Articles tagged "Graft survival"

2015 American Transplant Congress
Outcomes of Treatment of Late Antibody-Mediated Rejection in Primary Renal Transplant Recipients – A Single Center Experience
R. Prashar, A. Patel, K. Venkat.
Division of Nephrology and Transplant Institute, Henry Ford Hospital, Detroit, MI.
Background: Successful reversal of early post-transplant antibody mediated rejection (AMR) is well documented, but data on the results of treatment of late AMR are lacking.…
2015 American Transplant Congress
Transplantation of Kidneys from Donors With Acute Renal Failure: Five-Year Results from Double Center Experience
C. Ramirez,^1,2 A. Safra,¹ A. Shah,^1,2 C. Doria,¹ W. Maley,¹ A. Frank,¹ C. Gorn,¹ L. Lerner.²
¹Department of Surgery, Division of Transplantation, Thomas Jefferson University Hospital, Philadelphia, PA; ²Department of Kidney Transplantation, Lankenau Medical Center, Wynnewood, PA.
Background: Transplantation of kidneys from deceased donors with acute renal failure (ARF) has been described and represents an underutilized source of renal grafts. We reviewed…
2015 American Transplant Congress
High Intra-Patient Variability in Tacrolimus Trough Blood Levels Increases the Risk of Death-Censored Graft Loss After Kidney Transplantation
E. Rodrigo,¹ D. San Segundo,² J. Ruiz,¹ M. López-Hoyos,² A. Benito,¹ M. de Cos,³ Z. Albines,¹ M. Serrano,¹ M. Arias.¹
¹Nephrology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; ²Immunology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; ³Pharmacology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain.
Kidney graft loss rates beyond the first year showed only small improvements over past decades. Advances in maintenance immunosuppressive therapy contributed to the improvements seen…
2015 American Transplant Congress
The Impact of Donor Alcohol Intake on Pancreatic Graft Survival
R. Motallebzadeh,¹ M. Drage,² J. Olsburgh,² C. Callaghan.²
¹Surgery, Cambridge University Hospital, Cambridge, United Kingdom; ²Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Introduction:Alcohol (EtOH) abuse can damage the pancreas, but outcomes of pancreas transplantation from donors with a high EtOH intake are poorly defined. The aim of…
2015 American Transplant Congress
Early Steroid Withdrawal and Calcineurin Inhibitor Minimization Protocols for Maintenance Immunosuppression: A Single Center 10-Year Experience
R. Lopez-Soler,¹ L. Park,³ J. Martinolich,² D. Conti.¹
¹Transplant Surgery, Albany Medical Center, Albany, NY; ²Surgery, Albany Medical Center, Albany, NY; ³Albany School of Medicine, Albany, NY.
BACKGROUND:Long term use of steroids results in predictable secondary effects that can lead to increased morbidity and mortality. Additionally, long term high levels of Calcineurin…
2015 American Transplant Congress
Transplanting Pediatric Livers Into Adult Recipients Is Associated With Increased Rejection and Decreased Survival
V. Fleetwood, J. Harris, M. Hertl, E. Chan.
General Surgery, Division of Transplantation, Rush University Medical Center, Chicago, IL.
Introduction: Transplantation of pediatric livers to adult recipients, a measure which places the graft at higher risk of hepatic artery thrombosis (HA), is frequently necessitated…
2015 American Transplant Congress
Impact of Cold Ischemic Time (CIT) and Distance Traveled (DT) on Shipped Kidneys in the OPTN/UNOS Kidney Paired Donation (KPD) Pilot Program (PP)
M. Aeder,¹ D. Stewart,² R. Leishman,² L. Robbins Callahan,² A. Kucheryavaya,² T. Sandholm,³ R. Formica.⁴
¹Univ Hosp Case Med Ctr, Cleveland, OH; ²UNOS, Richmond, VA; ³Carnegie Mellon Univ, Pittsburgh, PA; ⁴Yale Univ, New Haven, CT.
Background: The success of a national KPD program is predicated on excellent early kidney function and graft survival (GS). As other KPD programs have reported…
2015 American Transplant Congress
Effects of Toll Like Receptor (TLR) Signaling on Murine Alloimmunity Are Modulated by Immune Cell Derived Complement
J. Sheen, P. Heeger.
Translational Transplant Research Center, Department of Medicine and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
TLR signals prevent CD40L-blockade (MR1) induced murine transplant tolerance but mechanisms are incompletely understood. Based on previous findings that immune cell derived complement activation products…
2015 American Transplant Congress
Impact of Pre-Transplant Panel Reactive Antibody Levels On Renal Graft Survival in Patients With Negative Cross-Match and No Donor Specific Antibody
K. Jun,¹ M. Kim,¹ H. Kim,¹ K. Park,² S. Ahn,¹ J. Hwang,¹ S. Kim,¹ S. Park,¹ S. Kim,¹ J. Kim,¹ I. Moon.¹
¹Vascular and Transplant Surgery, The Catholic University of Korea, Seoul, Korea; ²Vascular Surgery, Inha University, Incheon, Korea.
Purposes: This study was conducted to investigate the impact of pre-transplant PRA level on rejection and graft survival after kidney transplantation in patients with negative…
2015 American Transplant Congress
Six-Month Urinary CCL2 Levels Predict Long-Term Renal Allograft Outcome
J. Ho,¹ D. Rush,¹ A. Gao,¹ H. Hopfer,² C. Wiebe,¹ P. Nickerson,¹ S. Schaub,² P. Hirt-Minkowski.²
¹Internal Medicine, Nephrology, University of Manitoba, Winnipeg, MB, Canada; ²Transplantation Immunology & Nephrology, University Hospital, Basel, Basel, Switzerland.
Graft loss is a major cause of morbidity and mortality. We have shown that 6-month urine CCL2 is an independent predictor for death-censored graft loss.…