Articles tagged "Graft survival"

2015 American Transplant Congress
Transplantation of Kidneys from Donors With Acute Renal Failure: Five-Year Results from Double Center Experience
C. Ramirez,^1,2 A. Safra,¹ A. Shah,^1,2 C. Doria,¹ W. Maley,¹ A. Frank,¹ C. Gorn,¹ L. Lerner.²
¹Department of Surgery, Division of Transplantation, Thomas Jefferson University Hospital, Philadelphia, PA; ²Department of Kidney Transplantation, Lankenau Medical Center, Wynnewood, PA.
Background: Transplantation of kidneys from deceased donors with acute renal failure (ARF) has been described and represents an underutilized source of renal grafts. We reviewed…
2015 American Transplant Congress
High Intra-Patient Variability in Tacrolimus Trough Blood Levels Increases the Risk of Death-Censored Graft Loss After Kidney Transplantation
E. Rodrigo,¹ D. San Segundo,² J. Ruiz,¹ M. López-Hoyos,² A. Benito,¹ M. de Cos,³ Z. Albines,¹ M. Serrano,¹ M. Arias.¹
¹Nephrology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; ²Immunology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; ³Pharmacology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain.
Kidney graft loss rates beyond the first year showed only small improvements over past decades. Advances in maintenance immunosuppressive therapy contributed to the improvements seen…
2015 American Transplant Congress
The Impact of Donor Alcohol Intake on Pancreatic Graft Survival
R. Motallebzadeh,¹ M. Drage,² J. Olsburgh,² C. Callaghan.²
¹Surgery, Cambridge University Hospital, Cambridge, United Kingdom; ²Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Introduction:Alcohol (EtOH) abuse can damage the pancreas, but outcomes of pancreas transplantation from donors with a high EtOH intake are poorly defined. The aim of…
2015 American Transplant Congress
Early Steroid Withdrawal and Calcineurin Inhibitor Minimization Protocols for Maintenance Immunosuppression: A Single Center 10-Year Experience
R. Lopez-Soler,¹ L. Park,³ J. Martinolich,² D. Conti.¹
¹Transplant Surgery, Albany Medical Center, Albany, NY; ²Surgery, Albany Medical Center, Albany, NY; ³Albany School of Medicine, Albany, NY.
BACKGROUND:Long term use of steroids results in predictable secondary effects that can lead to increased morbidity and mortality. Additionally, long term high levels of Calcineurin…
2015 American Transplant Congress
Part II: Rates and Determinants of Progression for De Novo Donor-Specific Antibody Mediated Kidney Allograft Injury
C. Wiebe,^1,2 I. Gibson,³ D. Pochinco,² P. Birk,⁴ T. Blydt-Hansen,⁴ J. Ho,^1,5 M. Karpinski,¹ A. Goldberg,⁴ L. Storsley,¹ D. Rush,¹ P. Nickerson.^1,2,5
¹Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Immunogenetics, Diagnostic Services of Manitoba, Winnipeg, MB, Canada; ³Pathology, University of Manitoba, Winnipeg, MB, Canada; ⁴Pediatric and Child Health, University of Manitoba, Winnipeg, MB, Canada; ⁵Immunology, University of Manitoba, Winnipeg, MB, Canada.
The development of de novo donor-specific antibody (dnDSA) is an independent predictor of allograft loss in renal transplantation. Rates and determinants of clinical pathologic progression…
2015 American Transplant Congress
Impact of Cold Ischemic Time (CIT) and Distance Traveled (DT) on Shipped Kidneys in the OPTN/UNOS Kidney Paired Donation (KPD) Pilot Program (PP)
M. Aeder,¹ D. Stewart,² R. Leishman,² L. Robbins Callahan,² A. Kucheryavaya,² T. Sandholm,³ R. Formica.⁴
¹Univ Hosp Case Med Ctr, Cleveland, OH; ²UNOS, Richmond, VA; ³Carnegie Mellon Univ, Pittsburgh, PA; ⁴Yale Univ, New Haven, CT.
Background: The success of a national KPD program is predicated on excellent early kidney function and graft survival (GS). As other KPD programs have reported…
2015 American Transplant Congress
Effects of Toll Like Receptor (TLR) Signaling on Murine Alloimmunity Are Modulated by Immune Cell Derived Complement
J. Sheen, P. Heeger.
Translational Transplant Research Center, Department of Medicine and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
TLR signals prevent CD40L-blockade (MR1) induced murine transplant tolerance but mechanisms are incompletely understood. Based on previous findings that immune cell derived complement activation products…
2015 American Transplant Congress
Impact of Pre-Transplant Panel Reactive Antibody Levels On Renal Graft Survival in Patients With Negative Cross-Match and No Donor Specific Antibody
K. Jun,¹ M. Kim,¹ H. Kim,¹ K. Park,² S. Ahn,¹ J. Hwang,¹ S. Kim,¹ S. Park,¹ S. Kim,¹ J. Kim,¹ I. Moon.¹
¹Vascular and Transplant Surgery, The Catholic University of Korea, Seoul, Korea; ²Vascular Surgery, Inha University, Incheon, Korea.
Purposes: This study was conducted to investigate the impact of pre-transplant PRA level on rejection and graft survival after kidney transplantation in patients with negative…
2015 American Transplant Congress
Six-Month Urinary CCL2 Levels Predict Long-Term Renal Allograft Outcome
J. Ho,¹ D. Rush,¹ A. Gao,¹ H. Hopfer,² C. Wiebe,¹ P. Nickerson,¹ S. Schaub,² P. Hirt-Minkowski.²
¹Internal Medicine, Nephrology, University of Manitoba, Winnipeg, MB, Canada; ²Transplantation Immunology & Nephrology, University Hospital, Basel, Basel, Switzerland.
Graft loss is a major cause of morbidity and mortality. We have shown that 6-month urine CCL2 is an independent predictor for death-censored graft loss.…
2015 American Transplant Congress
Recreational Marijuana Use Is Not Associated With Worse Kidney Allograft Outcomes
G. Greenan, M. Anders, A. Leeser, J. Bromberg, S. Niederhaus.
Department of Surgery, University of Maryland, Baltimore, MD; Department of Anesthesiology, University of Maryland, Baltimore, MD; Department of Surgery, University of Maryland, Baltimore, MD; Department of Surgery, University of Maryland, Baltimore, MD; Department of Surgery, University of Maryland, Baltimore, MD.
Background: As marijuana (MJ) legalization is ongoing, kidney transplant programs need to develop listing criteria for MJ users. No data exist on whether recreational MJ…