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The Impact of Donor Alcohol Intake on Pancreatic Graft Survival

R. Motallebzadeh,1 M. Drage,2 J. Olsburgh,2 C. Callaghan.2

1Surgery, Cambridge University Hospital, Cambridge, United Kingdom
2Transplantation, Guy's and St Thomas'
NHS Foundation Trust, London, United Kingdom.

Meeting: 2015 American Transplant Congress

Abstract number: C205

Keywords: Alcohol, Graft survival, Pancreas

Session Information

Date: Monday, May 4, 2015

Session Name: Poster Session C: More Controversies in Pancreas Transplantation

Session Time: 5:30pm-6:30pm

 Presentation Time: 5:30pm-6:30pm

Location: Exhibit Hall E

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Introduction:

Alcohol (EtOH) abuse can damage the pancreas, but outcomes of pancreas transplantation from donors with a high EtOH intake are poorly defined. The aim of this study was to determine if donor EtOH intake influenced pancreas allograft survival in SPK transplantation.

Methods: UK registry data was used to assess graft survival in SPK recipients between 2006-2012. Core donor data forms were analysed and (where quantified) EtOH intake was calculated. Variables were stratified by donor EtOH intake: group I – quantified high recent EtOH intake (>21 units/week in males; >14 units/week in females) or a history of EtOH abuse; group II – no (or unknown) history of EtOH abuse and a recent intake less than the above thresholds. Continuous variables are expressed as median (IQR).

Results: Seven hundred and seventy SPK transplants were performed (group I, n=120; group II, n=650). In group I, 51 donors had high quantified recent EtOH intake only, 34 had a history of EtOH abuse but recent intake wasn't documented, 33 had a history of abuse with a high recent intake documented, and 2 had a history of abuse with a recent intake less than threshold. As expected, quantified current EtOH intake was higher in group I than group II (39 (24-59) vs 10 (5-13) units/week; p<0.001). Donors in group I were more likely to be male (61% vs 49%; p=0.02), and older (42 (32-48) vs 38 (26-46) years; p<0.001); however, there were no differences in the proportions of DCD donors, median donor BMI, or median recipient age between the two groups. Cold ischaemic time was shorter in group I (660 (539-839) vs 733 (613-900) mins; p<0.001). There was no difference in subsequent graft survival between groups I and II (5yr graft survival 74% v 76% respectively, p=0.95, log rank test), or between group II and the sub-group of 33 donors with both a history of EtOH abuse and a high recent intake (5yr graft survival 76% vs 57% respectively, p=0.17, log rank test).

Conclusions: Pancreas donors with past EtOH abuse or recent high intake are common, and graft outcomes appear to be as good as those who have received a pancreas from donors with normal EtOH intake/no history of EtOH abuse. This analysis suggests that excessive donor EtOH intake, by itself, should not exclude pancreas utilisation.

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To cite this abstract in AMA style:

Motallebzadeh R, Drage M, Olsburgh J, Callaghan C. The Impact of Donor Alcohol Intake on Pancreatic Graft Survival [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/the-impact-of-donor-alcohol-intake-on-pancreatic-graft-survival/. Accessed January 27, 2021.

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