Articles tagged "Graft survival"

2018 American Transplant Congress
The Impact of Donor Specific Alloantibodies on Long-Term Outcomes of Liver Re-Transplantation
Q. Xu,¹ A. Skaro,² V. McAlister.²
¹Department of Pathology and Lab Medicine, University of Western Ontario, London, ON, Canada; ²Department of Surgery, University of Western Ontario, London, ON, Canada.
Despite reports that associate donor specific antibody (DSA) with rejection after liver transplantation, grafts are still allocated according to blood group (ABO) but not human…
2018 American Transplant Congress
Novel Vascular Inflow Offers Renal Transplantation to Recipients with Severe Central and Peripheral Vascular Disease
S. Mao,¹ E. Giorgakis,² A. Moss,² T. Taner.¹
¹William J. von Liebig Center for Transplantation, Mayo Clinic, Rochester, MN; ²Transplantation Surgery, Mayo Clinic, Phoenix, AZ.
Background: Absence of suitable implant locations for donor renal vessels may be a major problem in patients with significant central and peripheral vascular disease. We…
2018 American Transplant Congress
Lymph Node Stromal Laminins Affect Graft Survival through Regulation of CD4 T Cell Proliferation and Migration
L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.
University of Maryland, Baltimore, MD.
Background: Our prior studies demonstrated that tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511),…
2018 American Transplant Congress
Sensing T Cell Killing Activity with Granzyme B Activity Probes
Q. Mac,¹ D. Mathews,² J. Kahla,¹ C. Stoffers,¹ O. Delmas,¹ B. Holt,¹ A. Adams,² G. Kwong.¹
¹Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; ²Department of Surgery, Emory University School of Medicine, Atlanta, GA.
Purpose: We developed activity-based probes that sense Granzyme B (GzmB) activity during alloreactive T cell killing of donor cellsMethods: FITC-labelled GzmB substrate (IEFDSG) was synthesized…
2018 American Transplant Congress
Rejection and Graft Loss in Patients with BK Viremia after Simultaneous Pancreas and Kidney Transplant
D. Keys, S. Riad, V. Vakil, S. Jackson, D. Berglund, A. Matas, R. Kandaswamy.
University of Minnesota, Minneapolis, MN.
Background: BK virus is a recognized cause of kidney allograft dysfunction. The treatment of BK is immunosuppression reduction. This reduction in patients with a simultaneous…
2018 American Transplant Congress
Patient and Transplant Outcome in Infants Starting Renal Replacement Therapy before Two Years of Age
J. Hogan,^1,2,3 J. Harambat,⁴ E. Berard,⁵ C. Couchoud,³ M-.A. Macher.^2,3
¹Pediatric Nephrology, Emory University, Atlanta, GA; ²Pediatric Nephrology, Robert Debre University Hospital, Paris, France; ³REIN Registry, French Biomedecine Agency, Paris, France; ⁴Pediatric Nephrology, Bordeaux University Hospital, Bordeaux, France; ⁵Pediatric Nephrology, L'archet Hospital, Nice, France.
Introduction: Despite major technical improvement in the care of children requiring renal replacement therapy (RRT) before two years of age, the management of those patients…
2018 American Transplant Congress
Excellent Long-Term Outcomes with Kidney Transplants from Deceased Donors with Acute Kidney Injury
G. Dube, S. Husain, D. Cohen, S. Mohan.
Medicine, Columbia University Medical Center, New York, NY.
Kidney transplants (KT) from donors with acute kidney injury (AKI; terminal creatinine ≥ 2.0) are increasingly performed and have similar short-term outcomes compared with KT…
2018 American Transplant Congress
Incidence of BK Viraemia and BK Virus Associated Nephropathy with Standard vs. Augmented Immunosuppression
R. Rathore, S. Anastassiadou, A. Kaur, J. Timms, N. Krishnan.
Renal Transplant, University Hospitals of Coventry and Warwickshire, Coventry, United Kingdom.
Introduction:It has been long established that over-immunosuppressed state leads to BK virus reactivation. BK viraemia (BKV) can progress to BK virus associated nephropathy (BKVAN) which…
2018 American Transplant Congress
Impact of De Novo DSA Development and Management on Kidney Transplant Outcomes
M. Cote,¹ M. Pavlakis,² F. Cardarelli,² J. Pena,³ A. Dinh,³ K. Richards,¹ K. Joyal,¹ C. Rogers.¹
¹Pharmacy, Beth Israel Deaconess Medical Center, Boston, MA; ²Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA; ³Pathology, Beth Israel Deaconess Medical Center, Boston, MA.
Multiple studies have shown that development of donor specific antibodies (DSAs) can have a negative impact on renal allograft outcomes resulting in decreased renal function,…
2018 American Transplant Congress
Effect of Belatacept on Late Acute Rejection Episodes and Graft Loss in Young Adults between the Ages of 18-24 Years: Post-Hoc Analysis of BENEFIT Study
A. Moudgil.
Nephrology, Children National Health System, Washington, DC.
Background: Recent data suggests higher incidence of late acute rejection (LAR) in young adults (18-24 years of age) causing graft loss just like adolescents due…