Date: Monday, June 4, 2018
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Kidney transplants (KT) from donors with acute kidney injury (AKI; terminal creatinine ≥ 2.0) are increasingly performed and have similar short-term outcomes compared with KT from donors without AKI. There are limited data on long-term outcomes of KT with AKI kidneys.
Methods: We reviewed all KT at our center from 2005-2009. Patients who received a KT from a donor with AKI were compared with KT recipients of kidneys with a terminal creatinine < 1.5. All patients received induction therapy and underwent early steroid withdrawal. Maintenance regimens were the same in the AKI and non-AKI groups (tacrolimus + MMF). We compared long-term renal function, patient and graft survival between the AKI and non-AKI groups. Patients were followed until death, graft failure, or 10/31/17.
Results: Recipient and transplant characteristics are shown in table.
|No AKI (n=374)||AKI (n=157)||p|
|Age||54 ± 13.1||52.8 ± 13.7||ns|
|Donor age||39.2 ± 21.3||39.2 ± 13.9||ns|
|Terminal creatinine||0.83 ± 0.33||3.16 ± 1.15||<0.01|
|Cold ischemia||30.7 ± 10.6||32.4 ± 9.8||ns|
|Creatinine 3-years||1.68 ± 1||1.62 ±0.74||ns|
|Creatinine 5-years||1.67 ± 0.9||1.71± 0.83||ns|
|Creatinine 7-years||1.49 ± 0.69||1.73 ± 0.9||p=0.02|
Conclusions: KT from donors with AKI provide similar excellent long-term patient and allograft survival compared with KT from donors without AKI. Long-term renal function, as measured by creatinine, was good in both groups, though AKI kidneys did have higher creatinine by 7 years. Increased use of AKI kidneys is a safe way to address the organ shortage.
CITATION INFORMATION: Dube G., Husain S., Cohen D., Mohan S. Excellent Long-Term Outcomes with Kidney Transplants from Deceased Donors with Acute Kidney Injury Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Dube G, Husain S, Cohen D, Mohan S. Excellent Long-Term Outcomes with Kidney Transplants from Deceased Donors with Acute Kidney Injury [abstract]. https://atcmeetingabstracts.com/abstract/excellent-long-term-outcomes-with-kidney-transplants-from-deceased-donors-with-acute-kidney-injury/. Accessed April 15, 2021.
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