IDIBELL-UB, Hospitalet Llobregat, Barcelona, Spain; 2Nephrology, Hospital Universitari de Bellvitge, Hospitalet Llobregat, Barcelona, Spain; 3Pathology, Hospital Universitari de Bellvitge, Hopitalet Llobregat, Barcelona, Spain

    The immunomodulatory characteristics of mesenchymal stem cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate the…
  • 2017 American Transplant Congress

    New Approach for Targeted Immunotherapy in Vascularized Composite Allotransplantation.

    F. Feturi,1 H. Wang,2 Y. Brudno,2 V. Erbas,3 Z. Zhang,3 H. Sahin,3 D. Mooney,2 V. Gorantla,3 R. Venkataramanan.1

    1Department of Pharmaceutical Science, University of Pittsburgh School of Pharmacy, Pittsburgh, PA; 2A Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA; 3Department of Plastic and Reconstructive Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Vascularized composite allotransplantation (VCA) have highly immunogenic skin component mandates high doses of systemic immunosuppressive drugs. Oral dosing leads to fluctuating, unpredictable blood levels that…
  • 2017 American Transplant Congress

    mTORC1 and 2 Regulate Dendritic Cell (DC) Metabolism and Allostimulatory Function of Donor DCs in Skin Transplantation.

    A. Watson,1,2 H. Dai,1,3 A. Menk,4,5 G. Delgoffe,4,5 A. Thomson.1,2,3

    1Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh; 2Pathology, Univ. of Pittsburgh, Pittsburgh; 3Surgery, Univ. of Pittsburgh, Pittsburgh; 4Immunology, Univ. of Pittsburgh, Pittsburgh; 5Cancer Institute, Univ. of Pittsburgh, Pittsburgh

    Background/Hypothesis: The mechanistic target of rapamycin (mTOR) is a kinase that functions in two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play critical…
  • 2017 American Transplant Congress

    Complications Requiring Reoperation After Pediatric Liver Transplantation.

    D. Yoeli, J. Moffett, K. Hosek, R. Ackah, R. Sigireddi, M. Kueht, N. Galvan, R. Cotton, A. Rana, C. O'Mahony, J. Goss.

    Department of Surgery, Baylor College of Medicine, Houston, TX

    Context: Reoperative complications after liver transplantation have been shown to decrease patient and graft survival in adults; this effect, however, has not been studied in…
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