Articles tagged "Graft survival"

2019 American Transplant Congress
Outcome of Renal Transplantation in Systemic Amyloidosis
S. Law¹, L. Helen², T. Resk², A. Wechalekar², J. Gillmore², R. Motallebzadeh¹
¹Renal Medicine, Royal Free Hospital, London, United Kingdom, ²UCL Division of Medicine, National Amyloidosis Centre, London, United Kingdom
*Purpose: Systemic amyloidosis accounts for approximately 0.8% of end stage renal disease (ESRD) in the UK. Outcomes following renal transplantation in systemic amyloidosis were historically…
2019 American Transplant Congress
Late Onset J C Virus Allograft Nephropathy
M. Samra, I. Tang, S. Setty
University of Illinois Health, Chicago, IL
*Purpose: JC virus(JCV) is a member of the Polyomaviridae family. Few studies have been published regarding the replication of JCV in transplant recipients. The incidence…
2019 American Transplant Congress
Inhibition of Th1 and Th17 Cell Differentiation and Prolonged Graft Survival through NFAT Pathway Downregulation
C. Dai¹, R. Tan¹, B. Yang¹, J. Markmann², D. Chen¹, L. Wei¹, Z. Chen¹
¹Institute of Organ Transplantation, Wuhan, China, ²Division of Transplantation, Boston, American Samoa
*Purpose: Extracts Aglaia (family Meliaceae) plants, specially Rocaglamide are used treatment strategy of autoimmune Inflammatory disease and allergic disease in traditional medicine in many Asia…
2019 American Transplant Congress
The Important Roles of Dendritic Cells in Transplantation
T. Ueno¹, M. M. McGrath¹, M. Y. Yeung¹, S. Cai¹, Y. Ueno¹, T. Yokoyama², Y. Kihara², O. Konno², Y. Nakamura², H. Iwamoto², A. K. Chandraker¹
¹Medicine, Renal Division, Brigham and Women's Hospital, Transplantation Research Center, Boston, MA, ²Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan
*Purpose: The interplay between dendritic cells (DCs) and T cells plays a central role in the process of allograft rejection. Upon antigen exposure, positive costimulatory…
2019 American Transplant Congress
External Validation of the Living Kidney Donor Profile Index (LKDPI) in the Canadian Kidney Transplant Recipient Population
M. Shantier¹, Y. Li¹, M. Ashwin¹, O. Famure¹, S. K. Singh²
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Department of Medicine, University of Toronto, Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: The LKDPI is a risk index which incorporates clinical characteristics of living kidney donors and their recipients to predict the risk of total graft…
2019 American Transplant Congress
Impact of Belatacept Conversion on Renal Function, Histology and Gene Expression in Kidney Transplant Patients with Interstitial Fibrosis and Tubular Atrophy
G. Gupta¹, D. Kumar¹, M. Raynaud², A. Loupy², J. Chang³, J. Reeve³, P. Sanghi¹, I. Yakubu¹, L. Kamal¹, M. Levy¹, C. Bhati¹, P. Kimball¹, A. King¹, H. Massey¹, P. Halloran³
¹Virginia Commonwealth University, Richmond, VA, ²Paris Transplant Group, Paris, France, ³Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Prior studies on the conversion of tacrolimus (Calcineurin Inhibitor; CNI) to belatacept have been limited in scope due to either the absence of, post-conversion…
2019 American Transplant Congress
Laminin α5 Deficiency in Lymph Node Stromal Cells Promotes Treg Migration and Allograft Survival
L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, T. Simon, N. Toney, C. Paluskievicz, J. S. Bromberg
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Laminins are a family of heterotrimeric glycoproteins, and lymph node (LN) stromal laminins α4 and α5 modulate suppression and immunity, respectively. We created laminin…
2019 American Transplant Congress
Change in Estimated Glomerular Filtration Rate and Risk of Allograft Failure in Patients Diagnosed with Active Antibody-Mediated Rejection Following Kidney Transplantation
W. Irish¹, P. Nickerson², B. Astor³, E. Chong⁴, C. Wiebe², F. Moreso⁵, D. Seron⁵, M. Crespo⁵, L. Gache⁶, A. Djamali³
¹East Carolina University, Greenville, NC, ²University of Manitoba, Winnipeg, MB, Canada, ³University of Wisconsin, Madison, WI, ⁴Vitaeris, Inc, Vancouver, BC, Canada, ⁵University Hospital Vall d'Hebron, Barcelona, Spain, ⁶CTI Clinical Trial & Consulting, Covington, KY
*Purpose: There are challenges in designing an adequate and well-controlled study of patients with active antibody-mediated rejection (ABMR), especially in the absence of a valid…
2019 American Transplant Congress
Urinary Extracellular Vesicles-Related Protein Biomarkers for the Non-Invasive Monitoring of Rejection in Kidney Transplanted Patients
L. Carreras-Planella¹, I. Bancu², D. Cucchiari³, L. Cañas², J. Juega², M. Franquesa¹, M. Perez-Mir², I. Revuelta³, F. Diekman⁴, R. Lauzurica², F. Borràs¹
¹REMAR-IVECAT Group, Institut Germans Trias i Pujol, Badalona, Spain, ²Nephrology- Renal Transplant Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ³Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Barcelona, Spain, ⁴Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Badalona, Spain
*Purpose: Chronic kidney rejection is currently the main cause of graft losses. Blood and urine analyses to monitor kidney transplanted patients are not specific, and…
2019 American Transplant Congress
Induction Therapy in Elderly Kidney Transplant Recipients with Low Immunological Risk
C. Masset¹, J. Boucquemont², V. Garrigue³, M. Ladrière⁴, F. Buron⁵, E. Cassuto⁶, Y. Foucher², J. Dantal¹
¹University Hospital of Nantes, Nantes, France, ²University of Nantes, Nantes, France, ³University Hospital of Montpellier, Montpellier, France, ⁴University Hospital of Nancy, Nancy, France, ⁵University Hospital of Lyon, Lyon, France, ⁶University Hospital of Nice, Nice, France
*Purpose: Thymoglobulin (ATG) and Basiliximab (BSX) lead to similar rejection rates in low immunological risk patients. ATG seems to be associated with infectious and malignancy…