ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft survival"

  • 2018 American Transplant Congress

    Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses Acute Allograft Rejection and Prolongs Graft Survival in Murine Heart Transplantation

    T. Tanaka, T. Maehana, N. Masumori.

    Department of Urology, Sapporo Medical University, Sapporo, Japan.

    Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor to recipients prolonged the allograft survival in murine skin and…
  • 2018 American Transplant Congress

    Kidney Transplantation from Uncontrolled Donation after Circulatory Death, Good Outcomes after Very Long Time

    M. Molina,1 J. Cabrera,2 E. Gonzalez,1 A. Hernandez,1 P. Natalia,1 A. Andres.1

    1Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain; 2Department of Nephrology, Hospital Evangelico, Montevideo, Uruguay.

    Introduction: Kidney transplantation (KT) is the best renal replacement therapy but the shortage of organ is the main limitation. Uncontrolled Donation after Circulatory Death (uDCD)…
  • 2018 American Transplant Congress

    Impacts of HBsAg Seropositive Status on Patient and Graft Survival after Kidney Transplantation in the Era of New Antiviral Therapy: A Meta-Analysis

    N. Leeaphorn,1 C. Thongprayoon,2 K. Sharma,2 A. Sakhuja,3 W. Cheungpasitporn.4

    1Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA; 2Department of Medicine, Bassett Medical Center, Cooperstown, NY; 3Department of Medicine, Mayo Clinic, Rochester, MN; 4Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS.

    BACKGROUND: An association between HBsAg seropositive status and increased mortality after kidney transplantation has been demonstrated in previous studies over the past decade. Although chronic…
  • 2018 American Transplant Congress

    Screening of RhoA/ROCK Inhibitors for the Ability to Prevent Chronic Rejection of Mouse Cardiac Allografts

    W. Chen, W. Chen, X. Li, R. Ghobrial, M. Kloc.

    THMRI, Houston, TX.

    Objectives. Chronic rejection of transplanted organs is a major obstacle in human organ transplantation. Although the mechanisms of chronic rejection are poorly understood it is…
  • 2018 American Transplant Congress

    Memory T Cell Dysfunction after Pregnancy Alloimmunization Prolongs Transplant Survival

    P. Porrett,1 J. Cohen,2 R. Xu,1 E. Lewis,3 M. Elovitz,3 E. Wherry,4 D. Sawinski.2

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Medicine, University of Pennsylvania, Philadelphia, PA; 3OBGyn, University of Pennsylvania, Philadelphia, PA; 4Microbiology, University of Pennsylvania, Philadelphia, PA.

    Background Pregnancy alloimmunization can preclude donor compatibility and may diminish transplant lifespan. While these consequences may be attributed to immunologic memory responses that endanger an…
  • 2018 American Transplant Congress

    Development of Denovo DSA after One Year Post Kidney Transplant and Clinical Outcomes in Patient on Steroid Free Immunosupression

    A. Sharfuddin, M. Yaqub, D. Mishler, W. Goggins, T. Taber, O. Adebiyi.

    Division of Renal Disease and Hypertension, Indiana University Health Transplant Program, Indianapolis, IN.

    Background: Development of Denovo donor specific antibodies (DnDSA) has been associated with poor allograft outcomes in few studies. However, there is scarcity of data evaluating…
  • 2018 American Transplant Congress

    Lymphotoxin Beta Receptor Modulation in Lymphatic Endothelial Cells Alters Regulatory T Cell Dynamics

    V. Saxena, W. Piao, Y. Xiong, L. Li, C. Wagner, J. Bromberg.

    U Maryland, Baltimore, MD.

    Background:Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels (LV)…
  • 2018 American Transplant Congress

    Parathyroidectomy Outcomes in Renal Transplant Recipients: Subtotal vs. Total

    R. Rathore,1,2 A. Sharma,2 A. Halawa.2

    1Renal Medicine, University Hospitals of North Midlands, Stoke-on-Trent, United Kingdom; 2Faculty of Health, University of Liverpool, Liverpool, United Kingdom.

    Introduction:Best practice in management of persistent hyperparathyroidism in renal transplant recipients has been debated and there is no consensus on whether medical or surgical management…
  • 2018 American Transplant Congress

    Prolongation of Skin Allograft Survival through Dietary Supplementation of Ayrl Hydrocarbon Receptor Ligands

    A. Afrazi, L. Owens, J. Fechner, C. O'Driscoll, J. Mezrich.

    Transplant Surgery, University of Wisconsin, Madison, WI.

    The Aryl Hydrocarbon Receptor (AHR) is a cytosolic transcription factor with numerous endogenous and xenobiotic ligands playing a key role in a number of cellular…
  • 2018 American Transplant Congress

    AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine Model

    B. Swearingen,1,2 S. Graves,2,3 R. Storb,2,3 D. Mathes.1,2

    1Surgery; Division of Plastic and Reconstructive Surgery, University of Colorado School of Medicine, Aurora, CO; 2Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 3Medicine, University of Washington Medical Center, Seattle, WA.

    PURPOSE:Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by chronic immunosuppression and rejection. Current clinical tolerance protocols rely on recipient conditioning and…
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